Navigation Links
Analysis of Ashkenazi Jewish genomes reveals diversity, history
Date:8/26/2010

ainst malaria. Some scientists have proposed that disease-related mutations have persisted in the Ashkenazi Jewish population because of a similar hidden positive effect.

"Only six of the 21 disease genes that we examined showed evidence of selection," Bray says. "This supports the argument that most of the Ashkenazi-prevalent diseases are not generally being selected for, but instead are likely a result of a genetic bottleneck effect, followed by random drift."

Besides examining the genes responsible for previously identified diseases, Bray and colleagues went on to look for other regions of the Ashkenazi Jewish genome that display signs of selection, in comparison to European genomes. The two strongest differences between the Ashkenazi and European populations were on chromosome 2 and 12. A region including the lactase gene, which confers lactose tolerance, on chromosome 2 showed signs of strong selection in Europeans but not the Ashkenazi.

"A variant of the lactase gene swept through Europe at around the same time as the domestication of cattle several thousand years ago," Bray says. "This result suggests the selection preceded the European establishment of the Ashkenazi Jewish population, which is consistent with the historical record."

In addition, a region on chromosome 12 showed selection in the Ashkenazi Jewish population but not Europeans. This area encompasses 18 genes but the investigators noticed that one of these, ALDH2, is important in alcohol metabolism, and genetic variation in ALDH2 has previously been shown to affect alcohol consumption, Bray says.

"This is consistent with historical and modern reports of lower alcoholism rates in Jews, although social and religious practices are also thought to play a role," he says. "However, a more detailed analysis of variants in the ALDH2 gene would be necessary to show a mechanistic link."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New analysis weighs lost trade, costs to control invasive species against economic damages
2. Faster DNA analysis at room temperature
3. Analysis: July was cool this year
4. HPC for phylogenetics tutorial aims to reduce analysis time
5. Scientific expertise lacking among doubters of climate change, says Stanford-led analysis
6. Analysis of atmosphere in Phoenix, Ariz., suggests new model for sound urban growth policies
7. Major magnet grant to advance state-of-the-art in chemical analysis
8. Precise trace gas analysis, without the noise
9. Vicor Technologies announces results of PD2i analysis of MUSIC trial data
10. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
11. DNA analysis suggests whale meat from sushi restaurants in L.A., Seoul originated from Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... 9, 2009 -- Gregg Duester, Ph.D., professor of developmental ... with Xianling Zhao, Ph.D., and colleagues, have clarified the ... The study showed that retinoic acid controls the development ... retinoic acid is not responsible for patterning (or differentiation ...
... trials show that a new colon cancer screening technique ... sensitivity that it could potentially be as or more ... The technique uses optical technology, called low-coherence enhanced ... the base of the rectum. Light shines on the ...
... Adaptation Flagship and University of Queensland scientist, Dr ... joyride, is associated with over-fishing and excess nutrients ... aggregations can be a natural feature of healthy ... emerging of more severe and frequent jellyfish outbreaks ...
Cached Biology News:Embryology study offers clues to birth defects 2Colon cancer screening technique shows continued promise in new study 2'Jellyfish joyride' a threat to the oceans 2
(Date:8/27/2015)... , Aug. 27, 2015  Neogen Corporation (NASDAQ: ... stock of United Kingdom -based Lab ... culture media and diagnostic systems. Lab ... a leading provider of microbial testing and diagnostic products ... markets. The company currently sells into more than 70 ...
(Date:8/27/2015)... Calif. , Aug. 27, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... conferences in the month of September.  ... present at Rodman & Renshaw,s 17th Annual Global Investment ... PT at the St. Regis Hotel in ...
(Date:8/27/2015)... GlassesOff (OTCBB: GLSO), a visual neuroscience ... human vision system, announced today a partnership with eight-time All-Star, ... Paul to develop a new mobile app designed for ... real-life on-court performance. Vision is the inception of ... a ball or blocking a pass. The critical impact vision ...
(Date:8/27/2015)... PARK, N.C. , Aug. 27, 2015 /PRNewswire/ ... the decision by FedEx, UPS and The US ... certain biological specimens classified as ,select agents, by ... long history of handling these sensitive shipments. ... of global transportation regulations, trained and certified personnel ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... ... and hybridoma productivity. , ... Fort Collins, CO (PRWEB) March 3, 2010 -- InVitria’s launch ... created to improve monoclonal antibody productivity and deliver easier purification of the target ...
... , ... ... ... ...
... , ... ... ... ...
Cached Biology Technology:InVitria Optimizes Hybridoma Cell Culture with New Product Zap-Hybridoma 2InVitria Optimizes Hybridoma Cell Culture with New Product Zap-Hybridoma 3China Medical Technologies Reports Third Fiscal Quarter Financial Results 2China Medical Technologies Reports Third Fiscal Quarter Financial Results 3China Medical Technologies Reports Third Fiscal Quarter Financial Results 4China Medical Technologies Reports Third Fiscal Quarter Financial Results 5China Medical Technologies Reports Third Fiscal Quarter Financial Results 6China Medical Technologies Reports Third Fiscal Quarter Financial Results 7China Medical Technologies Reports Third Fiscal Quarter Financial Results 8China Medical Technologies Reports Third Fiscal Quarter Financial Results 9China Medical Technologies Reports Third Fiscal Quarter Financial Results 10China Medical Technologies Reports Third Fiscal Quarter Financial Results 11China Medical Technologies Reports Third Fiscal Quarter Financial Results 12China Medical Technologies Reports Third Fiscal Quarter Financial Results 13China Medical Technologies Reports Third Fiscal Quarter Financial Results 14China Medical Technologies Reports Third Fiscal Quarter Financial Results 15China Medical Technologies Reports Third Fiscal Quarter Financial Results 16China Medical Technologies Reports Third Fiscal Quarter Financial Results 17China Medical Technologies Reports Third Fiscal Quarter Financial Results 18China Medical Technologies Reports Third Fiscal Quarter Financial Results 19China Medical Technologies Reports Third Fiscal Quarter Financial Results 20China Medical Technologies Reports Third Fiscal Quarter Financial Results 21China Medical Technologies Reports Third Fiscal Quarter Financial Results 22Medivation to Host Conference Call at 8:30 a.m. Eastern Time Tomorrow to Discuss Phase 3 Trial Results for Dimebon in Alzheimer's Disease 2Medivation to Host Conference Call at 8:30 a.m. Eastern Time Tomorrow to Discuss Phase 3 Trial Results for Dimebon in Alzheimer's Disease 3
... description: The "egg crate" style strip holder ... flat bottom strips. Linkage: This CLS number ... easily match Cornings product number. If showing ... old Sigma-Aldrich number (Z71,456-9) or contact customer ...
... This reagent is intended for use as ... MTF). Michels Transport Fluid is useful for ... lymph nodes) for immunofluorescence studies. Samples may ... days at room temperature. Michels Transport Fluid ...
... or 384-well PCR plates Dimples on both sides ... plates End tabs on Thermo-Mat™ 384 fit into ... sealing is achieved with either Thermo-Mat™ 96 or 384 ... lid thermal cyclers Fully autoclavable May ...
... The TUNEL-based assay kit provides complete components ... convenient detection of DNA fragmentation in cultured ... BrdU in the procedure provides greater sensitivity ... be analyzed by flow cytometry. The kit ...
Biology Products: