Navigation Links
An important breakthrough in the fight against muscular dystrophies
Date:9/12/2012

An important breakthrough could help in the fight against myotonic dystrophy. The discovery, recently published in the prestigious scientific journal Cell, results from an international collaboration between researchers at the IRCM, the Massachusetts Institute of Technology (MIT), the University of Southern California and Illumina. Their findings could lead to a better understanding of the causes of this disease.

Myotonic dystrophy (DM), also known as Steinert's disease, is the most common form of muscular dystrophies seen in adults. This disorder is characterized by muscle weakness and myotonia (difficulty in relaxing muscles following contraction). It is a multi-system disease, typically involving a wide range of tissues and muscle.

"We studied a specific family of proteins called muscleblind-like proteins (Mbnl), which were first discovered in the fruit fly Drosophila melanogaster," says Dr. ric Lcuyer, Director of the RNA Biology research unit at the IRCM. "These RNA-binding proteins are known to play important functions in muscle and eye development, as well as in the pathogenesis of DM in humans."

Because of the extreme heterogeneity of clinical symptoms, DM has been described as one of the most variable and complicated disorders known in medicine. The systems affected, the severity of symptoms, and the age of onset of those symptoms greatly vary between individuals, even within the same family.

"In patients with DM, levels of Mbnl proteins are depleted to different extents in various tissues," explains Dr. Neal A.L. Cody, postdoctoral fellow in Dr. Lcuyer's laboratory. "These alterations in levels and functions of Mbnl proteins are thought to play an important role in causing the disease."

"The global transcriptome analyses conducted in this study yielded several insights into Mbnl function and established genomic resources for future functional, modeling, and clinical studies," add Drs. Christopher B.
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improved Authentication and Confidentiality Protection. ICAP Patent Brokerage Announces for Auction Important Patents in Data Encryption and Document Security
2. Misperception of weight is an important barrier to weight loss
3. Zip code as important as genetic code in childhood obesity
4. Geneticist develops tool to identify genes important in disease, tailoring individual treatment
5. Overweight? New research explains how proper sleep is important for healthy weight
6. Wildfire and an example of its important link to the ecosystem
7. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
8. Large, medically important class of proteins starts to yield its secrets
9. It must be important but what does it do? The strange case of UCP2
10. Reciprocity an important component of prosocial behavior
11. New research: Soluble corn fiber plays important role in gut health and calcium absorption
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... 2015 As the digital payment ... and advanced biometrics technology is accelerating beyond expectations.  While ... on using their credit cards, the digital currency, mobile ... payment services led by companies in the space such ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
(Date:8/11/2015)... -- Today, ZUK announced its Android smartphone Z1, featuring ... revenues in 2015 that relate to sales of FPC1155 for this ... 2,200 MSEK for 2015. Jörgen Lantto, CEO of FPC, ... smartphone manufacturer in China and we ... 155 for Z1 , ...
(Date:8/6/2015)... REDWOOD CITY, Calif. , Aug. 6, 2015 ... (D-Silicon Valley) will visit Crossmatch ™ to ... secure networks and protect data. Crossmatch is a ... solutions whose technologies and expertise are helping federal ... operational efficiency and security.   "The ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Rep. Honda to Visit Crossmatch in Redwood City 2
... nanotechnology fanciers suggest that, like proverbial birds of ... or clump together. This tendency, they ... manufacturing increases and the number of nanotechnology-enabled products ... Maynard, chief science advisor to the Project on ...
... completing the first large-scale report sequencing breast and colon ... studied the vast majority of protein-coding genes which now ... mutated in relatively few cancers. Their report, published ... indicates that while little is known about these less-commonly ...
... a reality today, but how can we find out about ... a full record of the Earths climate for several hundred ... that can be taken to the lab for analysis. Incredibly, ... Antarctic regions, and a European Science Foundation programme has a ...
Cached Biology News:Nanoparticle exposures happen, says expert 2Genome update defines landscape of breast and colon cancers 2Genome update defines landscape of breast and colon cancers 3European lead in reading past climates from ice cores 2European lead in reading past climates from ice cores 3
(Date:8/26/2015)... Aug. 26, 2015  The Diabetes Research Institute ... of Miami Miller School of Medicine, announced today ... to test for the first time a novel ... This FDA approved Phase I/II study builds upon ... is an important first step toward the development ...
(Date:8/26/2015)... , August 26, 2015 After litigating ... Europlasma NV relating to P2i United States ... their dispute in the United States ... the part of either party. As a result of the ... of California dismissed the case without ...
(Date:8/25/2015)... ... August 25, 2015 , ... A new ... cancerous is described by University of Illinois researchers in the Journal of ... , In “ Breast cancer diagnosis using spatial light interference microscopy ,” published ...
(Date:8/25/2015)... Aug. 25, 2015  InformedDNA, a leading provider ... has been awarded Certification in Utilization Management by ... NCQA is a private, non-profit organization ... a wide range of healthcare organizations. It also ... performance. "Our achievement of the NCQA ...
Breaking Biology Technology:Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4P2i Settles United States Litigation 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 3New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 4InformedDNA Achieves NCQA Utilization Management Certification 2
... Reportlinker.com announces that a new market research ... Global D-Amino Acids Industry ... This report analyzes the worldwide markets for ... provides separate comprehensive analytics for the US, ...
... announces that a new market research report ... Global High Throughput Screening (HTS) Industry ... This report analyzes the worldwide markets ... Million. The report provides separate comprehensive analytics ...
... 8, 2011 Reportlinker.com announces that a ... its catalogue: Global Molecular ... This report analyzes the ... Million by the following technologies: Fluorescence In ...
Cached Biology Technology:Global D-Amino Acids Industry 2Global D-Amino Acids Industry 3Global D-Amino Acids Industry 4Global D-Amino Acids Industry 5Global D-Amino Acids Industry 6Global D-Amino Acids Industry 7Global D-Amino Acids Industry 8Global D-Amino Acids Industry 9Global D-Amino Acids Industry 10Global D-Amino Acids Industry 11Global D-Amino Acids Industry 12Global D-Amino Acids Industry 13Global D-Amino Acids Industry 14Global D-Amino Acids Industry 15Global D-Amino Acids Industry 16Global High Throughput Screening (HTS) Industry 2Global High Throughput Screening (HTS) Industry 3Global High Throughput Screening (HTS) Industry 4Global High Throughput Screening (HTS) Industry 5Global High Throughput Screening (HTS) Industry 6Global High Throughput Screening (HTS) Industry 7Global High Throughput Screening (HTS) Industry 8Global Molecular Cytogenetics Industry 2Global Molecular Cytogenetics Industry 3Global Molecular Cytogenetics Industry 4Global Molecular Cytogenetics Industry 5Global Molecular Cytogenetics Industry 6Global Molecular Cytogenetics Industry 7Global Molecular Cytogenetics Industry 8Global Molecular Cytogenetics Industry 9Global Molecular Cytogenetics Industry 10Global Molecular Cytogenetics Industry 11Global Molecular Cytogenetics Industry 12
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Inquire...
1M stock solution (238mg/ml)...
...
Biology Products: