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An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
Date:12/22/2010

n B-cell production, a pathogen invasion would most certainly lead to rapid death.

"The important breakthrough in this study is the discovery that the IL-7 signaling pathway uses the transcription factor Miz-1 to ensure both B-cell survival and maturation," adds Dr. Mry. "Our research project therefore confirmed the importance of this signaling pathway for the development of antibody-producing cells. Our next step will be to study the impact of Miz-1 in the development of B-cell leukemia. If this regulator is necessary for the production of B cells, it is possible that it is also required for the development of B-cell leukemia. It may thus be a target for therapeutic interventions in the treatment of this type of blood cancer."


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Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

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