Navigation Links
An international competition reaffirms the potential of bioinformatics in the diagnosis of disease
Date:11/26/2012

The biosciences are generating enormous amounts of data at unprecedented speeds. Making sense of these data and extracting useful and reliable information from databases is an increasingly difficult and complex task. Backed by the scientific community, IBM Research y Philip Morris International (PMI) R&D launched a project called IMPROVER (Industrial Methodology for PROcess VErification in Research) in May with the aim of challenging the world's best computational researchers to demonstrate the power of their methods to exploit genomic information to extract predictive and clinical indicators that are reliable and verifiable.

The first challenge posed by IMPROVER, "Diagnosis Signature", consisted of classifying a group of patients for four diseases by using genomic data obtained from clinical samples in so-called "blind tests". The team led by IRB Barcelona and Anaxomics Biotech achieved fourth place worldwide, in the competition that saw the participation of 54 groups, mainly from Europe and the US. The project was announced in Nature Biotechnology and the results from the competition will be published in high impact journals.

According to David Rossell, head of the Biostatistics and Bioinformatics Unit at IRB Barcelona who designed the probability prediction algorithms, "this type of international challenge is very effective as a proof of concept, to demonstrate that it is possible to make predictions and to make them well, when the world's most advanced and effective techniques are used." Patrick Aloy, Group Leader at the join IRB Barcelona-BSC program in computational biology, who specializes in molecular networks in disease added: "This competition fosters the creation of a scientific body of evidence for the biomedical community, including both researchers and clinicians, that adds value to and instills confidence in biocomputational techniques and their industrial applications.

Using biological information in statistical algorithms

The challenge consisted of using computational methods to evaluate and verify samples from patients with psoriasis, multiple sclerosis, chronic pulmonary obstruction and lung cancer. The IRB Barcelona team's method was two-fold: first, Anaxomics Biotech provided published information on proteins involved in each of the diseases, and Dr. Aloy expanded this biological documentation with unpublished data from other molecules that are known to be involved. Second, Dr. Rossell integrated the biological information into his probability prediction tools. "It's a question of separating the wheat from the chaff: we need to identify which subgroups of the thousands of genes we are dealing with are important in order to use them in our analysis. We need to combine our knowledge taken from databases with data we get from experiments to get the best results," explains Rossell.

The first IMPROVER challenge has highlighted the predictive power of biocomputation given that the majority of participants were able to diagnose patients with at least 90% certainty, and in some cases 100%.

The organizers plan to continue the IMPROVER project for the next four years. They have already announced the second challenge, which will be launched in 2013.


'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Related biology news :

1. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
2. International Polar Year conference: From knowledge to action
3. Large international study finds memory in adults impacted by versions of 4 genes
4. International team uncovers new genes that shape brain size, intelligence
5. Southampton researchers lead 2 international projects to help people out of poverty
6. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
7. Washington University receives $8 million to lead international childhood malnutrition effort
8. Early Bird Discounts Available on International Healthcare and Biotechnology Conferences, Save Up To $600 with Global Information
9. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
10. OU scientists and international team deciper the genetic code of the tomato
11. Digicel Launches Worlds First Biometric Identification System For International Money Transfers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... 2017 NXT-ID, Inc. (NASDAQ:   NXTD ... the appointment of independent Directors Mr. Robin D. Richards ... of Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief ... to their guidance and benefiting from their considerable expertise as ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:9/18/2017)... , Sept. 18, 2017   Montrium , a growing leader ... exciting new partnership with a groundbreaking non-profit research organization, Multidisciplinary ... ... psychotherapy studies for PTSD ... recently granted Breakthrough Therapy Designation to MDMA for the treatment of ...
(Date:9/14/2017)... ... September 14, 2017 , ... ... pharma and biotech at the third annual DrugDev Summit, November 7-8, 2017 in ... the world’s most progressive clinical research leaders for best practice case studies, keynote ...
(Date:9/14/2017)... (PRWEB) , ... September 14, 2017 , ... AIM Global, ... Medical Tracking Systems Inc. has won the 2017 Case Study Competition for AIDC. ... which provide benefits that decrease risk” and push the adoption of automated data collection ...
(Date:9/12/2017)... Brunswick, NJ (PRWEB) , ... September 12, 2017 ... ... one of the fastest growing b2b product testing and development companies will be ... expanded service offerings. , Contract Pharma is an educational ...
Breaking Biology Technology: