Navigation Links
Animal food allergens unmasked
Date:10/14/2007

The relatedness of an animal food protein to a human protein determines whether it can cause allergy, according to new research by scientists from the Institute of Food Research in Norwich and the Medical University of Vienna.

In theory all proteins have the potential to become allergens, but the study found that in practice the ability of animal food proteins to act as allergens depends on their evolutionary distance from a human equivalent.

This explains why people who are allergic to cows milk can often tolerate mares milk but not goats milk, said Dr Clare Mills of the Institute of Food Research. Proteins in horse milk are up to 66% identical to human milk proteins, while known allergens from cows and goats are all less than 53% identical to corresponding human proteins.

Overall we found that only an animal food protein that is less than 54% identical to a human equivalent could become allergenic.

Cows milk and hens eggs are common causes of allergy in infants, while the most common animal food allergens in adults are fish and seafood.

For the first time the researchers found that the majority of animal food allergens could be classified into one of three protein families. Tropomyosins, proteins found in muscle tissue, are the most important family.

Tropomyosins in mammals, fish and birds are at least 90% identical to at least one human tropomyosin and none have been reported to be allergenic. In contrast, the allergenic tropomyosins are all from invertebrates such as insects, crustaceans and nematodes and at most are only 55% identical to the closest human homologue, said Dr Heimo Breiteneder of the Medical University of Vienna.

EF-hand proteins form the second largest animal food allergen family. Those in birds and mammals are not allergenic, while those in frogs and fish can cause allergy. The third animal food allergen family, caseins, are all mammalian proteins from milk. The researchers analysed milk from rabbits, rats and camels as well as sheep, goats, cows and horses.

In previous analyses of plant food allergens published in 2005, the scientists found that most belong to a highly restricted number of protein superfamilies. The research will make it easier to identify new allergens and help explain how they trigger an immune response.

Animal food proteins lie at the limits of the capability of the human immune system to discriminate between foreign and self proteins, said Dr Mills. Immune responses to some animal food allergens such as the invertebrate tropomyosins, run close to becoming a form of autoimmune response and this needs to be considered when developing allergy therapies.


'/>"/>

Contact: Zoe Dunford
zoe.dunford@bbsrc.ac.uk
44-016-032-55111
Norwich BioScience Institutes
Source:Eurekalert

Related biology news :

1. Plants, animals share molecular growth mechanisms
2. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
3. Study Links Ebola Outbreaks To Animal Carcasses
4. Scientists rid stem cell culture of key animal cells
5. Elephants imitate truck noises, other animals
6. UCSD researchers maintain stem cells without contaminated animal feeder layers
7. Gene Therapy For Parkinsons Disease Moves Forward In Animals
8. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
9. Gene therapy for Parkinsons disease moves forward in animals
10. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
11. Flocking together: Study shows how animal groups find their way
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
(Date:2/9/2017)... Feb. 9, 2017 The biomass boiler market ... the biomass boiler market globally in terms of revenue ... boilers. The market for biomass boilers has been segmented ... application, and country/region. The market based on feedstock type, ... residues, biogas & energy crops, urban residues, and others. ...
(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... The global ... reach $11.4 billion by 2021, growing at a compound annual ... - An overview of the global markets for synthetic biology. ... estimates for 2016, and projections of compound annual growth rates ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... ... February 28, 2017 , ... ... of antibody therapeutics from millions-diverse immune repertoires, today announced a strategic partnership with ... strains genetically engineered to express human antibodies. The partnership will use GigaGen technology ...
(Date:2/28/2017)... , Feb. 28, 2017  ITL Limited ... company, supplier and strategic partner that provides innovative ... individual health management, formally announces its rebrand to ... name change is part of the Company,s unified ... launch of an integrated corporate website, ITLHealthGroup.com ...
(Date:2/28/2017)... and NEW YORK , February ... License Application accepted by the FDA for avelumab  ... disease has metastasized   ... Germany , in the US and ... US Food and Drug Administration (FDA) has accepted for Priority ...
(Date:2/27/2017)... -- A Europe-wide survey of institutes conducted by the ... their research treat them with due care. The survey polled a ... the results indicates that there is a strong commitment among animal ... the principles of the 3Rs (Refine, Reduce, Replace)  ... What are the 3Rs? ...
Breaking Biology Technology: