Navigation Links
An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
Date:12/22/2010

A team at the Institut de recherches cliniques de Montral (IRCM) led by Dr. Tarik Mry, President and Scientific Director of the institute and Director of the Hematopoiesis and Cancer research unit, will be publishing an important breakthrough in tomorrow's issue of Immunity, a scientific journal from the Cell Press group. The researchers identified a new regulator playing a critical role in the development B cells, which produce antibodies.

Antibodies circulate through the blood and protect against infectious diseases originating from bacteria or viruses. A lack of antibodies causes the immune system to be severely compromised against infections, and is therefore life-threatening. By producing specific antibodies, mature functional B cells are essential for the body's immune response. The regulator discovered by the researchers is a transcription factor called Miz-1, which is needed for the proper development and maturation of B cells in the bone marrow. This maturation process also requires a growth factor called Interleukin-7 (IL-7) that enables the development of B cells by providing it with the necessary survival signals.

"We initially wanted to clarify the role of Miz-1 during hematopoiesis, which is the formation of all blood cellular components," explains Dr. Christian Kosan, Research Associate in Dr. Mry's research unit and the study's first author. "Surprisingly, our study demonstrated that Miz-1 is required predominantly for the very early stages of B-cell development in the bone marrow. For instance, after deleting the Miz-1 gene in a mouse, we discovered that it had almost completely lost its ability to generate B cells. "

Upon closer evaluation, the research team found that Miz-1 has a very particular function: it is required for IL-7 to effectively trigger the maturation of B cells in the bone marrow. For that reason, mice lacking the Miz-1 transcription factor were immunocompromised, and with this severe defect in B-cell production, a pathogen invasion would most certainly lead to rapid death.

"The important breakthrough in this study is the discovery that the IL-7 signaling pathway uses the transcription factor Miz-1 to ensure both B-cell survival and maturation," adds Dr. Mry. "Our research project therefore confirmed the importance of this signaling pathway for the development of antibody-producing cells. Our next step will be to study the impact of Miz-1 in the development of B-cell leukemia. If this regulator is necessary for the production of B cells, it is possible that it is also required for the development of B-cell leukemia. It may thus be a target for therapeutic interventions in the treatment of this type of blood cancer."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. Process leading to protein diversity in cells important for proper neuron firing
2. A discovery could be important for the therapy of lymphoma and leukemia
3. Is the shape of a genome as important as its content?
4. Scientists reveal important clues to how bacteria and viruses are identified as enemies
5. ‘Scientific leaders of the future’ gear up for important talks on Capitol Hill
6. U of Alberta researchers discover important mechanism in fighting infection
7. Sensor important to understanding root, seedling development
8. Important clue to understanding the pathogenesis of ciliary disorders
9. Protein important in diabetes may also play a key role in heart disease, other disorders
10. Immune system important in fight against stomach cancer
11. UD prof helps discover new chemical method important to drug design, agrichemicals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 2016   LegacyXChange, ... "Company") LegacyXChange is excited to release its ... to be launched online site for trading 100% guaranteed ... will also provide potential shareholders a sense of the ... an industry that is notorious for fraud. The video ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
(Date:3/17/2016)... ABI Research, the leader in transformative ... market will reach more than $30 billion by ... Consumer electronics, particularly smartphones, continue to boost the ... reach two billion shipments by 2021 at a ... Research Analyst at ABI Research. "Surveillance is also ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... During a ... technology into a viable company, CereScan’s CEO, John Kelley, joined other Denver business ... leader and mentor in the Denver area business community, shared his top fundamental ...
(Date:4/28/2016)... , April 28, 2016 The ... and Brayton Cryocoolers), Service (Technical Support, Product Repairs & ... - Global Forecast to 2022", published by MarketsandMarkets, the ... Billion by 2022, at a CAGR of 7.29% between ... data Tables and 94 Figures spread through 159 Pages ...
(Date:4/28/2016)... ... April 28, 2016 , ... As part of an ongoing ... and expanding its LATAM network and logistics capabilities. Enhancements have been made ... clinical trial projects. , The expansion will provide unmatched clinical trial logistics services ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased to announce ... a volunteer member of Committee since 1987. Since then, he has served in a ... and was chairman for both the program and exposition committees. In his professional career, ...
Breaking Biology Technology: