Navigation Links
An important discovery related to anxiety disorders and trauma
Date:12/4/2013

Montral, December 4, 2013 A team of Montral researchers at the IRCM led by Dr. Nabil G. Seidah, in collaboration with Dr. William C. Wetsel's team at Duke University in the United States, discovered that the protein PC7 plays a critical role in the brain by affecting certain types of cognitive performance such as anxiety, learning and emotional memory. Their results, recently published in the scientific journals Proceedings of the National Academy of Sciences (PNAS) and Nature, could have a significant impact on regulating behaviour related to anxiety disorders and trauma.

The scientists found that PC7, the seventh member of the proprotein convertase family responsible for converting inactive proteins into their active states, plays a critical role in specific areas of the brain such as the hippocampus and amygdala, which are important for memory and emotional reactions and are involved in anxiety responses.

"We discovered the family of proprotein convertases in my laboratory and, since 1996, we have been carefully studying its most ancient member, PC7," says Dr. Seidah, Director of the Biochemical Neuroendocrinology research unit at the IRCM. "Initially, we could not find any visible abnormalities in mice lacking this protein. Then, after four years of research on these knockout mice, we found that they had completely lost all anxiety, including the instinctive reaction that occurs in response to a perceived threat to survival."

The results of various behavioural tests in mice lacking PC7 revealed that while spatial memory remained intact, episodic and emotional memories were severely impaired. Episodic memory, the recollection of past events or experiences, can trigger a change in behaviour as a result of an event.

"We examined episodic memory with such tests as the social transmission of food preference (STFP)," explains Dr. Wetsel, Associate Professor at the Duke Institute for Brain Sciences and fir
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dads: How important are they?
2. Salk scientists crack riddle of important drug target
3. Protecting the weedy and wild kin of globally important crops
4. Global analysis reveals new insights into the ribosome -- with important implications for disease
5. UdeMs IRIC and IRICoR achieve important milestone in their collaboration with Bristol-Myers Squibb
6. New cell component important to tea and wine-making
7. Singapore scientists discover new RNA processing pathway important in human embryonic stem cells
8. Goldschmidt2014 -- The worlds most important Geochemistry conference
9. New study reveals important role of insulin in making breast milk
10. Total amount of exercise important, not frequency, research shows
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... factors, both genetic and environmental, have been blamed ... schizophrenia. Some, such as a family history of ... with Toxoplasma gondii , a parasite transmitted ... still viewed with skepticism. , A new study ... epidemiology at the University of Pennsylvania,s School of ...
(Date:10/29/2014)... all the rage. Thousands of scientists worldwide are conducting ... titanium dioxide nanoparticles from sun creams can get through ... from electronic products are as hazardous for the lungs ... food can get into the blood via the intestinal ... are flowing – and the number of scientific projects ...
(Date:10/29/2014)... in German . ... and Peter Schlögelhofer at the Max F. Perutz Laboratories ... University of Vienna dived into the process of meiosis ... display an inversion of the standard meiotic phases. The ... Nature Communications . , Meiosis is the two-step ...
Breaking Biology News(10 mins):Penn vet professor investigates parasite-schizophrenia connection 2Penn vet professor investigates parasite-schizophrenia connection 3Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3Meiotic cell division 'the other way round' 2
... Damselfish are killing head corals and adding stress ... poor condition from global climate change, coral diseases, hurricanes, ... favorite homestead, will take the pressure off the other ... online journal PLoS ONE . The small, ...
... miles of the nation,s infrastructure of water ... of its useful life, but the mostly ... attention because of this "invisibility," said Sunil ... and environmental engineering (CEE). http://www.cee.vt.edu/index.php?do=view&content=0&apps=2&level=2&id=17&pid=b024555fa7f439a27509de488a7b5749 ...
... most likely to occur on Sunday, in less than 6 ... wearing black and white bathing suits, a first of its ... analyzed statistics from shark attacks that occurred in Florida,s Volusia ... 1956 and 2008. They also spent a year observing people ...
Cached Biology News:Distressed damsels stress coral reefs 2Efforts underway at Virginia Tech to address deterioration of nation's water pipes 2Case study analyzes why, where and when of leading shark attack site 2Case study analyzes why, where and when of leading shark attack site 3
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Calif. , Oct. 30, 2014 Isis Pharmaceuticals, ... therapeutics, today announced that management will present a company overview ... at 8:30 a.m. ET in Boston, MA. ... be available on the "Investors & Media" section of the ... on the Isis website within 48 hours and will be ...
(Date:10/30/2014)... (Oct. 29, 2014) – The severe flooding that devastated ... been less destructive if the bridges, roads and other ... new study from the University of Colorado Denver. , ... infrastructure," said Jimmy Kim, PhD, associate professor of structural ... Applied Science and lead author the study. "There is ...
(Date:10/27/2014)... and TORONTO , Oct. 27, ... ) (OTCQB: GNBT) today announced two presentations demonstrating ... by its novel proprietary cancer immunotherapeutic AE37 vaccine ... cancer patients. The AE37 cancer vaccine is being ... Inc. ( www.antigenexpress.com ). The presentations are being ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2CU Denver study says upgrading infrastructure could reduce flood damage 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 2Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 3Generex Announces Presentations Correlating Immunological Response with Reduced Recurrence in Phase II Study of AE37 Breast Cancer Vaccine in Patients at the American College of Surgeons 4
... When Hurricane Dennis reached landfall in the Florida ... surprising a development. Weather Central Inc. , a ... almost the exact location two days earlier. , ,On ... a service used by more than 100 television stations ...
... unexpectedly, this sudden accident incubates a branding process, which can ... gives birth to an extreme name identity, whereupon a major ... not stirred -- and that's how we refer to today's ... the secrets of the various branding tricks and become aware ...
... by thousands of U.S. companies since the 1970s, it ... in more than 35 states have introduced legislation restricting ... effective cost-cutting tool has begun to soar. Early in ... outsourcing, it was often viewed as a way ...
Cached Biology Technology:Accidental naming 2Accidental naming 3Accidental naming 4Consider the legal issues before outsourcing offshore 2Consider the legal issues before outsourcing offshore 3Consider the legal issues before outsourcing offshore 4Consider the legal issues before outsourcing offshore 5
... Clarin represents the state-of-the-art in ... for the permanent preservation of immunohistochemical ... (DAB), Vega Red, New Fuchsin, and ... substrates on tissue sections. Clarin can ...
... Gene Inspector can perform many sophisticated DNA analysis ... much more than just another sequence analysis product. ... suite of analyses to be performed each time ... custom style sheets which specify exactly how your ...
... columns is a well-known separation technique in ... are in DNA/RNA extraction in microbiology, viral ... in chemical or analytical laboratories. ,This ... series instruments for smaller scales. The extraction ...
... is a revolutionary new application for ... a novel interface, Expression makes complex ... simple. Expression uses the very latest ... in the way sequences are analysed. ...
Biology Products: