Navigation Links
Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition
Date:3/24/2010

Dr. Mara ngeles Mena, Researcher at Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Director of the Neuropharmacology Laboratory at Hospital Ramn y Cajal (Madrid, Spain), coordinated the study performed by predoctoral student Juan Perucho and others.

The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice" confirms that anesthesia is safe for normal mice but potentially harmful for mice with genetic risk factors for Alzheimer's disease (AD).

Over several months, investigations have focused on analyzing the effects of the anesthesia in normal mice and in mice with mutations that produce AD.

Madrid, March 16, 2010.- The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria ngeles Mena and Justo Garca de Ybenes, from CIBERNED (Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas). The work has been published in an authoritative publication in this area of pathology: Journal of Alzheimer's Disease. Other participants in the study are Juan Perucho, Isabel Rubio, Mara J. Casarejos, Ana Gmez, Jos A. Rodrguez-Navarro, Rosa M. Solano, from the Neurobiology and Neurology Departments at Hospital Ramn y Cajal in Madrid.

The findings suggest a possible mechanism of developing Alzheimer. Some epidemiological studies have shown an increased prevalence of AD in patients undergoing anesthesia and surgery. Doctor Justo Garca de Ybenes states that "before surgery requiring anesthesia, it may be ideal to know the genetic background of the patients so that the drugs used and the pattern of anesthesia may be personalized accordingly."


'/>"/>

Contact: Raquel Lumbreras
Raquel_lumbreras@duomocomunicacion.com
34-913-119-289
IOS Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Anesthesia and Alzheimers
2. Study finds Viagra increases release of key reproductive hormone
3. Springer increases publishing activities in South Korea
4. Age increases chance of success as two-timer
5. Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
6. Waterborne carbon increases threat of environmental mercury
7. New study increases concerns about climate model reliability
8. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
9. Washington University increases fleet of Roche Genome Sequencer FLX Systems
10. Gene variant increases breast cancer risk
11. Ibuprofen or acetaminophen in long-term resistance training increases muscle mass/strength
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... City of Entiat on Tuesday, July 8, 2014. Despite ... to over 1,000 acres by evening. Three outbuildings were ... by the Washington Department of Natural Resources. The ... developing fire control strategies and tactics. Other cooperators include ... Natural Resources, (WA DNR), Bureau of Land Management, Chelan ...
(Date:7/11/2014)... of Standards and Technology (NIST) need a special ... often prove that necessity is truly the mother ... M. Lorna De Leoz and Stephen Stein, NIST ... Glycomics is the study of the abundant, often-branched ... proteins and lipids and influence cellular processes, including ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... since scientists first discovered the gene that causes cystic ... causes disease remain unanswered. Using a newly created ... of cystic fibrosis, University of Iowa researchers have now ... pigs and does not end up in the correct ...
... observe behavior in fossil specimens that are dead even ... modern, living, species that has some similarities to the ancient ... University of Cincinnati professor of geology and colleagues as they ... they resemble clams or other shelled mollusks, brachiopods are more ...
... edition of the journal Fungal Biology Reviews , published ... a total of 76 videos which together comprise the most ... movies were produced by Professor Gero Steinberg of the University ... field of fungal cell biology. The editors of ...
Cached Biology News:Pig model of cystic fibrosis improves understanding of disease 2Pig model of cystic fibrosis improves understanding of disease 3Paleontologists audition modern examples of ancient behavior 2
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
(Date:7/10/2014)... psychiatric disorders has been extremely challenging because there are ... insufficient to cause disease. Now investigators reporting in the ... Cell Stem Cell describe a strategy that may ... other risk factors or environmental exposures to affect the ... genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... 15 3SBio Inc. (Nasdaq:,SSRX), a leading China-based ... biopharmaceutical products, today,announced the results of the shareholder ... held on September 12, 2008 (Friday) at 10:00 ... shareholders re-elected Dr. Jing Lou,Liping Xu, Bin Huang, ...
... Plans to Phase in Routine Vaccination Program ... and Young Children -, COLLEGEVILLE, Pa., Sept. ... WYE ), today announced that,South Africa has ... (Pneumococcal Saccharide Conjugated Vaccine,Adsorbed), a vaccine which helps ...
... Biopharma,Inc. (OTC Bulletin Board: CBPC) announced today that it ... of Delaware an amendment to its Certificate,of Incorporation to ... common stock ("Common Stock") will begin trading on a,reverse-split ... CHBO., By unanimous written consent dated July 3, ...
Cached Biology Technology:South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 2South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 3South Africa Begins Introduction of PREVENAR into Childhood Immunization Program 4China Biopharma Effects 1 for 100 Reverse Stock Split 2China Biopharma Effects 1 for 100 Reverse Stock Split 3