Navigation Links
An unexpected player in a cancer defense system
Date:11/28/2011

Researchers of the Swedish medical university Karolinska Institutet and the University of Cologne, Germany, have identified a new protein involved in a defense mechanism against cancer. The VCP/p97 complex is best known for its role in protein destruction and is involved in a type of familial dementia and ALS. In a novel study the researchers now describe how this complex also plays an important role in regulating the recruitment of the tumor suppressor protein 53BP1 to damaged DNA suggesting an important role for VCP/p97 in our body's defense against cancer.

Damage of DNA is potentially very dangerous and linked to the development of cancer. Since DNA damage is unavoidable, our cells are equipped with a sophisticated defense system that activates repair mechanisms. This process is initiated by binding of sensor proteins to the damaged DNA that in turn bind and activate other proteins responsible for repairing the damage. During the last decade, it has become clear how many of those proteins are recruited to the damaged DNA, but the mechanism by which the tumor suppressor 53BP1 finds its way has been puzzling.

The surprising finding of this study, presented in the scientific journal Nature Structural & Molecular Biology, is not only the identity of the new player but also how it is doing the job. By following proteins in cells with DNA damage, the researchers found that the VCP/p97 complex is among the proteins that are being recruited to DNA damage. This was unanticipated since VCP/p97 is known to be primarily involved in the destruction of defective proteins. VCP/p97 is doing this by unwinding them so that the waste proteins can be chopped in pieces by dedicated enzymes. This important function also explains its involvement in a type of familial dementia and ALS since this kind of waste proteins typically pile up in these diseases.

It turns out that VCP/p97 is doing something similar at damaged DNA although with a very diff
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study of placenta unexpectedly leads to cancer gene
2. Unexpected finding opens up new way to stop autoimmune diseases and transplant rejection
3. New and unexpected mechanism identified how the brain responds to stress
4. Red pandas reveal an unexpected (artificial) sweet tooth
5. Yeast missing sex genes undergo unexpected sexual reproduction
6. Salt block unexpectedly stretches in Sandia experiments
7. 1-finger exercise reveals unexpected limits to dexterity
8. New study reveals unexpected relationship between climate warming and advancing treelines
9. Study points to new uses, unexpected side effects of already existing drugs
10. Research reveals lipids unexpected role in triggering death of brain cells
11. Study reveals H1N1 unexpected weakness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... nucleotidethe basic building block of DNAcould initiate fragile X syndrome, the ... The Journal of Cell Biology . ... gene on the X chromosome called fragile X mental retardation ... 360 men carry a so-called premutation, in which a series of ... is slightly longer than normal. These repeats are prone to even ...
(Date:9/1/2014)... electron microscopy revealed the presence of tiny blob-like structures ... scientists still don,t know what they do even ... to be crucial to the life of a cell, ... treatment., In the Journal of Cell Biology , ... various backgrounds, from biophysics to cell biology, to focus ...
(Date:9/1/2014)... nocturnal animals, bats are perfectly adapted to a life without ... the reflected echoes to measure distance to obstacles or prey. ... echo delays. A study carried out by researchers at Technische ... this map dynamically adapts to external factors. , ... flies in too close to an object, the number of ...
Breaking Biology News(10 mins):A nucleotide change could initiate fragile X syndrome 2Scientists call for investigation of mysterious cloud-like collections in cells 2Zooming in for a safe flight 2
... PITTSBURGH, Jan. 3 Mice bred to age too quickly ... scientists at the University of Pittsburgh School of Medicine injected ... of young, healthy animals. Instead of becoming infirm and dying ... cells improved their health and lived two to three times ...
... line of attack against pancreatitis and pancreatic cancer is ... substantial new funding from the Medical Research Council (MRC). ... digestion turn on the pancreas itself. Chronic pancreatitis increases ... five-year survival rate of all common cancers in the ...
... kind, researchers at Queens College and Mount Sinai School ... and maternal gestational diabetes together may cause a 14-fold ... six year olds. The data are published in the ... Adolescent Medicine , one of the JAMA/Archives journals. ...
Cached Biology News:Pitt: A shot of young stem cells made rapidly aging mice live longer and healthier 2New stage in fighting pancreatic cancer 2Gestational diabetes and low socioeconomic status raise risk of ADHD in children 2
(Date:9/1/2014)... NewYork (PRWEB) September 01, 2014 ... Biotech and Diagnostics report provides comprehensive understanding and ... agreements entered into by the worlds leading life ... understand and analysis of how and why companies ... of a prospective partner’s negotiated deals terms provides ...
(Date:8/31/2014)... Wockhardt Limited today announces a major boost ... when two of its drugs, WCK 771 and WCK ... status from U.S. Food & Drug Administration (FDA).  QIDP ... which have a high degree of unmet need in ... Control (a top U.S. government health and safety body). ...
(Date:8/31/2014)... Available spectra is similar for all ... cultivation of a wide range of plants. The ... proven patented and pending wide spectrum technology. The ... critical applications in contrast to growth spectra made ... have a large variety of differently sized and ...
(Date:8/31/2014)... 2014 Market Research Report ... and in-depth research report on the Polyacrylamide ... including Polyacrylamide definition, classification, application, and industry ... This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic ...
Breaking Biology Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3
... Corporation,(NYSE: WAT ) today published a ... in,infant formula and liquid milk as outlined ... Technology (M.O.S.T.). The new method uses,Waters(R) ACQUITY(R) ... spectrometry (UPLC/MS/MS) operated in Multiple Reaction,Monitoring (MRM) ...
... Institutes of Health (NIH) have demonstrated for the first ... to muscles can restore voluntary movement in monkeys whose ... have promising implications for the quarter of a million ... others with paralyzing neurological diseases, although clinical applications are ...
... Researchers have created a new material that overcomes two ... all the energy contained in sunlight, and generates electrons ... , Ohio State University chemists and their colleagues ... titanium to create the hybrid material. , "There are ...
Cached Biology Technology:Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in Support of China's Ministry of Science and Technology 2Scientists restore movement to paralyzed limbs through artificial brain-muscle connections 2Scientists restore movement to paralyzed limbs through artificial brain-muscle connections 3New solar energy material captures every color of the rainbow 2
Mouse monoclonal [050-04] to C2 ( Abpromise for all tested applications). entrezGeneID: 717 SwissProtID: P06681...
Rabbit polyclonal to Bag5 ( Abpromise for all tested applications). entrezGeneID: 9529 SwissProtID: Q9UL15...
Rabbit polyclonal to Tryptophanyl tRNA synthetase ( Abpromise for all tested applications). Antigen: Recombinant full length protein (Human): Tryptophanyl tRNA synthetase Entrez Gene ID: 745...
WTAP Antibody...
Biology Products: