Navigation Links
Analyzing disease transmission at the community level

Researchers at the Johns Hopkins Bloomberg School of Public Health have found evidence of a role for neighborhood immunity in determining risk of dengue infection. While it is established that immunity can be an important factor in the large-scale distribution of disease, this study demonstrates that local variation at spatial scales of just a few hundred meters can significantly alter the risk of infection, even in a highly mobile and dense urban population with significant immunity. The study is published in May 28 edition of the journal PNAS.

Dengue is a mosquito-borne disease that infects nearly 50 million people worldwide each year, resulting in more than 19,000 deaths. There are four serotypes of dengue virus (DENV1) circulating in Bangkok, Thailand, where the study was conducted. Infection with dengue provides lifelong immunity to the infecting serotype and there is evidence infection temporarily protects from infection by other serotypes. When susceptibility to other serotypes returns there is an increased risk for severe disease. For the study, the research team used the household location of 1,912 confirmed dengue cases in Bangkok that were admitted to a local children's hospital between 1995 and 2000. The available data enabled the researchers to pair dengue serotype infections with specific households.

Observations indicated that immunological memory of dengue serotypes occurs at the neighborhood level in this large urban setting. The researchers developed methods that have broad application to studying the spatiotemporal structure of disease risk where pathogen serotype or genetic information is known.

"We observe patterns of spatiotemporal dependence consistent with the expected impacts of lifelong and short-term immunity, and immune enhancement of disease at distances of under one kilometer," said Henrik Salje, lead author of the study and doctoral candidate in the Bloomberg School's Department of Epidemiology.

"By providing insight into the potential spatial scales that immunity in a population is correlated and distances over which the disease is dispersed, these findings can help us further understand how dengue is being maintained in endemic populations," said the study's senior author, Derek Cummings, PhD, assistant professor with the Bloomberg School's departments of Epidemiology and International Health.

Contact: Tim Parsons
Johns Hopkins University Bloomberg School of Public Health

Related biology news :

1. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
2. Analyzing complex plant genomes with the newest next-generation DNA sequencing techniques
3. Analyzing the sheep genome for parasite resistance
4. Analyzing agroforestry management
5. Analyzing long-term impacts of biofuel on the land
6. NSF awards $10M to develop computing techniques for measuring and analyzing child behavior
7. Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket
8. Engineered microvessels provide a 3-D test bed for human diseases
9. Tongue analysis software uses ancient Chinese medicine to warn of disease
10. Army study: DNA vaccine and duck eggs protect against hantavirus disease
11. New study shows how nanotechnology can help detect disease earlier
Post Your Comments:
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
(Date:11/12/2015)... , Nov. 12, 2015  A golden retriever that ... muscular dystrophy (DMD) has provided a new lead for ... Hospital, the Broad Institute of MIT and Harvard and ... . Cell, pinpoints a ... "escape" the disease,s effects. The Boston Children,s lab of ...
(Date:11/11/2015)... , Nov. 11, 2015   MedNet Solutions , ... spectrum of clinical research, is pleased to announce that it ... Clinical Trials (PCT) event, to be held November 17-19 ... able to view live demonstrations of iMedNet ... learn how iMedNet has been able to deliver ...
Breaking Biology News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... --> Accutest Research Laboratories, a ... Research Organization (CRO), has formed a ... Center - Temple Health for joint ... ,     (Photo: ) , ...
(Date:11/25/2015)... , Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: ... adopted a stockholder rights plan (Rights Plan) in an ... loss carryforwards (NOLs) under Section 382 of the Internal ... --> PharmAthene,s use of its NOLs could be ... as defined in Section 382 of the Code. In ...
(Date:11/25/2015)... and HOLLISTON, Mass. , ... Inc. (Nasdaq: HART ), a biotechnology company developing ... CEO Jim McGorry will present at the ... 1, 2015 at 2:30 p.m. PT. The presentation will ... for 30 days. Management will also be available at ...
(Date:11/25/2015)... ... November 25, 2015 , ... A long-standing partnership ... Professionals (OPBAP) has been formalized with the signing of a Memorandum of Understanding. ... OPBAP leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, ...
Breaking Biology Technology: