Navigation Links
Analysis of Ashkenazi Jewish genomes reveals diversity, history
Date:8/26/2010

descendants' genomes are shuffled by recombination. Successive generations continue the shuffling process, so that the linkage between traits located near each other in the genome is gradually lost over time.

High linkage disequilibrium can come either from an isolated population (for example, an island whose residents are all descendents of shipwreck survivors) or the relatively recent mixture of separate populations. Bray and his colleagues did find evidence of elevated linkage disequilibrium in the Ashkenazi Jewish population, but were able to show that this matches signs of interbreeding or "admixture" between Middle Eastern and European populations.

The researchers were able to estimate that between 35 and 55 percent of the modern Ashkenazi genome comes from European descent.

"Our study represents the largest cohort of Ashkenazi Jews examined to date with such a high density of genetic markers, and our estimate of admixture is considerably higher than previous estimates that used the Y chromosome to calculate European admixture at between five and 23 percent," Bray says.

He adds that his group's analysis agrees with a recently published study from New York University and Albert Einstein College of Medicine, and supports estimates of a high level of European admixture, accounting for up to half of the genetic make-up of contemporary Ashkenazi.

The genomic analysis also provided information about selection pressures on mutations prevalent in the Ashkenazi Jewish population, such as those leading to conditions like Tay-Sachs disease or mutations in cancer susceptibility genes like BRCA1.

This line of research seeks the answer to the question: why doesn't a harmful mutation simply disappear from the population? A classic example of positive selection is sickle-cell anemia. Two copies of the mutation are required for the disease to occur, but when an individual has one copy of the mutation, it provides resistance ag
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New analysis weighs lost trade, costs to control invasive species against economic damages
2. Faster DNA analysis at room temperature
3. Analysis: July was cool this year
4. HPC for phylogenetics tutorial aims to reduce analysis time
5. Scientific expertise lacking among doubters of climate change, says Stanford-led analysis
6. Analysis of atmosphere in Phoenix, Ariz., suggests new model for sound urban growth policies
7. Major magnet grant to advance state-of-the-art in chemical analysis
8. Precise trace gas analysis, without the noise
9. Vicor Technologies announces results of PD2i analysis of MUSIC trial data
10. Meta-analysis: Radiotherapy variants improve survival in non-metastatic lung cancer
11. DNA analysis suggests whale meat from sushi restaurants in L.A., Seoul originated from Japan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... TRIANGLE PARK, North Carolina , 5. ... sein 35. Jahr als spezialisiertes Logistikunternehmen und ... Position als einzige klinische Logistikfirma (Clinical Logistics ... Die Kernbotschaft der neuen Kampagne lautet ... und Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces the ... as part of its 2015 marketing and branding initiatives ... new consumer website for Wocketwallet.com earlier this month. ... said, "Our new corporate website naturally showcases our premiere ...
(Date:2/5/2015)... OXFORD, Conn. , Jan. 28, 2015 ... ("NXT-ID" or the "Company"), a biometric authentication company focused ... present at the upcoming RedChip Global Online CEO Conference ... Gino Pereira , CEO of ... discussing its lead product, the Wocket smart wallet and ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3
... Bethesda, MD FASEB MARC (Minority Access to Research ... the 2010 Societ Italiana di Patologia (SIP) XXX National ... These awards are meant to promote the entry of ... of the basic science community and to encourage the ...
... PITTSBURGH, Sept. 20 A structural molecule and the cellular ... and could provide new ways of treating the lung infection, ... to scientists at the University of Pittsburgh and the University ... Medicine . Despite decades of research, there has ...
... Inc. (Nasdaq: AWRE ), a global provider ... will introduce and demonstrate several new biometrics software products ... Conference and Technology Expo. The event takes place in ... to be demonstrated include Forensic Workbench, FormScanner, and BioSP™ ...
Cached Biology News:Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse 2Aware to Introduce Several New Software Products at the Biometrics Consortium Conference 2Aware to Introduce Several New Software Products at the Biometrics Consortium Conference 3Aware to Introduce Several New Software Products at the Biometrics Consortium Conference 4
(Date:2/28/2015)... February 28, 2015 Increasing its efforts to ... launches its first three episodes of The GMO TRUTH podcast ... this month, as it continues its mission to discover the ... project's first phase, to “uncover the truth about the GMOs ... , The GMO Truth Podcast is an expansion of the ...
(Date:2/27/2015)... Immunovaccine Inc. (“Immunovaccine” or the “Company”) ... press release disseminated this morning by PR Web, and ... press release states that Immunovaccine has entered into a ... release did not originate from Immunovaccine and there is ... release. Please note that all official statements by ...
(Date:2/27/2015)... Md. and SUMMERLAND, British Columbia ... (NYSE: XON ), a leader in ... agreement to acquire  Okanagan Specialty Fruits (OSF), the ... apple , the world,s first non-browning apple. Through the ... yielding fruit that is more appetizing and convenient for ...
(Date:2/27/2015)... 2015  Pharmacyclics, Inc. (NASDAQ: PCYC ... its newly developed Bruton,s tyrosine kinase (BTK) inhibitor ... The results of these preclinical evaluations have been ... The feedback received from the Agency is supportive ... Additional preclinical work is required to begin a ...
Breaking Biology Technology:The Walk a Mile Project Launches “GMO Truth” Podcast 2Immunovaccine Disclaims Hoax Press Release 2Intrexon to Acquire Okanagan Specialty Fruits 2Intrexon to Acquire Okanagan Specialty Fruits 3Intrexon to Acquire Okanagan Specialty Fruits 4Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
... in the U.S. and ... in Key Global Markets, ... JERUSALEM and MONTVALE, N.J., July 18 Teva,Pharmaceutical Industries Ltd. ... announced today that they have signed a definitive,agreement under which Teva ...
... Md., July 18 Northwest,Biotherapeutics, Inc. (AIM: NWBS ... NWBT"), today announced that Dr. Alton L. Boynton, ... presentation updating,the Company,s progress in the development of ... "Next Generation Vaccines" conference. The,conference will be held ...
... -- The Defense Advanced Research Projects Agency (DARPA) has ... of Harvard University researchers to study surface enhanced Raman ... three-year effort. , If all phases of the development ... of up to $2.9 million in funding. , Ken ...
Cached Biology Technology:Teva to Acquire Barr 2Teva to Acquire Barr 3Teva to Acquire Barr 4Teva to Acquire Barr 5Teva to Acquire Barr 6Teva to Acquire Barr 7Teva to Acquire Barr 8Northwest Biotherapeutics to Present at Next Generation Vaccine Conference 2DARPA awards research team $1.2M grant to study surface enhanced Raman scattering 2
...
Mouse monoclonal [2G1] to Vancomycin ( Abpromise for all tested applications)....
Rab1A...
... polyclonal to LYZL6 ( Abpromise ... Antigen: Synthetic peptide: DWLCL ... , corresponding to amino acids 46-100 ... Entrez Gene ID: 57151 ...
Biology Products: