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Animal cells can communicate by reaching out and touching, UCSF team discovers
Date:1/2/2014

gnaling. A cell that takes up insulin does not care where that insulin came from a pancreas or an intravenous injection. But there are signals of a specialized type, such as those that pass between stem cells and the cells around them, or signals that determine tissue growth, patterning and function, where the identity of the communicating cells must be precisely defined. It's important that these signals are received in the context of the cells that are making them."

Kornberg noted that other research teams have made observations that suggest that cytoneme-based signaling may also occur "between stem cells and the cells that instruct them on what they are going to do and where they are going to go." Cancer cells may also use this method to communicate with their neighbors, he said.

The discovery of animal cell cytonemes and the critical role they play in long distance signaling "opens up a wonderful biology of which we have very little understanding at this point," said Kornberg. "For example, how do these cytonemes find their targets? How do they know when they have found them? These are some of the questions that we are pursuing."


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Contact: Peter Farley
peter.farley@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert

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