Navigation Links
An important discovery related to anxiety disorders and trauma
Date:12/4/2013

st author of the study. "To monitor STFP, a demonstrator mouse, after eating a flavoured diet, was returned to its home cage to interact with its cage-mates. The cage-mates were later tested for their preference between the demonstrator and a novel-flavoured diet. Mice lacking PC7 did not seem to prefer the demonstrator diet, which is a significant indication of their reduced ability to detect and remember olfactory cues on the breath and whiskers of the demonstrator during their social interaction in the home cage."

The article published in PNAS shows that mice lacking PC7 also had lower levels of a protein called BDNF, a member of the neurotrophin family, which is composed of proteins that regulate the development, function, and survival of neurons. BDNF is active in the hippocampus and amygdala, and is important for emotional and long-term memory, as well as learning and higher thinking.

"The reduced levels of active BDNF partly explain why the mice exhibited learning and memory impairments," says Dr. Seidah. "Furthermore, when we treated mice with DHF, a chemical that binds to BDNF receptors, we found that BDNF levels were increased and behaviour was normalized," adds Dr. Wetsel.

The results of a second study, published in Nature, demonstrate that a lack of PC7 also results in an excess of dopamine in the brain. Dopamine plays important roles in motivation, cognition and reward, and the dopamine system is associated with several neurological and psychiatric conditions. In this study, bioinformatician Jrmy Besnard from the University of Dundee in the United Kingdom transformed the structure of existing pharmaceutical drugs, already proven to be safe, so they could be used to treat new diseases. He tested his new approach by modifying a drug used against Alzheimer's disease in order to block the action of dopamine in the brain.

"We tested the effects of this new drug on mice lacking PC7, and found it to be succes
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dads: How important are they?
2. Salk scientists crack riddle of important drug target
3. Protecting the weedy and wild kin of globally important crops
4. Global analysis reveals new insights into the ribosome -- with important implications for disease
5. UdeMs IRIC and IRICoR achieve important milestone in their collaboration with Bristol-Myers Squibb
6. New cell component important to tea and wine-making
7. Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
8. Goldschmidt2014 -- The worlds most important Geochemistry conference
9. New study reveals important role of insulin in making breast milk
10. Total amount of exercise important, not frequency, research shows
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... German . ... the refraction of X-rays through a specimen instead of ... method are often of much higher quality than those ... Prof. Franz Pfeiffer are particularly interested in developing new ... X-ray phase-contrast imaging. One main goal is to make ...
(Date:7/11/2014)... Shenzhen, July 10, 2014---A team of researchers from The ... have identified a gene of wild soybean linked to ... to grow in saline soil. This study published online ... to unveil novel genomic information for crop improvement. , ... to domestication and human selection, cultivated soybeans have less ...
(Date:7/11/2014)... An international team of researchers, including scientists from the ... just a reported a major step in understanding photosynthesis, ... now maintains the oxygen in its atmosphere and which ... on earth. , The researchers report the first ... reaction, namely the step in which a specific protein ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2BGI reports a novel gene for salt tolerance found in wild soybean 2A first direct glimpse of photosynthesis in action 2
... environmental engineer has received a three-year, $561,730 grant to identify ... water providers can take action to contain and curb the ... Foundation have awarded Assistant Professor Hyeok Choi the grant to ... exist so that the harmful algae can be monitored. , ...
... mouth are telling Oak Ridge National Laboratory scientists something ... code of bacteria linked to the condition. The ... of Sciences , profiles the SR1 bacteria, a group ... mouth to deep within the Earth, that have never ...
... the most widely advocated strategies for dealing with HIV/AIDS could ... of men who have sex with men (MSM) in LA ... In the United States, LA County has the largest ... and treat" policy which calls for universal testing for ...
Cached Biology News:UT Arlington engineer to search for bad algal blooms 2Human microbe study provides insight into health, disease 2Study: Widespread 'test-and-treat' HIV policies could increase dangerous drug resistance 2
(Date:7/11/2014)... 11, 2014  Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
(Date:7/10/2014)... Cleveland, Ohio (PRWEB) July 10, 2014 ... in ion channel-expressing cell lines, and the gap that ... new cells that expand its industry-leading portfolio of validated ... focuses on ion channel-expressing cell lines, as ion channels ... able to control this activity creates the potential to ...
(Date:7/10/2014)... 10, 2014 EvoDerma ’s NOOME Anti-Aging ... rejuvenating device now comes with a second treatment cup to ... , The new cup is thinner on the edges for ... target rough, thin and uneven surfaces on the face, neck ... a stimulating treatment on areas such as the cheeks and ...
(Date:7/10/2014)... July 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, ... today announced an agreement with Lineagen, Inc., ... Lineagen,s NextStep Dx PLUS.  Lineagen, focused ... neurological disorders, currently offers FirstStep Dx ... service used by healthcare providers as a ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... The Beaumont Technology,Usability Center (BTUC) will offer ... technology companies speed their product commercialization,process. ... BTUC product-usability and,human-factors experts to conduct a ... risk assessment requirements. In early 2008, the,organizations ...
... focus on Next Generation Sequence Analysis Problem -, ... Genomics Search Tool -, MISSION VIEJO, Calif., ... community for its innovative genomic search,technology, SLIM Search, ... Institute,s (CHI) Second International Next Generation,Sequencing Conference. The ...
... Calif., Sept. 26 Jazz,Pharmaceuticals, Inc. (Nasdaq: ... Executive Chairman, will provide a corporate presentation at ... NY on October 8,2007 at 8:00 a.m. Eastern ... may be accessed by visiting the,Investors section of ...
Cached Biology Technology:Beaumont Technology Usability Center To Offer Training For Medical Technology Companies 2SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 2SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 3SLIM Search, Inc. Sponsors Next Generation Sequencing Conference for the Biomedical Market 4
...
...
... System is an imaging based plate ... and high throughput screening which can ... The Hamamatsu light sources and cameras ... decades-long experience in photon detection technology. ...
... pCITE-2a-c(+) vectors are designed for enhanced translation of ... e.g. rabbit reticulocyte lysate. The maps for pCITE-2b(+) ... the following exceptions: pCITE-2b(+) is a 3793 bp ... I and Xcm I sites. Subtract 7 bp ...
Biology Products: