Navigation Links
Anglo-French team discover elusive gene that makes platelets gray
Date:7/25/2011

omboGenomics initiative.

The scientists observed that other members from the same family of BEACH proteins are implicated in other rare inherited disorders. Their findings showed that LYST protein did not function well in Chediak-Higashi syndrome, another rare but severe disorder paralysing the immune system but also causing a mild platelet bleeding disorder. As a result, a picture is emerging that BEACH proteins are essential in the way granules in blood cells and brain cells are formed or retained showing that in platelets the BEACH proteins are essential for both alpha and dense granules.

"Our discovery that another member of the family of BEACH proteins is underlying a rare but severe granule disorder in platelets firmly nails down the important role of this class of proteins in granule biology," said Cornelis Albers, a British Heart Foundation research fellow at the Sanger Institute and the University of Cambridge. "The reasons why the platelets of patients with Gray Platelet Syndrome are gray is because they lack alpha granules. The alpha granules carry the cargo of proteins that induce vessel wall repair and also form the platelet plug.

"A better understanding of how these granules are formed and how their timely release by the platelet is coordinated at the molecular level may one day underpin the development of a new class of safer anti-platelet drugs for use in patients with heart attacks and stroke. It has been a fascinating journey to identify a new and important pathway by combining the rapid advances in sequencing technology with computational analysis."

The French collaboration was led by Dr Paquita Nurden who set up the Network for Rare Platelet Disorders at the Laboratoire d'Hmatologie, Hopital Xavier Arnozan close to Bordeaux. Their team made the Heruclian effort to find the French families affected by this rare disorder.

"We have worked for years to identify the families across France that suffer
'/>"/>

Contact: Don Powell
press.office@sanger.ac.uk
Wellcome Trust Sanger Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Formula discovered for longer plant life
2. Chemical equator discovery will aid pollution mapping
3. Researchers discover that growing up too fast may mean dying young in honey bees
4. Scientists discover why a mothers high-fat diet contributes to obesity in her children
5. Sirtris review of sirtuin therapeutics for diseases of aging in Nature Reviews Drug Discovery
6. Groundbreaking discovery may lead to stronger antibiotics
7. Discovery of natural compounds that could slow blood vessel growth
8. Earliest animal footprints ever found -- discovered in Nevada
9. Nanoscopic screening process to speed drug discovery
10. Discovering drugs, biofuels in tropical seas
11. Important new hair-loss gene discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... Alliance and the EMV Migration Forum.  ... Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. direct ... promoting adoption of smart card technology. To ...
(Date:8/17/2015)... 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... for Q4 2015. The new marketing campaign is being ... Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( ... leader in retail driven marketing and brand awareness and ...
(Date:8/12/2015)... JOSE, Calif. , Aug. 12, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... recently announced Match-in-Sensor solution, have officially been named ... Alliance. As part of the certification, Synaptics, Natural ... FIDO 1.0 Universal Authentication Framework (UAF) standard and ...
Breaking Biology News(10 mins):NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... new studies may lead to the development of more effective ... incurable blood cell cancer. The research, published by Cell Press ... new insight into the molecular mechanisms that underlie aberrant NF-κB ... the NF-κB signaling pathway as a target for MM therapy. ...
... use their ultrasonic echolocation calls to recognise their own ... by Danilo Russo and colleagues suggests that this is ... find their way in the dark and detect insect ... a constant frequency. Different rhinolophid species show different frequency ...
... the latest American Chemical Society (ACS) News Service Weekly PressPac ... Engineering News. ,Please credit the individual journal or the American ... ,ACS NEWS SERVICE Aug. 8, 2007,Weekly PressPac ... is embargoed for 9 A. M., Eastern Time, August 15, ...
Cached Biology News:Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma 2A 'private bandwidth' for communication in bats: Evidence from insular horseshoe bats 2American Chemical Society's Weekly PressPac -- Aug. 8, 2007 2American Chemical Society's Weekly PressPac -- Aug. 8, 2007 3American Chemical Society's Weekly PressPac -- Aug. 8, 2007 4American Chemical Society's Weekly PressPac -- Aug. 8, 2007 5American Chemical Society's Weekly PressPac -- Aug. 8, 2007 6American Chemical Society's Weekly PressPac -- Aug. 8, 2007 7American Chemical Society's Weekly PressPac -- Aug. 8, 2007 8American Chemical Society's Weekly PressPac -- Aug. 8, 2007 9
(Date:8/31/2015)... ON , Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. ... orders totalling $5.7 million. The orders are for air emission abatement ... "Of particular note is a large order for a municipality ... equipment will be replacing a competitor,s system that failed to ... in our engineered solutions," said Derek S. Webb , ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and Markets ... "Argentina Biomedical Sensors Market - Growth, Trends & ... The Argentina Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Middle East & Africa Biomedical Sensors Market - Growth, ... The Middle East ... $0.84 billion by 2018 at a CAGR of 3.26% ... will bring Biomedical sensors that are adaptable to the ...
(Date:8/31/2015)... 31, 2015  RXi Pharmaceuticals Corporation (NASDAQ: ... and developing innovative therapies primarily in the areas ... 30-day review period following the filing of the ... with the U.S. Food and Drug Administration (FDA) ... Logo -  http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
Breaking Biology Technology:Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4
... June 15, 2011 PharmAthene, Inc. (NYSE Amex: ... against biological and chemical threats, announced today that it ... gross proceeds for the Company of approximately $6.5 million. ... PharmAthene sold an aggregate of 1,857,143 units to certain ...
... JOLLA, Calif., June 15, 2011 Synthetic Genomics, Inc. ... to a variety of global needs including clean renewable ... Joseph Mahler will join the company as Chief Financial ... responsible for leading and directing all financial aspect of ...
... June 15, 2011 NeoStem, Inc. ("NeoStem" or the ... biopharmaceutical company with product and service revenues, global research ... units – U.S. adult stem cells, China adult stem ... Vice President of Strategic Business Development, will present at ...
Cached Biology Technology:PharmAthene Completes $6.5 Million Registered Direct Offering 2PharmAthene Completes $6.5 Million Registered Direct Offering 3Synthetic Genomics Inc. Appoints Joseph Mahler as Chief Financial Officer 2NeoStem to Present at Two Investor Events This Month 2NeoStem to Present at Two Investor Events This Month 3NeoStem to Present at Two Investor Events This Month 4
...
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
Jak3 Antibody Ship: Hot Store: -20 C...
B3GALT2 Immunogen: B3GALT2 (NP_003774, 324 a.a. ~ 423 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: