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An international competition reaffirms the potential of bioinformatics in the diagnosis of disease
Date:11/26/2012

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The challenge consisted of using computational methods to evaluate and verify samples from patients with psoriasis, multiple sclerosis, chronic pulmonary obstruction and lung cancer. The IRB Barcelona team's method was two-fold: first, Anaxomics Biotech provided published information on proteins involved in each of the diseases, and Dr. Aloy expanded this biological documentation with unpublished data from other molecules that are known to be involved. Second, Dr. Rossell integrated the biological information into his probability prediction tools. "It's a question of separating the wheat from the chaff: we need to identify which subgroups of the thousands of genes we are dealing with are important in order to use them in our analysis. We need to combine our knowledge taken from databases with data we get from experiments to get the best results," explains Rossell.

The first IMPROVER challenge has highlighted the predictive power of biocomputation given that the majority of participants were able to diagnose patients with at least 90% certainty, and in some cases 100%.

The organizers plan to continue the IMPROVER project for the next four years. They have already announced the second challenge, which will be launched in 2013.


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Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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