Dr. Mara ngeles Mena, Researcher at Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas (CIBERNED) and Director of the Neuropharmacology Laboratory at Hospital Ramn y Cajal (Madrid, Spain), coordinated the study performed by predoctoral student Juan Perucho and others.
The study "Anesthesia with isoflurane increases long lasting behavioral changes and amyloid pathology of Alzheimer's disease in mice" confirms that anesthesia is safe for normal mice but potentially harmful for mice with genetic risk factors for Alzheimer's disease (AD).
Over several months, investigations have focused on analyzing the effects of the anesthesia in normal mice and in mice with mutations that produce AD.
Madrid, March 16, 2010.- The use of repetitive anesthesia with isoflurane (one of the most common anesthetics by inhalation) increases the risk of developing changes similar to those observed in AD brains in mice with mutations of the amyloid precursor protein (APP). This is the main conclusion of Spanish researchers coordinated by Doctors Maria ngeles Mena and Justo Garca de Ybenes, from CIBERNED (Centro de Investigacin Biomdica en Red de Enfermedades Neurodegenerativas). The work has been published in an authoritative publication in this area of pathology: Journal of Alzheimer's Disease. Other participants in the study are Juan Perucho, Isabel Rubio, Mara J. Casarejos, Ana Gmez, Jos A. Rodrguez-Navarro, Rosa M. Solano, from the Neurobiology and Neurology Departments at Hospital Ramn y Cajal in Madrid.
The findings suggest a possible mechanism of developing Alzheimer. Some epidemiological studies have shown an increased prevalence of AD in patients undergoing anesthesia and surgery. Doctor Justo Garca de Ybenes states that "before surgery requiring anesthesia, it may be ideal to know the genetic background of the patients so that the drugs used and the pattern of anesthesia may be personalized accordingly."
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