Navigation Links
Animal models that help translate regenerative therapies from bench to bedside
Date:2/11/2010

New Rochelle, NY, February 11, 2010Clinical testing and development of novel therapies based on advances in tissue engineering and regenerative medicine that will one day enable the repair and replacement of diseased or damaged human muscle, bone, tendons, and ligaments depends on the availability of good animal models. The highlights of a recent workshop that explored the need for and current status of animal models for musculoskeletal regenerative medicine are presented in a special issue of Tissue Engineering, Part B: Reviews, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) The issue is available free online (www.liebertpub.com/ten).

The production of specially engineered tissues to restore the function and viability of cartilage or meniscus in the knee, for example, or of degenerating intervertebral discs in the spine, will likely one day be commonplace. In the meantime, however, there is substantial need for better and standardized animal models for the development and testing of these innovative techniques. At the National Institutes of Health (NIH)-sponsored workshop "Translational Models for Musculoskeletal Tissue Engineering and Regenerative Medicine," leaders in the field described available models, outlined the unmet needs, and discussed the translational pathways for clinical testing and therapeutic use.

Mark Lee, PhD, and colleagues from the U.S. Food and Drug Administration (FDA, Rockville, MD) explained how the complexity of engineered tissue constructs, often containing a combination of cells, scaffolds, and other factors, creates challenges for product characterization and manufacturing. In their paper "Considerations for Tissue-Engineered and Regenerative Medicine Product Development Prior to Clinical Trials in the United States," they provide resources and recommendations to help product developers optimize the safety and effectiveness of engineered tissues ready for testing in clinical trials.

Focusing on the challenges of applying regenerative medicine technologies to the surgical repair of torn rotator cuffs, Kathleen Derwin, PhD, and coworkers from the Cleveland Clinic in Ohio identified appropriate animal models for research, development, and testing of repair strategies. In their paper, "Preclinical Models for Translating Regenerative Medicine Therapies for Rotator Cuff Repair," they emphasize the need for discriminating preclinical models in which researchers can experiment with the materials and procedures that will ultimately be used to treat human patients.

Damage and degeneration of cartilage is a leading cause of pain and disability associated with the development of osteoarthritis. In their review article "Animal Models for Cartilage Regeneration and Repair," Michal Szczodry, MD, Stephen Bruno, and Constance Chu, MD, from the University of Pittsburgh (Pennsylvania), emphasize the value of animal studies to understand the disease process underlying joint degeneration and to develop effective treatments for cartilage injuries.

"The workshop and manuscripts they produced provide an excellent summary of the tools we have available to translate new technologies forward, toward clinical studies. They also identify the critical gaps in our current knowledge," says Anthony Ratcliffe, PhD, President and CEO of Synthasome, Inc., and a guest editor of this special issue.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2156
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert

Related biology news :

1. Animals cope with climate change at the dinner table
2. New on-off switch triggers and reverses paralysis in animals with a beam of light
3. NIFA awards funding for animal health and production research
4. Better food makes high-latitude animals bigger
5. Oral COTI-2 is effective in a second animal model of human pancreatic cancer
6. Animal behavioral studies can mimic human behavior
7. Roe of marine animals is best natural source of omega-3
8. ORAL COTI-2 IS EFFECTIVE IN AN ANIMAL MODEL OF HUMAN PANCREATIC CANCER
9. New on-off switch triggers and reverses paralysis in animals with a beam of light
10. Master regulator found for regenerating nerve fibers in live animals
11. Geologist analyzes earliest shell-covered fossil animals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by ... Global Forecast to 2022", published by MarketsandMarkets, the market is expected to be ... 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... Yorba Linda, Ca (PRWEB) , ... March 28, 2017 , ... ... in various settings. The utilization of this technology is driven by its potential to ... powerful tool, there are also some challenges that must be addressed for it to ...
(Date:3/28/2017)... Michigan (PRWEB) , ... March 28, 2017 , ... ... awarded a Phase II Small Business Innovation Research (SBIR) grant from the National ... approximately $750,000 over two years to develop a suite of BioGelâ„¢ biopolymer materials ...
(Date:3/28/2017)... WASHINGTON , March 28, 2017  (AACR17, Booth ... sequencing during the American Association for Cancer Research (AACR) ... in Washington, D.C. , April 1-5, ... expression of thousands of cells at the individual level. ... Experts on-hand at AACR to discuss expanded next ...
(Date:3/28/2017)... 2017  Viking Therapeutics, Inc. ("Viking") (NASDAQ: VKTX), a ... therapies for metabolic and endocrine disorders, today announced that ... will deliver a corporate presentation at H.C. Wainwright & ... held April 3, 2017 at the St. Regis Hotel ... presentation are as follows: H.C. ...
Breaking Biology Technology: