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Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition
Date:3/24/2010

The linkage between the repetitive use of isoflurane anesthesia and the development of AD changes in mice with mutations indicates the advisability of testing for genetic risk factors for AD in patients prior to surgery. Until recently, the most important genetic risk factor for AD was the presence of the allele E4 of the apolipoprotein E, but recently other genetic polymorphisms of risks have been identified. Once these polymorphisms of risks are identified and their relative impact on the pathogenesis of AD are known, a simple, automatic test for risk of AD should be performed in patients, namely the elderly, undergoing surgery under general anesthesia and the anesthetic procedure should be modified accordingly. A personalized clinical model that would enable the reduction of the patient's potential risk for AD would reduce the risk of anesthesia.

Study conclusions:

The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice", confirms that anesthesia is safe for normal mice but risky for asymptomatic carriers of mutations wich produce AD.

The research has been based on the application of anesthesia twice a week during three months in normal mice and in mice with mutations (7-10 months old) that produce AD (known as APPswe ). The results show alterations produced in the brain of mice with mutations very similar to those observed in patients that have already developed Alzheimer's disease.

Study highlights:

  • Application of repetitive anesthesia in genetically altered mice increased their death rate.
  • Mutant mice showed less reactivity after anesthesia was over. Their time for recovery after anesthesia was also increased.
  • Repetitive anesthesia produced persistent disorders affecting behavior of mutant mice.
  • Neuronal death increased in brain areas critical for cognition.
  • Increased inflammatory response and deposit
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Contact: Raquel Lumbreras
Raquel_lumbreras@duomocomunicacion.com
34-913-119-289
IOS Press
Source:Eurekalert

Page: 1 2 3

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