Navigation Links
Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition
Date:3/24/2010

The linkage between the repetitive use of isoflurane anesthesia and the development of AD changes in mice with mutations indicates the advisability of testing for genetic risk factors for AD in patients prior to surgery. Until recently, the most important genetic risk factor for AD was the presence of the allele E4 of the apolipoprotein E, but recently other genetic polymorphisms of risks have been identified. Once these polymorphisms of risks are identified and their relative impact on the pathogenesis of AD are known, a simple, automatic test for risk of AD should be performed in patients, namely the elderly, undergoing surgery under general anesthesia and the anesthetic procedure should be modified accordingly. A personalized clinical model that would enable the reduction of the patient's potential risk for AD would reduce the risk of anesthesia.

Study conclusions:

The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice", confirms that anesthesia is safe for normal mice but risky for asymptomatic carriers of mutations wich produce AD.

The research has been based on the application of anesthesia twice a week during three months in normal mice and in mice with mutations (7-10 months old) that produce AD (known as APPswe ). The results show alterations produced in the brain of mice with mutations very similar to those observed in patients that have already developed Alzheimer's disease.

Study highlights:

  • Application of repetitive anesthesia in genetically altered mice increased their death rate.
  • Mutant mice showed less reactivity after anesthesia was over. Their time for recovery after anesthesia was also increased.
  • Repetitive anesthesia produced persistent disorders affecting behavior of mutant mice.
  • Neuronal death increased in brain areas critical for cognition.
  • Increased inflammatory response and deposit
    '/>"/>

Contact: Raquel Lumbreras
Raquel_lumbreras@duomocomunicacion.com
34-913-119-289
IOS Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Anesthesia and Alzheimers
2. Study finds Viagra increases release of key reproductive hormone
3. Springer increases publishing activities in South Korea
4. Age increases chance of success as two-timer
5. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
6. Waterborne carbon increases threat of environmental mercury
7. New study increases concerns about climate model reliability
8. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
9. Washington University increases fleet of Roche Genome Sequencer FLX Systems
10. Gene variant increases breast cancer risk
11. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... disease (CVD) claims 17 million lives each year, while ... million. 1 New research presented by international scientists ... France on September 15, 2014, suggests that milk consumption ... At the Milk and Dairy Products in Human ... for hypertension and CVD was examined by Dr. Sabita ...
(Date:9/15/2014)... need for vitamin E and how much is enough, ... of this essential micronutrient are especially critical for the ... may become pregnant. , A lifelong proper intake of ... complicated by the fact that this nutrient is one ... It has been estimated that only a tiny fraction ...
(Date:9/12/2014)... , September 12, 2014 ... ( http://www.researchandmarkets.com/research/trs4c7/global ) has announced the addition ... Report 2014" report to their offering. ... Industry Report 2014 is a professional and ... the global fingerprint lock industry. , ,The ...
Breaking Biology News(10 mins):Dairy consumption linked to lower blood pressure and cardiovascular disease risk 2Vitamin E intake critical during 'the first 1,000 days' 2Vitamin E intake critical during 'the first 1,000 days' 3Global Fingerprint Lock Industry Report 2014 2
... compound found in cocoa, are so striking that it may ... health, reports Marina Murphy in Chemistry & Industry, the magazine ... Medical School, told C&I that epicatechin is so important that ... spent years studying the benefits of cocoa drinking on the ...
... joint funding from the Engineering and Physical Science Research ... develop an innovative sensor to detect bacteria. The new ... fluorescent signal when it encounters bacteria, allowing scientists to ... methodologies. , The new technology will be ...
... childbearing age struggle with the heartache of infertility. Now there ... of a mutation in a gene that causes male infertility ... dominant mutation that leads specifically to infertility in a mammal ... for similar mutations in the DNA of infertile men. , ...
Cached Biology News:Cocoa 'vitamin' health benefits could outshine penicillin 2Researchers find gene mutation that causes infertility in male mice 2
(Date:9/16/2014)... 2014 According to Jeff Howell, Partner ... ITRA Global, new development in Downtown Toronto is expanding ... approving another 755 storeys of new development last week ... will be dominating the Toronto skyline for the foreseeable ... unquenchable thirst for new development. , As the Toronto ...
(Date:9/16/2014)... September 16, 2014 RENU 28, the world's ... became available for purchase in Australia and New Zealand ... tour beginning September 16th. The tour will make stops in ... Bundaberg on the 18th, Sydney on the 20th, and Melbourne ... Australia and New Zealand and to educate people about the ...
(Date:9/15/2014)... UPTON, NYHeat drives classical phase transitionsthink solid, ... happen when the temperature drops. If phase ... where quantum mechanics reigns, subtle fluctuations can ... from the U.S. Department of Energy,s Brookhaven ... explored this frigid landscape of absolute zero ...
(Date:9/15/2014)... 2014   Global Science & Technology, Inc. ... and services for satellite and weather systems, was ... Services (OASIS) from the General Services Administration (GSA) ... provide the government best-value solutions for complex professional ... in Pool 4. The OASIS SB award has ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Global Wellness Company Hosts ASEA Australia Tour September 16-22 2Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3
... EDMONTON, Sept. 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. ... company developing and commercializing products for the treatment ... a pipeline of late-stage immunotherapy product candidates from ... of product candidates consists of five monoclonal antibodies ...
... ... , ... (PRWEB) September 30, 2009 -- Authenware , a leading keystroke biometric developer, today ... with software-based biometric protection for its federal employees. Calculating intrinsic behavioral typing patterns ...
... Inc. (Nasdaq: BMRN ) today announced that Jean-Jacques Bienaime, ... and webcast on Wednesday, October 28, at 5:00 p.m. ET ... U.S. / Canada Dial-in Number: 800.299.6183, ... Participant Code: 51404008, Replay Dial-in Number: 888.286.8010, ...
Cached Biology Technology:Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 2Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 3Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 4Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 2Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 3BioMarin to Host Third Quarter 2009 Financial Results Conference Call and Webcast on Wednesday, October 28 at 5:00 p.m. ET 2
Phospho-TAO2 (S181) Affinity Purified Polyclonal Ab Protein Family: Other Intracellular Kinases...
PEG 8000, Molecular Biology Grade...
... Deacetylase (HDAC) Antibody Sampler Kit Kit ... Catalog #2062, 40 ul Histone Deacetylase 3 ... Deacetylase 4 (HDAC4) Antibody, Catalog #2072, 40 ... #2082, 40 ul Histone Deacetylase 6 (HDAC6) ...
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: