A team at the Institut de recherches cliniques de Montral (IRCM) led by Dr. Tarik Mry, President and Scientific Director of the institute and Director of the Hematopoiesis and Cancer research unit, will be publishing an important breakthrough in tomorrow's issue of Immunity, a scientific journal from the Cell Press group. The researchers identified a new regulator playing a critical role in the development B cells, which produce antibodies.
Antibodies circulate through the blood and protect against infectious diseases originating from bacteria or viruses. A lack of antibodies causes the immune system to be severely compromised against infections, and is therefore life-threatening. By producing specific antibodies, mature functional B cells are essential for the body's immune response. The regulator discovered by the researchers is a transcription factor called Miz-1, which is needed for the proper development and maturation of B cells in the bone marrow. This maturation process also requires a growth factor called Interleukin-7 (IL-7) that enables the development of B cells by providing it with the necessary survival signals.
"We initially wanted to clarify the role of Miz-1 during hematopoiesis, which is the formation of all blood cellular components," explains Dr. Christian Kosan, Research Associate in Dr. Mry's research unit and the study's first author. "Surprisingly, our study demonstrated that Miz-1 is required predominantly for the very early stages of B-cell development in the bone marrow. For instance, after deleting the Miz-1 gene in a mouse, we discovered that it had almost completely lost its ability to generate B cells. "
Upon closer evaluation, the research team found that Miz-1 has a very particular function: it is required for IL-7 to effectively trigger the maturation of B cells in the bone marrow. For that reason, mice lacking the Miz-1 transcription factor were immunocompromised, and with this severe defect i
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Institut de recherches cliniques de Montreal