Navigation Links
An economical, effective and biocompatible gene therapy strategy promotes cardiac repair
Date:7/6/2012

Dr Changfa Guo, Professor Chunsheng Wang and their co-investigators from Zhongshan hospital Fudan University, Shanghai, China have established a novel hyperbranched poly(amidoamine) (hPAMAM) nanoparticle based hypoxia regulated vascular endothelial growth factor (HRE-VEGF) gene therapy strategy which is an excellent substitute for the current expensive and uncontrollable VEGF gene delivery system. This discovery, reported in the June 2012 issue of Experimental Biology and Medicine, provides an economical, feasible and biocompatible gene therapy strategy for cardiac repair.

Transplantation of VEGF gene manipulated mesenchymal stem cells (MSCs) has been proposed as a promising therapeutic method for cardiac repair after myocardium infarction. However, the gene delivery system, including the VEGF gene and delivery vehicle, needs to be optimized. On one hand, long-term and uncontrollable VEGF over-expression in vivo has been observed to lead to hemangioma formation instead of functional vessels in animal models. On the other hand, though non-viral gene vector can circumvent the limitations of virus, drawbacks of the current non-viral vectors, such as complex synthesis procedure, limited transfection efficiency and high cytotoxicity, still needs to be overcome.

Co-investigators, Drs. Kai Zhu and Hao Lai, said "Hypoxia response elements were inserted into the promoter region of VEGF gene to form HRE-VEGF, which provided a safer alternative to the conventionally available VEGF gene". "The HRE-VEGF up-regulates gene expression under hypoxic conditions caused by ischemic myocardium and turns it off under normoxia condition when the regional oxygen supply is adequate."

The hPAMAM nanoparticles, which exhibit high gene transfection efficiency and low cytotoxicity during the gene delivery process, can be synthesized by a simpler and more economical one-step/pot polymerization technique. Drs. Zhu and Lai, said "Using the hPAMAM based gen
'/>"/>

Contact: Dr. Changfa Guo
guo.changfa@zs-hospital.sh.cn
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
2. Lab tests show arthritis drug effective against global parasite
3. As deadly cat disease spreads nationally, MU veterinarian finds effective treatment
4. Urgent research needed to determine most effective follow-up care for lung cancer patients
5. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
6. More effective method of imaging proteins
7. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
8. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
9. Gene therapy for hearing loss: Potential and limitations
10. New data suggests interferon-free therapy around the corner for HCV patients
11. Nanobubbles plus chemotherapy equals single-cell cancer targeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
(Date:11/21/2014)... -- According to a new market research ... Access Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), ... Geography - Global Forecasts to 2020", published by MarketsandMarkets, ... around $25 Billion in 2014 and is expected to ... of 8.69%. Browse 116 market data Tables ...
(Date:11/21/2014)... -- C-Labs LLC, a leading provider of remote and ... announced the appointment of John Traynor to ... advisor to the firm, Mr. Traynor will now oversee ... out of the C-Labs office in Redmond, ... , Chief Executive Officer. Photo - ...
Breaking Biology News(10 mins):First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... 2011 In a new study scientists at NYU Langone ... be improved. The new findings, published online November 20, 2011, ... the loss of smell due to aging or disease. ... A. Wilson, PhD, professor of child and adolescent psychiatry at ...
... University of British Columbia researchers reveals how the effect of ... fisheries practices. "Fisheries are already providing fewer fish and ... says Rashid Sumaila, principal investigator of the Fisheries Economics Research ... "We could be earning interest, but instead we,re fishing away ...
... Suitable habitat for native fishes in many Great Plains ... from the High Plains aquifer and scientists analyzing the ... Results of their study have been published in the ... be replenished seasonally with rain and snow, these regional aquifers ...
Cached Biology News:A failing sense of smell can be reversed 2Effects of climate change to further degrade fisheries resources: UBC researchers 2Great Plains river basins threatened by pumping of aquifers 2Great Plains river basins threatened by pumping of aquifers 3
(Date:12/22/2014)... DIEGO , Dec. 22, 2014 GenomeDx ... the Decipher Prostate Cancer Classifier, a genomic test for ... in node-negative, high-risk men managed by radical prostatectomy without ... radical prostatectomy is relatively uncommon, using tumor genomics to ... of metastatic disease is an important advance. The study ...
(Date:12/19/2014)... and Hershey, PA (PRWEB) December 19, 2014 ... BJCT), a leading developer and manufacturer of needle-free ... into an agreement with Immunomic Therapeutics, Inc. (“ITI”) ... needle-free injection device with its LAMP™ vaccine platform. ... option for an exclusive Worldwide license to the ...
(Date:12/19/2014)... CITY, Calif. , Dec. 19, 2014 Bina ... , USA) announced today that they have been acquired ... 1,2 is a privately held company that provides ... of next generation sequencing (NGS) data for the academic ... the Roche Sequencing Unit, and will continue to focus ...
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 LayerBio ... for ophthalmology and wound care. The National Eye Institute ... awarded LayerBio a Phase I SBIR grant to develop ... Cataracts are the most common cause of vision loss ... of blindness worldwide. According to Dr. Ken Mandell, LayerBio’s ...
Breaking Biology Technology:Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2
... 30 /PRNewswire-FirstCall/ - ICBS Limited,(PINKSHEETS: ICBM), today announced ... Bacteria Bank Ltd., is a Bio medical ... for use in medical research, located,in Montreal Canada. ... a world,renowned bacteriologist. Dr. Karl Weiss is ...
... 30 CryoCor, Inc. (Nasdaq:,CRYO), a medical device ... today that Edward F. Brennan, President and Chief,Executive ... are,scheduled to present at the CIBC World Markets ... Tuesday, November 6, 2007 at 3:40 p.m. ET ...
... ST. LOUIS, Oct. 30 Sigma, a division ... provide researchers,additional Cell Biology solutions through the new ... http://www.sigma.com/ionchannelsolutions ). In addition to the most,comprehensive product ... provide a,wealth of scientific information to assist in ...
Cached Biology Technology:ICBS acquires 30% interest in Bacteria Bank Ltd. 2CryoCor to Present at CIBC World Markets 18th Annual Healthcare Conference 2Sigma Launches The New Ion Channel Solutions Brochure and Web Site 2
...
BD Primaria 35 mm Cell Culture Dish with Easy-Grip design, surface-modified polystyrene for enhanced cell culture. (20/sp, 200/ca) Packaging: 20 / sleeve, 500 / case ...
...
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
Biology Products: