Navigation Links
Analytica Research Prize for Dr. Matthias Selbach of MDC
Date:3/23/2010

Dr. Matthias Selbach, biologist at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, has been honored with the Analytica Research Prize 2010 in an award ceremony at the Analytica 2010 trade fair in Munich. Dr. Selbach received the prize, which is endowed with 25 000 euros, for his work on "the impact of microRNAs on protein production in cancer cells" on March 23, 2010. The prize is awarded by the Society for Biochemistry and Molecular Biology (GBM) and funded by Roche.

Proteins play a key role in practically every cell activity: Whether they transport oxygen, make muscles move or digest food proteins are the chief actors in almost all biological processes. The "blueprint" for proteins is encoded in the genes. But although all cells of the body have the same genes, they produce quite different proteins. How then is the production of these different proteins regulated? Hitherto, scientists have devoted much effort to investigate each protein individually.

In their laboratory in Berlin, Dr. Selbach and his research team have now developed a new approach enabling them to measure the production of thousands of proteins simultaneously. The method involves labeling the amino acids, the building blocks of proteins, with stable isotopes.

The cells then incorporate the isotope-labeled amino acids into the proteins. As a following step, the scientists quantify the protein synthesis using a mass spectrometer.

Only a few years ago, researchers discovered that microRNAs play an important role in gene regulation. microRNAs are tiny pieces of ribonucleic acid, a chemical relative of DNA. microRNAs also determine which proteins are produced by which cells.

If the regulation goes awry, this can lead to many diseases. Scientists across the globe are therefore seeking to develop methods to detect which microRNAs are active in the body's cells and which proteins are regulated by them.

But exactly which proteins does a specific microRNA regulate? To solve this question, the research teams of Dr. Selbach and Professor Nikolaus Rajewsky at the Max Delbrck Center have joined forces.

Using the novel analytical approach they developed, the MDC researchers for the first time were able to quantify the influence of microRNAs on protein production.

They discovered that a single microRNA can regulate synthesis of hundreds of proteins. In this way microRNAs can program the behavior of human cells.

Since in cancer cells different microRNAs are active than in healthy cells, microRNAs are considered to be promising candidates for diagnostics and therapy. Therefore, the researchers' findings are anticipated to have a great impact in the future.

Matthias Selbach was born in Dsseldorf in 1971 and studied biology in Mnster. He wrote his dissertation at the Max Planck Institute (MPI) for Infection Biology in Berlin and received his PhD degree from Humboldt University Berlin. He then worked at the Center for Experimental Bioinformatics at the University of South Denmark in Odense and at the MPI for Biochemistry in Martinsried. Since 2007 he leads the research group "Cellular Signalling and Mass Spectrometry" at the MDC in Berlin-Buch.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services
2. New bioanalytical methods have potential for investigative and screening applications
3. Research shows skeleton to be endocrine organ
4. Newly created cancer stem cells could aid breast cancer research
5. Dominant cholesterol-metabolism ideas challenged by new research
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. Texas researchers and educators head for Antarctica
8. MGH researchers describe new way to identify, evolve novel enzymes
9. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
10. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
11. U of MN researchers discover noninvasive diagnostic tool for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems ... seamlessly log work hours, for employers to make sure the right employees are actually ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/2/2016)... , June 2, 2016 The Department ... has awarded the 44 million US Dollar project, for the ... Vehicle Plates including Personalization, Enrolment, and IT Infrastructure , ... in the production and implementation of Identity Management Solutions. Numerous ... however Decatur was selected for the ...
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled ... medical LCD display is the latest premium product recently added to the range of ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
Breaking Biology News(10 mins):
(Date:12/2/2016)...  The Multiple Myeloma Research Foundation (MMRF) today announced ... SM —the largest and most comprehensive study driving new ... be presented at the 58 th American Society ... San Diego from December 3-6. The ... well as identify pathways and targets for new drug ...
(Date:12/2/2016)... ... 01, 2016 , ... ACEA Biosciences, Inc. announced today that it will be ... at the World Conference on Lung Cancer 2016, taking place in Vienna, Austria December ... clinical trials for AC0010 in patients with advanced non-small cell lung cancer harboring the ...
(Date:12/2/2016)... ... ... The Conference Forum has announced that the 3rd annual Immuno-Oncology 360° ... 1-3, 2017 at the Roosevelt Hotel in New York City. Led by advisors Dr ... approach, which addresses the most up-to-date information regarding business aspects, clinical advancements and scientific ...
(Date:12/2/2016)... ... ... Robots will storm the Prudential Center in Boston, MA during the ... held on the United Nations International Day of Persons with Disabilities, will highlight the ... Technologies is partnering with NTI to showcase how technology can help individuals with severe ...
Breaking Biology Technology: