Navigation Links
Analysis of Ashkenazi Jewish genomes reveals diversity, history
Date:8/26/2010

ainst malaria. Some scientists have proposed that disease-related mutations have persisted in the Ashkenazi Jewish population because of a similar hidden positive effect.

"Only six of the 21 disease genes that we examined showed evidence of selection," Bray says. "This supports the argument that most of the Ashkenazi-prevalent diseases are not generally being selected for, but instead are likely a result of a genetic bottleneck effect, followed by random drift."

Besides examining the genes responsible for previously identified diseases, Bray and colleagues went on to look for other regions of the Ashkenazi Jewish genome that display signs of selection, in comparison to European genomes. The two strongest differences between the Ashkenazi and European populations were on chromosome 2 and 12. A region including the lactase gene, which confers lactose tolerance, on chromosome 2 showed signs of strong selection in Europeans but not the Ashkenazi.

"A variant of the lactase gene swept through Europe at around the same time as the domestication of cattle several thousand years ago," Bray says. "This result suggests the selection preceded the European establishment of the Ashkenazi Jewish population, which is consistent with the historical record."

In addition, a region on chromosome 12 showed selection in the Ashkenazi Jewish population but not Europeans. This area encompasses 18 genes but the investigators noticed that one of these, ALDH2, is important in alcohol metabolism, and genetic variation in ALDH2 has previously been shown to affect alcohol consumption, Bray says.

"This is consistent with historical and modern reports of lower alcoholism rates in Jews, although social and religious practices are also thought to play a role," he says. "However, a more detailed analysis of variants in the ALDH2 gene would be necessary to show a mechanistic link."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New analysis weighs lost trade, costs to control invasive species against economic damages
2. Faster DNA analysis at room temperature
3. Analysis: July was cool this year
4. HPC for phylogenetics tutorial aims to reduce analysis time
5. Scientific expertise lacking among doubters of climate change, says Stanford-led analysis
6. Analysis of atmosphere in Phoenix, Ariz., suggests new model for sound urban growth policies
7. Major magnet grant to advance state-of-the-art in chemical analysis
8. Precise trace gas analysis, without the noise
9. Vicor Technologies announces results of PD2i analysis of MUSIC trial data
10. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
11. DNA analysis suggests whale meat from sushi restaurants in L.A., Seoul originated from Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
(Date:11/18/2014)... 2014   News Highlights: ... develop The Partners Data Lake, an agile data ... Lake will allow researcher and clinicians to explore ... the lives of patients , The Partners ... across the Partners system, breaking down physical barriers ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock ... authentication solutions, and MorphoTrust USA (Safran), ... services, today announced a strategic partnership to offer ... motor vehicle administration (MVA), airport screening and financial ... identity-related solutions, MorphoTrust serves consumers through a nationwide ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... indicates that wild salmon may account for just 10 ... vast majority of the fish come from hatcheries. The ... decline in the population this year, which will probably ... and recreational salmon fishing. The role of ...
... 15 years of biodiversity and climate change research ... announced formation of its Asia Center to forge ... use of environmental resources. One of the first ... Philadelphia, is with Nanjing University, one of the ...
... Inzana, the Tyler J. and Frances F. Young Professor ... Pathobiology in the Virginia-Maryland Regional College of Veterinary Medicine ... the United States Department of Agriculture to study the ... Disease Complex (BRDC). The $374,000 grant will allow ...
Cached Biology News:Hatchery fish outnumber wild chinook salmon in troubled fall run 2Hatchery fish outnumber wild chinook salmon in troubled fall run 3Hatchery fish outnumber wild chinook salmon in troubled fall run 4Hatchery fish outnumber wild chinook salmon in troubled fall run 5Academy establishes Asia Center to protect the environment 2Academy establishes Asia Center to protect the environment 3Academy establishes Asia Center to protect the environment 4Veterinary college researchers explore function of biofilm in bovine respiratory disease 2
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
(Date:11/22/2014)... 2014 Two new educational webinars hosted by ... for ALS research and how the pharmaceutical industry can make ... Bucket Challenge: Where Does the ALS Money Go? , Featuring ... 2014, Time: 1:30pm ET, Register to attend , ... Merit Cudkowicz, Julianne Dorn Professor of Neurology at Massachusetts General ...
(Date:11/22/2014)... Prominent academics, leaders of the ... December 3rd at Genetic Rx, a networking conference ... take place at the Joseph B. Martin Conference ... the present and future of genetic medicines—including siRNA, ... editing—as well as the treatment of patients with ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
Breaking Biology Technology:Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2RURO Announces Limfinity® version 5.1.4 2
... Building upon a series of successful preclinical studies, researchers ... today announced the beginning of a Phase 1 clinical trial, ... they developed that can neutralize the Hepatitis C virus (HCV). ... as MBL-HCV1 on July 28, 2009, and the study is ...
... ... a new lab?,Now is the perfect time to choose new laboratory equipment.,NuAire, a world leader ... option. To learn more, visit www.nuaire.com/ecopackage . , ... Plymouth, MN (PRWEB) August 14, 2009 -- With such a ...
... N.J., Aug. 14 DOR BioPharma, Inc. (OTC Bulletin Board: DORB) ... financial results for the second quarter of 2009. , ... National Institutes of Health (NIH) grants, for the second quarter of ... second quarter of 2008. Revenues for the first half of ...
Cached Biology Technology:First human gets new antibody aimed at hepatitis C virus 2DOR BioPharma Reports 2nd Quarter and 1st Half 2009 Financial Results and Reviews Recent Accomplishments 2DOR BioPharma Reports 2nd Quarter and 1st Half 2009 Financial Results and Reviews Recent Accomplishments 3DOR BioPharma Reports 2nd Quarter and 1st Half 2009 Financial Results and Reviews Recent Accomplishments 4DOR BioPharma Reports 2nd Quarter and 1st Half 2009 Financial Results and Reviews Recent Accomplishments 5
Rabbit polyclonal to KIAA1276 ( Abpromise for all tested applications). entrezGeneID: 27146 SwissProtID: Q9ULE4...
...
Complement C1q subcomponent subunit C precursor. [Source:Uniprot/SWISSPROT;Acc:P02747] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
3M Imidazole Solution 125 ml...
Biology Products: