Navigation Links
An equation to describe the competition between genes
Date:3/13/2014

In biology, scientists typically conduct experiments first, and then develop mathematical or computer models afterward to show how the collected data fit with theory. In his work, Rob Phillips flips that practice on its head. The Caltech biophysicist tackles questions in cellular biology as a physicist wouldby first formulating a model that can make predictions and then testing those predictions. Using this strategy, Phillips and his group have recently developed a mathematical model that accounts for the way genes compete with each other for the proteins that regulate their expression.

A paper describing the work appears in the current issue of the journal Cell. The lead authors on the paper are Robert Brewster and Franz Weinert, postdoctoral scholars in Phillips's lab.

"The thing that makes this study really interesting is that we did our calculations before we ever did any experiments," says Phillips, the Fred and Nancy Morris Professor of Biophysics and Biology at Caltech and principal investigator on the study. "Just as it is amazing that we have equations for the orbits of planets around stars, I think it's amazing that we are beginning to be able to write equations that predict the complex behaviors of a living cell."

A number of research teams are interested in modeling gene expressionaccurately describing all the processes involved in going from a gene to the protein or other product encoded by that DNA. For simplicity's sake, though, most such models do not take competition into consideration. Instead, they assume that each gene has plenty of whatever it needs in order to be expressedincluding the regulatory proteins called transcription factors. However, Phillips points out, there often is not enough transcription factor around to regulate all of the genes in a cell. For one thing, multiple copies of a gene can exist within the same cell. For example, in the case of genes expressed on circular pieces of DNA kn
'/>"/>

Contact: Deborah Williams-Hedges
debwms@caltech.edu
626-395-3227
California Institute of Technology
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. When calculating cell-growth thermodynamics, reconsider using the Gibbs free energy equation
2. Robotic fish designed to perform escape maneuvers described in Soft Robotics journal
3. Report describes Central Hardwoods forest vulnerabilities, climate change impacts
4. Dinosaur fossils from China help Penn researchers describe new Titan
5. 7 new species of nearctic wasps described and illustrated
6. 91 new species described by California Academy Of Sciences in 2013
7. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
8. The Gorgons of the eastern Pacific: scientists describe 2 new gorgonian soft coral species
9. NIH scientists describe how anthrax toxins cause illness, death
10. Scientists from Mainz and Antananarivo describe Lavasoa Dwarf Lemur as new primate species
11. Researchers describe potential for MERS coronavirus to spread internationally
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
An equation to describe the competition between genes
(Date:11/6/2014)... groundbreaking paper from a team of Florida State University ... plants could adapt to and survive environmental swings such ... the latest issue of the journal The Plant ... of DNA and proteins) is organized in a cell ... genes are turned on and others are turned off. ...
(Date:11/6/2014)... Except when that predator runs so fast that it essentially ... is the fastest creature on Earth. Some of these half-inch-long ... five miles per hour). The fastest human can do about ... tiger beetle, a person would have to hit 480 miles ... At peak speeds, everything becomes a blur. They can,t gather ...
(Date:11/5/2014)... Fidel Santamaria, associate professor of biology in the ... researchers in the nation selected to receive a ... Grant for Exploratory Research (EAGER). The funding supports ... support researchers to create new technology that will ... Santamaria, complex behaviors in neuroscience are broken into ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2The tiger beetle: Too fast to see 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... Bioengineers have taken a small step toward improving physical recovery ... how limb motion is encoded in the nervous system plays ... Published in the November 25, 2009 issue of ... responsible for motor learning may help scientists design rehabilitation protocols ...
... You can conserve fish and eat them too, according ... with a team of experts. "We found that ... fish, you can put the Marine Protected Areas in ... fisheries more profitable," said Christopher Costello, economist and professor ...
... the University of Sheffield have scooped an international award in ... make the production of alternative biofuels more energy efficient. ... use in the production of alternative renewable fuels, to replace ... biofuels currently requires vast amounts of power and when the ...
Cached Biology News:Observation about how nervous system learns and encodes motion could improve stroke recovery 2Observation about how nervous system learns and encodes motion could improve stroke recovery 3Environmentalists and fishing community can both win, say experts 2Scientists' breakthrough in production of biofuels 2
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... Bifluoride Industry” is a professional and in-depth research ... Ammonium Bifluoride information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 In keeping ... giving customers a bevy of last-minute Thanksgiving savings. The ... and offers across all product lines this holiday weekend ... , Thanksgiving, Black Friday, and Cyber Monday are right ... own thanks to both loyal customers and those looking ...
(Date:11/26/2014)... HOUSTON and PHILADELPHIA , ... the most demanding and unforgiving environments. Human exploration of ... cognitive performance to ensure mission safety and success, and ... cognitive performance for mission success, little is known about ... aspects of cognition are primarily affected. Now, ...
(Date:11/26/2014)... MD (PRWEB) November 26, 2014 On ... invite the Baltimore and Washington D.C. science community to ... , The event, sponsored by the Protein Society, will ... UMBC’s University Center, Room 312. Through discussion, presentations ... and structural importance of proteins, their role in the ...
Breaking Biology Technology:Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4
... VALENCIA, Calif., Nov. 20 MannKind,Corporation (Nasdaq: MNKD ... and cancer, announced today that it,will present at the ... AM ET at the Pierre Hotel in New York, ... the live web cast of the,presentation in the Investor ...
... Nov. 20 Sports and,nutritional product manufacturer, Natural ... announced today that it has,launched an international marketing ... Relief Cream. Made from a combination of,botanical and ... the internet and television. Natural Nutrition,s BLUE ...
... Nov. 20 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ... developing, manufacturing and marketing biopharmaceutical,products, announces today that ... the 19th Annual Piper Jaffray Health Care Conference ... November 27, 2007 at 4:30 P.M. EST. ...
Cached Biology Technology:Natural Nutrition Launches International Marketing Campaign for New All Natural Analgesic: BLUE LIGHTNING(TM) Fast Pain Relief 2