Navigation Links
An inventive new way to profile immune cells in blood
Date:3/5/2014

cy performed at par in a direct comparison with three "gold standard" methods: "manual five-part differential," "CBC with automated five-part differential," and "fluorescence activated cell sorting."

In further experiments they showed that their technique works to detect the mixtures of immune cells associated with known diseases and that the technique works with blood exposed to storage conditions such as freezing and the addition of anticoagulants.

Moreover, in their experiments the team showed that to distinguish among and count those various immune cell types, they only needed to measure a few dozen methylation marks in the DNA. What's sufficient to constitute a signature, in other words, can be quite short.

The main ingredients of the method, Kelsey said, are libraries of methylation signatures of cells. Kelsey's lab determined the ones needed for this study, but big new epigenetics research consortia in Europe and the United States are poised to produce many more, greatly expanding the versatility of the proprietary method to cover more immune cells and other cell types as well.

In addition to the algorithms and the libraries, the test also requires some hardware, such as commercially available methylation microarrays.

The method has proven feasible enough that many other epidemiology research labs are already using it, Kelsey said. Brown University has also applied for a patent on the technique. He said it has the potential to be cheaper and faster than current techniques, although he didn't measure that in the paper.


'/>"/>
Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Inspired: Canada funds 68 bold, inventive ways to improve health, save lives in developing countries
2. Gastric bypass surgery alters gut microbiota profile along the intestine
3. Scientists learn how pathogens hack our immune systems to go undetected
4. Study in mice raises question: Could PTSD involve immune response to stress?
5. Vitamin A used in acne medicines may help autoimmune and transplant patients
6. Puzzling question in bacterial immune system answered
7. Immune system development linked to leukemia
8. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
9. Study: Moderate alcohol consumption boosts bodys immune system
10. Peripheral immune system may regulate vulnerability to depression
11. New insights into the immune system of the gastrointestinal tract
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
An inventive new way to profile immune cells in blood
(Date:10/16/2014)... Cancer constantly wages war on the human body. ... a stalemate. In pancreatic cancer, this stalemate—known as ... becoming aggressively malignant, a phenomena that is poorly ... in the laboratory of Salvatore Torquato, a Professor ... the conditions surrounding tumor dormancy and the switch ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
(Date:10/16/2014)... (October 16, 2014) – Post-menopausal women experienced improvements ... hormone levels or genital bleeding, after 12 weeks ... investigational fermented soy germ-based nutritional supplement previously shown ... a new peer-reviewed pilot study reported in a ... annual scientific meeting. , "These data documented ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... humans to plants to the lowliest bacterium use molecules ... an organism,s development, and still others are used to ... California Institute of Technology have now found a rare ... Caenorhabditis elegans that serves a dual purpose, working ...
... L-1 Identity,Solutions, Inc., (NYSE: ID ), ... hold a supplemental conference call for Q&A with ... ended June 30,2008 financial results at 2:00 p.m. ... the initial 11:00 a.m. (ET) call,today were unable ...
... healthy, nutritious plant. The research paper, published with ... Carolina, appeared in the early online edition of the ... week of July 21. "There,s a lot of attention ... principal investigator on the study and one of the authors ...
Cached Biology News:Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes 2Caltech researchers find dual-use sexual attraction and population-control chemicals in nematodes 3L-1 Identity Solutions to Hold Supplemental Second Quarter 2008 Financial Results Q&A Conference Call at 2:00p.m. (ET) Today 2Dartmouth researchers identify an important gene for a healthy, nutritious plant 2
(Date:10/25/2014)... A new way to produce engineered skin not ... grafting technologies, it also speeds up the healing process, ... the October issue of STEM CELLS Translational Medicine, could ... result from severe burns and chronic wounds. , A ... These wounds heal by contraction, with epithelization (the process ...
(Date:10/25/2014)... LONDON , October 24, 2014 ... CytRx Corporation (NASDAQ: CYTR ), Vertex Pharmaceuticals ... (NASDAQ: ALXN ), Peregrine Pharmaceuticals Inc. (NASDAQ: ... Free research on these five companies can be accessed ... on Thursday, October 23, 2014, ended on a positive ...
(Date:10/22/2014)... and BOSTON , Oct. 22, ... a leading global specialty pharmaceutical company, and Rhythm, a ... an exclusive option to acquire Rhythm,s wholly owned subsidiary, ... peptide ghrelin agonist, for the treatment of diabetic gastroparesis ... has completed a successful Phase 2 trial of relamorelin ...
(Date:10/22/2014)... WriteResult, LLC – a premier ... working with a team of researchers from Yale University’s ... Farming Collaborative to provide electronic questionnaire data collection through ... which started in May, aims to evaluate the impact ... exposure to and participation in urban agriculture to impact ...
Breaking Biology Technology:New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 2Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 3Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 4Biotech Stocks Technical Data - CytRx, Vertex Pharma, Alexion Pharma, Peregrine Pharma, and StemCells 5Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 2Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 3Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 4Actavis Signs Option to Acquire Rhythm Subsidiary and its GI Development Product, Relamorelin 5myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... is next weekend's BarCamp Madison , but his long-view ... state's first national technology unconference. , ,Wisconsin has the honor ... 23-26 on the Jefferson County fairgrounds. , ,Rheingans, director of ... to draw 5,000 technologists to the 90-acre site, which is ...
... and the Vancouver Island Health Authority (VIHA) ... authority would purchase 48 new ultrasound systems. , ,The ... new clinical workflow and administrative processes. , ,Jac ... result in more precise diagnosis and faster exams, and reduce ...
... of articles on developing start-up companies in the technology or ... , , Madison, Wis. - Your ... workers. As discussed in the previous article, you generally must ... and Medicare taxes, and unemployment taxes on wages ...
Cached Biology Technology:Wisconsin to host technology BarCamp USA 2Wisconsin to host technology BarCamp USA 3Early Stage 7, Part I: Just what is an employee? 2Early Stage 7, Part I: Just what is an employee? 3Early Stage 7, Part I: Just what is an employee? 4Early Stage 7, Part I: Just what is an employee? 5