Navigation Links
Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition

Dr. Mara ngeles Mena, Researcher at Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Director of the Neuropharmacology Laboratory at Hospital Ramn y Cajal (Madrid, Spain), coordinated the study performed by predoctoral student Juan Perucho and others.

The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice" confirms that anesthesia is safe for normal mice but potentially harmful for mice with genetic risk factors for Alzheimer's disease (AD).

Over several months, investigations have focused on analyzing the effects of the anesthesia in normal mice and in mice with mutations that produce AD.

Madrid, March 16, 2010.- The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria ngeles Mena and Justo Garca de Ybenes, from CIBERNED (Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas). The work has been published in an authoritative publication in this area of pathology: Journal of Alzheimer's Disease. Other participants in the study are Juan Perucho, Isabel Rubio, Mara J. Casarejos, Ana Gmez, Jos A. Rodrguez-Navarro, Rosa M. Solano, from the Neurobiology and Neurology Departments at Hospital Ramn y Cajal in Madrid.

The findings suggest a possible mechanism of developing Alzheimer. Some epidemiological studies have shown an increased prevalence of AD in patients undergoing anesthesia and surgery. Doctor Justo Garca de Ybenes states that "before surgery requiring anesthesia, it may be ideal to know the genetic background of the patients so that the drugs used and the pattern of anesthesia may be personalized accordingly."

The linkage between the repetitive use of isoflurane anesthesia and the development of AD changes in mice with mutations indicates the advisability of testing for genetic risk factors for AD in patients prior to surgery. Until recently, the most important genetic risk factor for AD was the presence of the allele E4 of the apolipoprotein E, but recently other genetic polymorphisms of risks have been identified. Once these polymorphisms of risks are identified and their relative impact on the pathogenesis of AD are known, a simple, automatic test for risk of AD should be performed in patients, namely the elderly, undergoing surgery under general anesthesia and the anesthetic procedure should be modified accordingly. A personalized clinical model that would enable the reduction of the patient's potential risk for AD would reduce the risk of anesthesia.

Study conclusions:

The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice", confirms that anesthesia is safe for normal mice but risky for asymptomatic carriers of mutations wich produce AD.

The research has been based on the application of anesthesia twice a week during three months in normal mice and in mice with mutations (7-10 months old) that produce AD (known as APPswe ). The results show alterations produced in the brain of mice with mutations very similar to those observed in patients that have already developed Alzheimer's disease.

Study highlights:

  • Application of repetitive anesthesia in genetically altered mice increased their death rate.
  • Mutant mice showed less reactivity after anesthesia was over. Their time for recovery after anesthesia was also increased.
  • Repetitive anesthesia produced persistent disorders affecting behavior of mutant mice.
  • Neuronal death increased in brain areas critical for cognition.
  • Increased inflammatory response and deposition of beta-amyloid peptides.
  • Isoflurane anesthesia of mutant mice altered the levels of chaperones (proteins which regulate the processing of abnormal proteins)

AD usually is the main cause of dementia for people over 65

Currently, over 5 million people in the first world suffer from AD, a neurodegenerative pathology that lacks a specific diagnostic test. The prevalence of this disease is also increasing in developing countries. Currently, there is no therapy that stops or reverts the progression of AD, although there are several treatments that partially improve symptoms. Researchers predict that Spain will experience a 75% increase of AD patients in 25 years.

Memory loss, language problems, incapacity for decision making and discernment are some of the main traits of this disease.


Contact: Raquel Lumbreras
IOS Press

Related biology news :

1. Anesthesia and Alzheimers
2. Study finds Viagra increases release of key reproductive hormone
3. Springer increases publishing activities in South Korea
4. Age increases chance of success as two-timer
5. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
6. Waterborne carbon increases threat of environmental mercury
7. New study increases concerns about climate model reliability
8. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
9. Washington University increases fleet of Roche Genome Sequencer FLX Systems
10. Gene variant increases breast cancer risk
11. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
Post Your Comments:
(Date:9/30/2015)... 2015  With nearly 300,000 Americans living with spinal ... estimated to reach 12,500 annually, the role of Independent ... for Independent Living (SCRS-IL) is increasingly important. SCRS-IL ... opening doors to independence for individuals with ... notably assistive technology services and education. "In ...
(Date:9/29/2015)... 2015 News facts: ... saving energy , Minimized design shrinks PC footprint ... Mode and embedded Fujitsu PalmSecure authentication enable enterprises to ... today shows that good things come in small packages, ... its enterprise desktop and mobile portfolio. Featuring workplace design ...
(Date:9/28/2015)... NEW YORK , Sept. 28, 2015 /PRNewswire/ ... rate, respiration rate and body temperature, is an ... signs can be indicators of deterioration in a ... the hospital, vital signs are typically taken during ... eight hours. If a patient deteriorates between these ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... ... , ... Clinovo recently appointed Jeff Parr and Ed Donaldson to its Business ... business. , Jeff Parr has spent the past decade providing quality management software and ... and Ab Sciex to name a few. He is based in Salt Lake ...
(Date:10/13/2015)... -- the United States , ... about 14% of all new cases of kidney cancer.   ... and Europe .  PRCC represents about ... Hutchison China MediTech Limited ("Chi-Med") (AIM: HCM) today announces that ... (publ) ("AstraZeneca") have completed enrolment in a global Phase II study ...
(Date:10/12/2015)... NEW YORK , Oct. 12, 2015 ... its segments, which include cell type, products, applications, end-user ... REPORT HIGHLIGHTS The global cell expansion ... and is expected to reach revenues of $9.7 billion ... compound annual growth rate (CAGR) of 17.8% from 2015 ...
(Date:10/12/2015)... 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: ... developing and commercializing novel treatments in oncology, endocrinology and ... Turpin , the Company,s former Senior Vice President, Chief ... Quebec City office.  ... Officer of the Company commented, "After a comprehensive review, ...
Breaking Biology Technology: