Navigation Links
Analysis of Ashkenazi Jewish genomes reveals diversity, history
Date:8/26/2010

ainst malaria. Some scientists have proposed that disease-related mutations have persisted in the Ashkenazi Jewish population because of a similar hidden positive effect.

"Only six of the 21 disease genes that we examined showed evidence of selection," Bray says. "This supports the argument that most of the Ashkenazi-prevalent diseases are not generally being selected for, but instead are likely a result of a genetic bottleneck effect, followed by random drift."

Besides examining the genes responsible for previously identified diseases, Bray and colleagues went on to look for other regions of the Ashkenazi Jewish genome that display signs of selection, in comparison to European genomes. The two strongest differences between the Ashkenazi and European populations were on chromosome 2 and 12. A region including the lactase gene, which confers lactose tolerance, on chromosome 2 showed signs of strong selection in Europeans but not the Ashkenazi.

"A variant of the lactase gene swept through Europe at around the same time as the domestication of cattle several thousand years ago," Bray says. "This result suggests the selection preceded the European establishment of the Ashkenazi Jewish population, which is consistent with the historical record."

In addition, a region on chromosome 12 showed selection in the Ashkenazi Jewish population but not Europeans. This area encompasses 18 genes but the investigators noticed that one of these, ALDH2, is important in alcohol metabolism, and genetic variation in ALDH2 has previously been shown to affect alcohol consumption, Bray says.

"This is consistent with historical and modern reports of lower alcoholism rates in Jews, although social and religious practices are also thought to play a role," he says. "However, a more detailed analysis of variants in the ALDH2 gene would be necessary to show a mechanistic link."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New analysis weighs lost trade, costs to control invasive species against economic damages
2. Faster DNA analysis at room temperature
3. Analysis: July was cool this year
4. HPC for phylogenetics tutorial aims to reduce analysis time
5. Scientific expertise lacking among doubters of climate change, says Stanford-led analysis
6. Analysis of atmosphere in Phoenix, Ariz., suggests new model for sound urban growth policies
7. Major magnet grant to advance state-of-the-art in chemical analysis
8. Precise trace gas analysis, without the noise
9. Vicor Technologies announces results of PD2i analysis of MUSIC trial data
10. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
11. DNA analysis suggests whale meat from sushi restaurants in L.A., Seoul originated from Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
Breaking Biology News(10 mins):NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4NYSCF scientists 1 step closer to cell therapy for multiple sclerosis patients 2
... Institutes of Health announced today that it will fund ... -- chemical modifications to genes that result from diet, ... to specific human diseases and biological processes. ... as part of the NIH Roadmap for Medical Research,s ...
... University is being honored for one of its programs ... institute,s intern program has received the roundtable group,s Most ... award, as the best pollution prevention project/program. The honor ... The award is presented based on a program,s ...
... LA JOLLA, Calif., September 15, 2009 -- Researchers ... have discovered that reactive oxygen species, such as ... in forming invadopodia, cellular protrusions implicated in cancer ... professor and director of the Tumor Microenvironment Program ...
Cached Biology News:NIH funds grantees focusing on epigenomics of human health and disease 2NIH funds grantees focusing on epigenomics of human health and disease 3NIH funds grantees focusing on epigenomics of human health and disease 4K-State Pollution Prevention Institute's intern program named best 2Reactive oxygen's role in metastasis 2
(Date:7/25/2014)... 26, 2014 "Ischemic Stroke and ... provides data on the Ischemic Stroke and Cerebral ... information and data relating to the clinical trials ... full global Ischemic Stroke Research Report 2014 at: ... of the trial numbers and their recruitment status ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
(Date:7/25/2014)... July 25, 2014 Lawrence Livermore scientists ... Thomson Reuters list of " The World's Most Influential ... of the 3,000 researchers who were identified by analyzing ... those who published the highest-impact work (2002-2012 and 2012-2013). ... on combustion modeling . , "This recognition is ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), ... , today announced that it will release its unaudited ... after market close on Thursday, August 14, 2014 EDT. The ... opening on Friday, August 15, 2014, at 8:00 a.m. EDT ... to review the Company,s financial results and provide an update ...
Breaking Biology Technology:Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... 2 According to the National Institute of Health, 40 percent ... stage of diabetic retinopathy. Diabetic retinopathy, damage to the retina ... in people with diabetes and is one of the most feared ... patients who,ve had diabetes for 10 years or more will experience ...
... , ... that a new market research report is available in ... Trends , http://www.reportlinker.com/p0164494/Chromium---Global-Market-Trends.html , Worldwide ... while growth in aerospace and industrial gas turbine markets ...
... PLYMOUTH, Mass., Dec. 1 Harvest Technologies Corp. ( ... 60-patient clinical trial conducted at Sri Ramachandra Medical Center ... treat patients with non-reconstructable Critical Limb Ischemia (CLI). Sri ... based in Chennai, India and one of the largest ...
Cached Biology Technology:Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 2Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 3Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 4Reportlinker Adds Chromium - Global Market Trends 2Reportlinker Adds Chromium - Global Market Trends 3Reportlinker Adds Chromium - Global Market Trends 4Reportlinker Adds Chromium - Global Market Trends 5Reportlinker Adds Chromium - Global Market Trends 6Reportlinker Adds Chromium - Global Market Trends 7Reportlinker Adds Chromium - Global Market Trends 8Reportlinker Adds Chromium - Global Market Trends 9Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 2Harvest Technologies Announces Trial Results in its India Study Using BMAC to Treat Patients With Non-Reconstructable Critical Limb Ischemia 3
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA ...
6X Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Ideally suited for resolving DNA and RNA 10-1000 bases especially PCR products ranging from 100-1000 bp. Gelling temp. (4%) 27C Melting temperature 65C. EEO: 0.10 Rnase/Dnase: none detected...
Biology Products: