Navigation Links
Analytica Research Prize for Dr. Matthias Selbach of MDC
Date:3/23/2010

Dr. Matthias Selbach, biologist at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch, Germany, has been honored with the Analytica Research Prize 2010 in an award ceremony at the Analytica 2010 trade fair in Munich. Dr. Selbach received the prize, which is endowed with 25 000 euros, for his work on "the impact of microRNAs on protein production in cancer cells" on March 23, 2010. The prize is awarded by the Society for Biochemistry and Molecular Biology (GBM) and funded by Roche.

Proteins play a key role in practically every cell activity: Whether they transport oxygen, make muscles move or digest food proteins are the chief actors in almost all biological processes. The "blueprint" for proteins is encoded in the genes. But although all cells of the body have the same genes, they produce quite different proteins. How then is the production of these different proteins regulated? Hitherto, scientists have devoted much effort to investigate each protein individually.

In their laboratory in Berlin, Dr. Selbach and his research team have now developed a new approach enabling them to measure the production of thousands of proteins simultaneously. The method involves labeling the amino acids, the building blocks of proteins, with stable isotopes.

The cells then incorporate the isotope-labeled amino acids into the proteins. As a following step, the scientists quantify the protein synthesis using a mass spectrometer.

Only a few years ago, researchers discovered that microRNAs play an important role in gene regulation. microRNAs are tiny pieces of ribonucleic acid, a chemical relative of DNA. microRNAs also determine which proteins are produced by which cells.

If the regulation goes awry, this can lead to many diseases. Scientists across the globe are therefore seeking to develop methods to detect which microRNAs are active in the body's cells and which proteins are regulated by them.

But exactly which proteins does a specific microRNA regulate? To solve this question, the research teams of Dr. Selbach and Professor Nikolaus Rajewsky at the Max Delbrck Center have joined forces.

Using the novel analytical approach they developed, the MDC researchers for the first time were able to quantify the influence of microRNAs on protein production.

They discovered that a single microRNA can regulate synthesis of hundreds of proteins. In this way microRNAs can program the behavior of human cells.

Since in cancer cells different microRNAs are active than in healthy cells, microRNAs are considered to be promising candidates for diagnostics and therapy. Therefore, the researchers' findings are anticipated to have a great impact in the future.

Matthias Selbach was born in Dsseldorf in 1971 and studied biology in Mnster. He wrote his dissertation at the Max Planck Institute (MPI) for Infection Biology in Berlin and received his PhD degree from Humboldt University Berlin. He then worked at the Center for Experimental Bioinformatics at the University of South Denmark in Odense and at the MPI for Biochemistry in Martinsried. Since 2007 he leads the research group "Cellular Signalling and Mass Spectrometry" at the MDC in Berlin-Buch.


'/>"/>

Contact: Barbara Bachtler
bachtler@mdc-berlin.de
49-309-406-3896
Helmholtz Association of German Research Centres
Source:Eurekalert

Related biology news :

1. Microtest Labs Adds Dissolution Testing to its Suite of Analytical and Stability Testing Services
2. New bioanalytical methods have potential for investigative and screening applications
3. Research shows skeleton to be endocrine organ
4. Newly created cancer stem cells could aid breast cancer research
5. Dominant cholesterol-metabolism ideas challenged by new research
6. Researchers identify proteins involved in new neurodegenerative syndrome
7. Texas researchers and educators head for Antarctica
8. MGH researchers describe new way to identify, evolve novel enzymes
9. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
10. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
11. U of MN researchers discover noninvasive diagnostic tool for brain diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour ... from the Q1 wave of its quarterly wearables survey. ... receptivity to a program where they would receive discounts ... company. "We were surprised to see that ... LaColla , CEO of Troubadour Research, "primarily because there ...
(Date:4/26/2016)... LONDON , April 26, 2016 /PRNewswire/ ... Systems, a product subsidiary of Infosys (NYSE: ... partnership to integrate the Onegini mobile security platform ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration ... security to access and transact across channels. Using ...
(Date:4/14/2016)... , April 14, 2016 ... Malware Detection, today announced the appointment of Eyal ... new role. Goldwerger,s leadership appointment comes at ... heels of the deployment of its platform at several ... biometric technology, which discerns unique cognitive and physiological factors, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
Breaking Biology Technology: