Navigation Links
An abnormal resting-state functional brain network indicates progression towards AD
Date:11/26/2013

Although we know that mild cognitive impairment is a transitional stage between normal aging and Alzheimer's disease, changes in brain networks during this transformation have yet to be studied. Dr. Jie Xiang and colleagues from Taiyuan University of Technology, China constructed brain networks using resting-state functional MRI data that were extracted from four populations (normal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The researchers analyzed the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the resting-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addition, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and Alzheimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments. This study was published in the Neural Regeneration Research (Vol. 8, No. 30, 2013).


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related biology news :

1. Genetic abnormality offers diagnostic hope for childrens cancer
2. Myelodysplastic syndromes (MDS) linked to abnormal stem cells
3. Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
4. DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
5. Fear factor: Missing brain enzyme leads to abnormal levels of fear in mice, reveals new research
6. National survey finds frog abnormalities are rare
7. Has modern science become dysfunctional?
8. Beyond base pairs: Mapping the functional genome
9. Renewed Harvard-BASF initiative to advance functional materials
10. Ordinary skin cells morphed into functional brain cells
11. Functional genetic variation in humans: Comprehensive map published
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
An abnormal resting-state functional brain network indicates progression towards AD
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/15/2016)... --> --> ... Research "Digital Door Lock Systems Market - Global Industry Analysis, ... global digital door lock systems market in terms of revenue ... forecast to grow at a CAGR of 31.8% during the ... enterprises (MSMEs) across the world and high industrial activity driving ...
(Date:3/11/2016)... PUNE, India , March 11, 2016 ... to a new market research report "Image Recognition Market ... by Application (Marketing and Advertising), by Deployment Type (On-Premises ... Global Forecast To 2022", published by MarketsandMarkets, the global ... in 2015 to USD 29.98 Billion by 2020, at ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... THE WOODLANDS, Texas , May 3, 2016 /PRNewswire/ ... board certified plastic surgeon in The Woodlands, ... technology that destroys 24 percent of treated fat cells ... men and woman. Close to 90 percent of Americans ... effective treatment options. Nonsurgical fat reduction procedures are a ...
(Date:5/2/2016)... ... May 02, 2016 , ... StarNet Communications Corp, ( http://www.starnet.com/ ) a ... three Secure Remote Desktop modules to its flagship X-Win32 PC X server. The ... servers to the user’s PC over encrypted SSH. , Traditionally, users of PC X ...
(Date:4/29/2016)... , April 29, 2016 ... by Transparency Market Research "Separation Systems for Commercial ... Growth, Trends, and Forecast 2015 - 2023", the ... at US$ 10,665.5 Mn in 2014 and is ... from 2015 to 2023 to reach US$ 19,227.8 ...
(Date:4/28/2016)... India , April 28, 2016 ... JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, Product ... and Geography - Global Forecast to 2022", published by ... USD 2.94 Billion by 2022, at a CAGR of ... 70 market data Tables and 94 Figures spread through ...
Breaking Biology Technology: