Ancient protein offers clues to killer...(folding is of fundamental functional imp...)

In humans, any changes in the composition of myosin within the muscles can be fatal. For example, a swelling in the walls of an artery can cause a brain aneurism, while an enlarged heart can lead to cardiac arrest in a young, fit person.

Says Professor Knight: Because these malfunctions occur in our internal organs, we are often unaware of what is going wrong until its too late. Learning how to control myosin, how to move it around without disturbing the delicate balance between filaments and individual molecules, is an emerging area and one we are only just beginning to tackle.

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