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An easier way to control genes
Date:9/3/2013

cid sequence of the RNAs," Lu says.

The researchers also designed the transcription-control system so that it can be induced by certain small molecules that can be added to the cell, such as sugars. To do this, they engineered the genes for the guide RNAs so that they are only produced when the small molecule is present. Without the small molecule, there is no guide RNA and the targeted gene is undisturbed.

This type of control could be useful for studying the role of naturally occurring genes by turning them on and off at specific points during development or disease progression, Lu says.

Lu is now working on building more advanced synthetic circuits to perform applications such as making decisions based on several inputs from a cell's environment. "We'd like to be able to scale this up and demonstrate the most complex circuits that anyone's ever built in yeast and mammalian cells," he says.


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Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

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