Navigation Links
An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
Date:12/22/2010

A team at the Institut de recherches cliniques de Montral (IRCM) led by Dr. Tarik Mry, President and Scientific Director of the institute and Director of the Hematopoiesis and Cancer research unit, will be publishing an important breakthrough in tomorrow's issue of Immunity, a scientific journal from the Cell Press group. The researchers identified a new regulator playing a critical role in the development B cells, which produce antibodies.

Antibodies circulate through the blood and protect against infectious diseases originating from bacteria or viruses. A lack of antibodies causes the immune system to be severely compromised against infections, and is therefore life-threatening. By producing specific antibodies, mature functional B cells are essential for the body's immune response. The regulator discovered by the researchers is a transcription factor called Miz-1, which is needed for the proper development and maturation of B cells in the bone marrow. This maturation process also requires a growth factor called Interleukin-7 (IL-7) that enables the development of B cells by providing it with the necessary survival signals.

"We initially wanted to clarify the role of Miz-1 during hematopoiesis, which is the formation of all blood cellular components," explains Dr. Christian Kosan, Research Associate in Dr. Mry's research unit and the study's first author. "Surprisingly, our study demonstrated that Miz-1 is required predominantly for the very early stages of B-cell development in the bone marrow. For instance, after deleting the Miz-1 gene in a mouse, we discovered that it had almost completely lost its ability to generate B cells. "

Upon closer evaluation, the research team found that Miz-1 has a very particular function: it is required for IL-7 to effectively trigger the maturation of B cells in the bone marrow. For that reason, mice lacking the Miz-1 transcription factor were immunocompromised, and with this severe defect i
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Process leading to protein diversity in cells important for proper neuron firing
2. A discovery could be important for the therapy of lymphoma and leukemia
3. Is the shape of a genome as important as its content?
4. Scientists reveal important clues to how bacteria and viruses are identified as enemies
5. ‘Scientific leaders of the future’ gear up for important talks on Capitol Hill
6. U of Alberta researchers discover important mechanism in fighting infection
7. Sensor important to understanding root, seedling development
8. Important clue to understanding the pathogenesis of ciliary disorders
9. Protein important in diabetes may also play a key role in heart disease, other disorders
10. Immune system important in fight against stomach cancer
11. UD prof helps discover new chemical method important to drug design, agrichemicals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2015)... , Feb. 23, 2015 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... provisional patent 62114357 for DISTRIBUTED VOICE DIRECTED ... NXT-ID introduces a new groundbreaking payment method. Payment accounts ... account may only be accessed if both the speech ...
(Date:2/18/2015)... Feb. 18, 2015  Cepheid (NASDAQ: CPHD ) ... following conferences, and invited investors to participate via webcast. ... MA Tuesday, March 3, 2015 at 11.20 a.m. ... Orlando, FL Wednesday, March 4, 2015 at ... access the live webcasts for these events, please visit Cepheid,s ...
(Date:2/12/2015)...   MedNet Solutions , a global life ... systems, has recently bolstered its iMedNet™ ... iMedNet as the eClinical solution of ... consultants.  Building on the Program,s existing benefits (including ... co-marketing opportunities), MedNet,s new and improved program provides ...
Breaking Biology News(10 mins):NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3Cepheid to Webcast Upcoming Financial Presentations 2MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2
... management experts working in diverse settings in the US ... for Conservation Biology in Baltimore on Thursday July 25 ... underway, what difference such integrated management efforts are making, ... this area should be. "Ecosystem-scale restoration efforts, ...
... our close cousins, the Neandertals, were much more similar to ... have anything like modern speech and language? And if so, ... MPI for Psycholinguistics researchers Dan Dediu and Stephen C. Levinson ... that modern language and speech can be traced back ...
... the founding director of Carnegie,s Department of Global Ecology ... prizes, the Max Planck Research Prize with Markus Reichstein ... life on Earth responds to climate change and what ... atmosphere their work also helps us to estimate the ...
Cached Biology News:ICCB symposium to examine ecosystem management 2Did Neandertals have language? 2Carnegie's Chris Field receives Max Planck Research Prize 2
(Date:2/26/2015)... , Feb. 26, 2015 DuPont Executive ... priorities driven by key research advancements and product launches ... today,s Bank of America Merrill Lynch 2015 Global Agriculture ... challenge of building grain supplies the last two years, ... at the pace of the last decade, when demand ...
(Date:2/26/2015)... IRVINE, Calif. , Feb. 26, 2015 /PRNewswire/ ... of age-defying aesthetic products for skin and hair ... Market Relations as agency of record for investor ... continues to improve our distribution, sales and diversification ... activities to current and prospective shareholders," stated Ali ...
(Date:2/26/2015)... The Pittcon 2015 Exposition, which ... N. Morial Convention Center in New Orleans, Louisiana, ... 19, 2015) displaying products and services used by ... labs. The Exposition will offer the latest innovations ... analytical chemistry; drug discovery; nanotechnology; life sciences to ...
(Date:2/26/2015)... February 26, 2015 RURO, Inc., a ... FreezerPro® version 6.2 – the latest update to the ... is that of a quick and easy method to ... the latest version, RURO engineering has enhanced the system’s ... move large amounts of sample records. , "FreezerPro ...
Breaking Biology Technology:DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 2DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 3DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 4DuPont Leader Outlines Path for Growth in Agriculture and Nutrition & Health Segments 5NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3Pittcon 2015 Announces Exposition Highlights 2RURO Releases FreezerPro® version 6.2 2
... Ohio, Aug. 11 Panther Expedited Services President and ... of a new brand identity positioning Panther as a ... ground, air, ocean, and logistics services. , , ... http://www.newscom.com/cgi-bin/prnh/20090810/CL59306LOGO ) , , ...
... , , ... biotechnology company delivering breakthrough therapies in central nervous system diseases, announced ... initiative whereby each visit to www.lostandfoundcampaign.com prompts a $1 donation by ... , Every AD patient, caregiver or family who visits ...
... , , , ... ) is expanding its capabilities and services as a leading ... new professional staffing and nearly $1 million in new state-of-the-art capital ... Texcel Medical, said "medical device companies are under intense pressure to ...
Cached Biology Technology:Panther Expedited Services Unveils New Brand; Services Include Ground, Air, Ocean, & Logistics 2Accera, Inc. to Support the Alzheimer's Foundation of America's National Memory Screening Day Through On-line Awareness Effort 2Accera, Inc. to Support the Alzheimer's Foundation of America's National Memory Screening Day Through On-line Awareness Effort 3Texcel Medical Expands Medical Device Development & Manufacturing Capabilities With New Personnel, Nearly $1 Million in Capital Investments 2Texcel Medical Expands Medical Device Development & Manufacturing Capabilities With New Personnel, Nearly $1 Million in Capital Investments 3
... DNA Engine instrument is the cycler ... Unprecedented thermal uniformity and swappable blocks ... This rugged machine is ... a platform for new features and ...
Request Info...
Peroxidase Protective Buffer is a diluent formulated to stabilize the activity of Chemicon horseradish peroxidase (HRP)-antibody conjugates at high conjugate dilution for extended periods....
... (TSB), USP is a highly nutritious versatile ... use. Due to the inclusion of both ... support growth of many fastidious organisms without ... conforms to United States Pharmacopeia standards for ...
Biology Products: