Navigation Links
Analysis of Lake Washington microbes shows the power of metagenomic approaches
Date:8/17/2008

WALNUT CREEK, CAToday's powerful sequencing machines can rapidly read the genomes of entire communities of microbes, but the challenge is to extract meaningful information from the jumbled reams of data. In a paper appearing in Nature Biotechnology August 17, a collaboration headed by researchers at the University of Washington and the U.S. Department of Energy Joint Genome Institute (DOE JGI) describes a novel approach for extracting single genomes and discerning specific microbial capabilities from mixed community ("metagenomic") sequence data.

For the first time, using an enrichment technique applied to microbial community samples, the research team explored the sediments in Lake Washington, bordering Seattle, WA and characterized biochemical pathways associated with nitrogen cycling and methane utilization, important for understanding methane generation and consumption by microbes. Methane is both a greenhouse gas and a potential energy source.

"Even if you have lots of sequence, for complex communities it still doesn't tell you which organism is responsible for which function," said the paper's senior author Ludmila Chistoserdova, a microbiologist at the University of Washington. "This publication presents an approach, via simplification and targeted metagenomic sequencing, of how you can go after the function in the environment."

Chistoserdova and colleagues study microbes that oxidize single-carbon compounds such as methane, methanol and methylated amines, which are compounds contributing to the greenhouse effect and are part of the global carbon cycle.

"To utilize these single-carbon compounds, organisms employ very specialized metabolism," said Chistoserdova. "We suspect that in the environment, there are novel versions of this metabolism, and possibly completely novel pathways."

Most of the microbes that oxidize single-carbon compounds are unculturable and therefore unknown, as are the vast majorit
'/>"/>

Contact: David Gilbert
degilbert@lbl.gov
925-296-5643
DOE/Joint Genome Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Ginkgo SRMs: Tools for product analysis/quality
2. DNA analysis shows true dispersal of protozoa
3. Interacting protein theory awaits test from new neutron analysis tools
4. Analysis of breast and colon cancer genes finds many areas of differences between tumors
5. Tumor genome analysis unveils new insights into lung cancer
6. Powerful integration of lipid metabolic profiling with gene expression analysis
7. Human clones: New U.N. analysis lays out worlds choices
8. More comprehensive analysis of Klamath River basin needed to aid decision makers
9. Analysis calls for medical device information to better serve patients and doctors
10. Avian origins: new analysis confirms ancient beginnings
11. DOE JGI releases a new version of its metagenome data management and analysis system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... the fish world, are the ideal animal in which ... moved from the ocean into tens of thousands of ... changing their skeleton to adapt to the new environment. ... sticklebacks now have turned up one of the genes ... change in that gene,s regulation in a freshwater population ...
(Date:9/18/2014)... has found clownfish larvae can swim up to 400 kilometres ... to cope with environmental change. , Clownfish spend their entire ... as babies they must wander the open ocean, says study ... for Coral Reef Studies (Coral CoE) at James Cook University. ... but now we,ve been given a rare glimpse into how ...
(Date:9/17/2014)... From accessible and affordable health care to reproductive ... depend on the ability of people to identify ... openly and respectfully, and find the most defensible ... practices to support these societal conversations?, The Hastings ... of Bioethical Issues have teamed up to publish ...
Breaking Biology News(10 mins):Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3Nemo's epic journey to find a new home 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... Researchers at the University of Pennsylvania School of ... with an increased risk of testicular cancer. Testicular cancer is ... among non-Hispanic Caucasian men has doubled in the last 40 ... men in the United States each year. The discovery, published ...
... Carolina State University engineers have created a non-toxic "wrinkled" ... of troublesome barnacles during 18 months of seawater tests, ... of dollars in cleaning and fuel costs. The ... in the Department of Chemical and Biomolecular Engineering, and ...
... ultrafast laser pulses to slice off pieces of ... engineers at the University of Michigan have gained ... division. Their findings could help scientists better ... in plants, fungi, and animalsincluding those in the ...
Cached Biology News:Penn researchers discover genetic risk factor for testicular cancer 2Penn researchers discover genetic risk factor for testicular cancer 3Nontoxic hull coating resists barnacles, may save ship owners millions 2Slicing chromosomes leads to new insights into cell division 2
(Date:9/19/2014)... The new , Healthcare and Life Sciences Review , ... PharmaBoardroom.com for free download , looks beyond the ... in 2009, and the austerity measures that followed, to find ... of trouble. "Despite the crisis, Spain ... the general conditions to invest are favorable to the pharmaceutical ...
(Date:9/18/2014)... 2014 About POCT ... a clinical laboratory. It helps in making fast ... and medication. POCT is gaining popularity due to ... such as diabetes, heart disease, and obesity. It ... standardized to minimize errors during the diagnosis of ...
(Date:9/18/2014)... Mich. , Sept. 18, 2014  Health Enhancement Products, ... firm investigating early-stage algae bioactive compounds and metabolic processes, is ... the company,s board of directors. Ms. Nola E. Masterson ... investment advisor joined the board effective September 17, 2014. ... Masterson agree to join our board," states Andrew Dahl ...
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3POCT Market in China 2014-2018 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... Transgenomic, Inc. (OTC/BB: TBIO) announced today ... company,s high-sensitivity cancer mutation assays using two proprietary ... studies will be presented at the American Association ... April 2-6, 2011. "BLOCker-Sequencing and Ice ...
... New Haven, Conn.Fuel cells have been touted as a ... in everything from cars to computers. But ... their lack of endurance. Over time, the catalysts used ... the chemical reaction that converts fuel into electricity. In ...
... March 31, 2011 Reportlinker.com announces that ... in its catalogue: Molecular ... The technologies that constitute ... in situ hybridization (FISH), second-generation biochips and ...
Cached Biology Technology:Transgenomic, Inc. Presentations to Describe High-Sensitivity Detection of Cancer Biomarkers at the 2011 American Association for Cancer Research Meeting 2Transgenomic, Inc. Presentations to Describe High-Sensitivity Detection of Cancer Biomarkers at the 2011 American Association for Cancer Research Meeting 3Transgenomic, Inc. Presentations to Describe High-Sensitivity Detection of Cancer Biomarkers at the 2011 American Association for Cancer Research Meeting 4Novel nanowires boost fuel cell efficiency 2Reportlinker Adds Molecular Diagnostics Markets 2Reportlinker Adds Molecular Diagnostics Markets 3Reportlinker Adds Molecular Diagnostics Markets 4Reportlinker Adds Molecular Diagnostics Markets 5Reportlinker Adds Molecular Diagnostics Markets 6Reportlinker Adds Molecular Diagnostics Markets 7Reportlinker Adds Molecular Diagnostics Markets 8Reportlinker Adds Molecular Diagnostics Markets 9Reportlinker Adds Molecular Diagnostics Markets 10Reportlinker Adds Molecular Diagnostics Markets 11Reportlinker Adds Molecular Diagnostics Markets 12Reportlinker Adds Molecular Diagnostics Markets 13Reportlinker Adds Molecular Diagnostics Markets 14Reportlinker Adds Molecular Diagnostics Markets 15Reportlinker Adds Molecular Diagnostics Markets 16Reportlinker Adds Molecular Diagnostics Markets 17Reportlinker Adds Molecular Diagnostics Markets 18
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
... Development kit contains the basic components required ... measure natural and recombinant mouse Dickkopf homolog-1 ... Each kit contains sufficient materials to run ... that the following conditions are met: ...
HIV-1 TAT (vN-21)...
Presenilin-1, N-terminus....
Biology Products: