Navigation Links
Analysis of millions of US births shows association between birth defects and preterm birth

MAY 21, 2008, WHITE PLAINS, NY Babies born preterm were more than twice as likely to have major birth defects as full-term infants, according to a new analysis of nearly 7 million U.S. live births published online this week in the Springer journal Maternal and Child Health Journal.

Preterm birth, live birth before 37 completed weeks gestation, is a growing national health crisis, according to the March of Dimes. More than a half million babies are born too soon each year, and the rate continues to rise. Birth defects and preterm birth are the leading causes of infant death.

About 8 percent of babies born preterm had a birth defect, according to the research by a team of investigators from the March of Dimes, the U.S. Centers for Disease Control and Prevention (CDC), and several other major institutions.

For this study, the researchers looked at live births between 1995 and 2000 from 13 states, representing about 30 percent of all U.S. births. The findings supported those of earlier, smaller studies.

The causes of most birth defects are still not known, says Margaret Honein, PhD, MPH of the CDCs National Center on Birth Defects and Developmental Disabilities and lead author of the study. While it is likely that the most common defects are caused by a combination of genetic and environmental factors, the identification of specific risk factors continues to be a major research and public health priority.

Research into the link between birth defects and preterm birth was called for in the PREEMIE Act (P.L. 109-450) that was signed into law in December 2006. The act, which authorized increased federal support for research and education on prematurity, also called for a Surgeon Generals Conference, scheduled for June 2008, to establish a public-private agenda on premature birth.

Infants born preterm were more than twice as likely to have major birth defects as infants born at term, and the association was strongest among very preterm babies, said Joann Petrini, PhD, MPH, director of the March of Dimes Perinatal Data Center, who also co-authored the study. This study highlights the importance of understanding the possible shared causes and risk factors that lead to preterm birth among those infants affected by major birth defects.

Very preterm babies, those born between 24 and 31 weeks gestation, were five times as likely as full-term infants to have a birth defect. The most common birth defects for this group were central nervous system defects, such as spina bifida, and cardiovascular defects, such as a hole in the heart.


Contact: Elizabeth Lynch
March of Dimes Foundation

Related biology news :

1. Bitter orange SRMs: Tools for product analysis/quality
2. A new analysis method allows to find out the sex of the baby from the second month of pregnancy
3. First analysis of platypus genome may impact disease prevention
4. Analysis of RNA role in spreading disease advances study of damaging plant infections
5. Antioxidant users dont live longer, analysis of studies concludes
6. Preliminary DNA analysis completed on California wolverine
7. Isotope analysis reveals foraging area dichotomy for Atlantic leatherback turtles
8. Surprising discovery from first large-scale analysis of biodiversity and biogeography of viruses
9. New UC analysis shows alarming increase in expected growth of Chinas carbon dioxide emissions
10. Alarming growth in expected CO2 emissions in China, finds UC analysis
11. DOE JGI releases a new version of its metagenome data management and analysis system
Post Your Comments:
(Date:10/29/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce that it has been selected ... of only three finalists for a 2015 Tekne ... category. The Tekne Awards honor Minnesota ... and leadership. iMedNet™ eClinical  technology ...
(Date:10/29/2015)... ARBOR, Mich. , Oct. 29, 2015 /PRNewswire/ ... Eurofins Genomics for U.S. distribution of its DNA ... DNA-seq kit and Rubicon,s new ThruPLEX Plasma-seq kit. ... to enable the preparation of NGS libraries for ... plasma for diagnostic and prognostic applications in cancer ...
(Date:10/29/2015)... YORK , Oct. 29, 2015 ... technology, announced a partnership with 2XU, a global ... to deliver a smart hat with advanced bio-sensing ... and other athletes to monitor key biometrics to ... the strategic partnership, the two companies will bring together ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 26, 2015 --> ... 2016 - 2020 report analyzes that automating biobanking ... quality in long-term samples, minimizing manual errors, improving ... minimizes manual errors such as mislabeling or inaccurate ... it plays a vital role in blood fractionation, ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... HART ), a biotechnology company developing bioengineered organ implants ... McGorry will present at the LD Micro "Main ... 2:30 p.m. PT. The presentation will be webcast live ... Management will also be available at the conference for ...
(Date:11/25/2015)... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ) ... chat discussion at the Piper Jaffray 27th Annual Healthcare ... discussion is scheduled for Wednesday, December 2, at 8:00 ... replay will be available for 14 days after the ... NormartVP, Corporate Communications and Business Development , BrewLife(858) 875-8629 ...
(Date:11/24/2015)... , ... November 24, 2015 , ... The United States ... of the 2016 USGA Green Section Award. Presented annually since 1961, the USGA Green ... or her work with turfgrass. , Clarke, of Iselin, N.J., is an ...
Breaking Biology Technology: