Navigation Links
Ancient remains put teeth into Barker hypothesis
Date:2/4/2010

Ancient human teeth are telling secrets that may relate to modern-day health: Some stressful events that occurred early in development are linked to shorter life spans.

"Prehistoric remains are providing strong, physical evidence that people who acquired tooth enamel defects while in the womb or early childhood tended to die earlier, even if they survived to adulthood," says Emory University anthropologist George Armelagos.

Armelagos led a systematic review of defects in teeth enamel and early mortality recently published in Evolutionary Anthropology. The paper is the first summary of prehistoric evidence for the Barker hypothesis the idea that many adult diseases originate during fetal development and early childhood.

"Teeth are like a snapshot into the past," Armelagos says. "Since the chronology of enamel development is well known, it's possible to determine the age at which a physiological disruption occurred. The evidence is there, and it's indisputable."

The Barker hypothesis is named after epidemiologist David Barker, who during the 1980s began studying links between early infant health and later adult health. The theory, also known as the Developmental Origins of Health and Disease Hypothesis (DOHaD), has expanded into wide acceptance.

As one of the founders of the field of bioarcheology, Armelagos studies skeletal remains to understand how diet and disease affected populations. Tooth enamel can give a particularly telling portrait of physiological events, since the enamel is secreted in a regular, ring-like fashion, starting from the second trimester of fetal development. Disruptions in the formation of the enamel, which can be caused by disease, poor diet or psychological stress, show up as grooves on the tooth surface.

Armelagos and other bioarcheologists have noted the connection between dental enamel and early mortality for years. For the Evolutionary Biology paper, Armelagos led a review of the evidence from eight published studies, applying the lens of the Barker hypothesis to remains dating back as far as 1 million years.

One study of a group of Australopithecines from the South African Pleistocence showed a nearly 12-year decrease in mean life expectancy associated with early enamel defects. In another striking example, remains from Dickson Mounds, Illinois, showed that individuals with teeth marked by early life stress lived 15.4 years less than those without the defects.

"During prehistory, the stresses of infectious disease, poor nutrition and psychological trauma were likely extreme. The teeth show the impact," Armelagos says.

Until now, teeth have not been analyzed using the Barker hypothesis, which has mainly been supported by a correlation between birth weight in modern-day, high-income populations and ailments like diabetes and heart disease.

"The prehistoric data suggests that this type of dental evidence could be applied in modern populations, to give new insights into the scope of the Barker hypothesis," Armelagos says. "Bioarcheology is yielding lessons that are still relevant today in the many parts of the world in which infectious diseases and under-nutrition are major killers."


'/>"/>

Contact: Beverly Clark
beverly.clark@emory.edu
404-712-8780
Emory University
Source:Eurekalert

Related biology news :

1. Scientists retrace evolution with first atomic structure of an ancient protein
2. CU-Boulder team discovers first ancient manioc fields in Americas
3. Ancient organisms discovered in Canadian gold mine
4. Amber specimen captures ancient chemical battle
5. Ancient whale fall from Californias Año Nuevo Island one of youngest, most complete known
6. Ancient whale fall from Californias Ao Nuevo Island one of youngest, most complete known
7. 454 Sequencing: Science paper describes a novel, highly efficient method of sequencing ancient DNA
8. Newfound ancient African megadroughts may have driven the evolution of humans and fishes
9. Ancient amphibians left full-body imprints
10. Scientists melt million-year-old ice in search of ancient microbes
11. Ancient fish bones reveal impacts of global warming beneath the sea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: