Navigation Links
Anakinra for rheumatoid arthritis: A modest benefit with some risk
Date:1/20/2009

New research supports a modest beneficial effect of anakinra for rheumatoid arthritis patients, but warns against potential risks for serious infections and its use with other biologic medications.

Rheumatoid arthritis is a chronic inflammatory disease affecting as many as one in 100 people worldwide. It affects the joints, making them stiff and painful. Anakinra is one of a new breed of arthritis drugs licensed in the past decade called 'biologics'. The drug is the first to target the immune protein IL-1, thought to be partly responsible for inflammation in arthritis patients. It is given by daily injection.

In a Cochrane Systematic Review of five recent anakinra trials involving 2,876 patients, researchers found anakinra reduced pain and stiffness in patients, and helped to improve joint function, when compared to placebo. However, while around a quarter of patients experienced improvement in their symptoms as a result of taking anakinra, the researchers say the improvements are notably less than those seen with other biologics.

In addition, there were more injection site reactions with the use of anakinra and the rate of serious infections with anakinra was approaching statistical significance when compared to placebo. "We would recommend caution with the use of anakinra for rheumatoid arthritis, especially with the only modest beneficial outcomes compared to other biologic medications studied for rheumatoid arthritis," said lead researcher Dr. Marty Mertens of the University of Minnesota in the US.

One study included in the review investigated the combination of anakinra with another biologic medication, etanercept. This found no benefits in arthritis outcomes, but did show a significant increase in the number of serious adverse events. "On the basis of these results, we recommend that doctors avoid combining biologic medications with anakinra when treating patients with rheumatoid arthritis,' said Mertens.

<
'/>"/>
Contact: Jennifer Beal
wbnewseurope@wiley.com
44-012-437-70633
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies genetic risk factor for rheumatoid arthritis, lupus
2. New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
3. Blood clotting protein linked to rheumatoid arthritis
4. Electronic switch opens doors in rheumatoid joints
5. New guidelines for treating rheumatoid arthritis
6. New therapeutic target identified for rheumatoid arthritis
7. Anything but modest: The mouse continues to contribute to humankind
8. Modest CO2 cutbacks may be too little, too late for coral reefs
9. Tufts University biologists link Huntingtons disease to health benefits in young
10. The benefits of 80 million years without sex
11. New data shows benefits of MitraClip for patients with mitral regurgitation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... July 30, 2014 ResearchMoz ... Government Biometric Systems Market 2014-2024   Business Strategies, Industry ... Biometric Systems Market 2014-2024" offers the reader detailed ... the next ten years, alongside potential market opportunities ... forecasts. To view the table of ...
(Date:7/30/2014)... , July 30, 2014 NexID ... and liveness detection solutions for the biometric authentication ... industry consortium revolutionizing online authentication with standards for ... Cornett , "The decision to join FIDO Alliance ... authentication pervasive in use. We believe the FIDO ...
(Date:7/30/2014)... ranges and a changing climate threaten some of ... and so conservationists establish seed collections to save ... hopes of preserving some genetic diversity., For decades, ... models that offer a one-size-fits-all approach for how ... 50 seed samples regardless of species, pollination mode, ...
Breaking Biology News(10 mins):Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10NexID Biometrics Joins the FIDO Alliance 2Saving seeds the right way can save the world's plants 2
... The treatment of central nervous system (CNS) diseases can ... as recombinant proteins and gene medicines are not easily transported ... to "open the door" of the blood brain barrier. However, ... therapeutics to reach diseased tissue without damaging normal brain tissue ...
... , We,ve all heard examples of animal altruism: Dogs caring ... mates to the surface. Now, a study led by the ... The researchers looked at corn, in which each fertilized ... bit of tissue known as endosperm that feeds the embryo ...
... FAIRFAX, Va.The Society of Interventional Radiology and Society for ... prospective study to evaluate the use of inferior vena ... The studyalong with the formation of the IVC Filter ... August 2010 FDA medical alert detailing the possibility that ...
Cached Biology News:Propping open the door to the blood brain barrier 2Can plants be altruistic? You bet, says new CU-Boulder-led study 2Can plants be altruistic? You bet, says new CU-Boulder-led study 3Medical societies to launch large-scale study on vein filter use 2
(Date:7/29/2014)... (PRWEB) July 30, 2014 ... and collaboration company, is proud to announce the ... management positions in their Boston, Charleston and Atlanta ... to the increased demand for hosted solutions, collaboration ... efficiency and reduce cost. , SoundConnect was founded ...
(Date:7/29/2014)... technologists have hurdled a number of significant technological ... revolutionary observing technology originally created for the James ... Principal Investigator Harvey Moseley, a scientist at NASA,s ... demonstrated that electrostatically actuated microshutter arrays that ... are as functional as the current technology,s ...
(Date:7/29/2014)... SAN DIEGO , July 29, 2014   ... life sciences company that provides innovative genetic analysis solutions, ... provider of esoteric laboratory services in the ... for noninvasive prenatal testing patents and applications. ... research, innovation, and patient care, and we welcome the ...
(Date:7/29/2014)... separated from its properties? On July 29, the prestigious ... the first Cheshire Cat experiment, separating a neutron from ... CA, and Vienna University of Technology. , Chesire Cat"Well! ... Alice in Wonderland, "but a grin without a cat! ... my life!" Alice,s surprise stems from her experience that ...
Breaking Biology Technology:SoundConnect Organization and Culture is Evolving 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4
... ... ... September 3, 2009 -- Researchers at the U.S. Department of Energy,s Argonne National ... technique could lead to better biosensors, disease therapeutics and diagnostic reagents and non-laboratory ...
... , NEW YORK, Sept. 3 Reportlinker.com announces that ... , Proteomics: Technologies and Global Markets ... , , REPORT HIGHLIGHTS , ... increase from $6.7 billion in 2008 to an estimated $7.9 billion in ...
... , EMERYVILLE, Calif., Sept. 3 Adamas Pharmaceuticals, ... data will be delivered as an oral presentation during the ... in San Francisco, CA on September 13, 2009. The presentation ... study of Adamas, triple combination antiviral drug (TCAD) therapy. ...
Cached Biology Technology:Argonne Researchers Develop Method that Aims to Stabilize Antibodies 2Argonne Researchers Develop Method that Aims to Stabilize Antibodies 3Argonne Researchers Develop Method that Aims to Stabilize Antibodies 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 2Reportlinker Adds Proteomics: Technologies and Global Markets Report 3Reportlinker Adds Proteomics: Technologies and Global Markets Report 4Reportlinker Adds Proteomics: Technologies and Global Markets Report 5Reportlinker Adds Proteomics: Technologies and Global Markets Report 6Reportlinker Adds Proteomics: Technologies and Global Markets Report 7Reportlinker Adds Proteomics: Technologies and Global Markets Report 8Reportlinker Adds Proteomics: Technologies and Global Markets Report 9Reportlinker Adds Proteomics: Technologies and Global Markets Report 10Reportlinker Adds Proteomics: Technologies and Global Markets Report 11Reportlinker Adds Proteomics: Technologies and Global Markets Report 12Reportlinker Adds Proteomics: Technologies and Global Markets Report 13Reportlinker Adds Proteomics: Technologies and Global Markets Report 14Reportlinker Adds Proteomics: Technologies and Global Markets Report 15Reportlinker Adds Proteomics: Technologies and Global Markets Report 16Reportlinker Adds Proteomics: Technologies and Global Markets Report 17Reportlinker Adds Proteomics: Technologies and Global Markets Report 18Reportlinker Adds Proteomics: Technologies and Global Markets Report 19Reportlinker Adds Proteomics: Technologies and Global Markets Report 20Reportlinker Adds Proteomics: Technologies and Global Markets Report 21Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2
... Highly-purified, endotoxin-free plasmid DNA preparations are ... in quantities from 1mg to multi-gram ... as large-scale (100mg-multi-gram) preparations are made ... preparation is formulated according to customer ...
... are polypeptide hormones which belong to ... The TGF- superfamily is a large ... control many aspects of development, reproductive ... members incude TGF-s, bone morphogenetic proteins, ...
... need to be able to handle larger sample ... as well as interface with telemetry systems. ... particularly with dogs, pigs, and primates. The ... time, and the computer can be located outside ...
The new Silencer siRNA Starter Kit is perfect for researchers new to RNAi. It provides all of the reagents, protocols, and instructions necessary to get underway with siRNA transfection and ensure su...
Biology Products: