Navigation Links
An IRCM researcher pinpoints the cellular mechanism responsible for modulating the permeability of blood vessels
Date:8/12/2010

Montreal, August 12, 2010 Dr. Jean-Philippe Gratton, Director of the Endothelial cell biology research unit at the Institut de recherches cliniques de Montral (IRCM), identifies a new intracellular mechanism responsible for modulating vascular permeability: the nitrosylation of beta-catenin protein by nitric oxide. This scientific breakthrough could have a possible impact on the treatment of cancerous tumours by altering the permeability of the blood vessels irrigating them. Dr. Gratton's team will publish the results of its research tomorrow in the scientific journal Molecular Cell.

The permeability of blood vessels is determined, in part, by the space between endothelial cells, or the cells lining the inside of all blood vessels. Increasing permeability is an essential step in angiogenesis, the process of formation of new blood vessels. Vascular endothelial growth factor (VEGF) is responsible for triggering angiogenesis, and increasing vascular permeability through the activation of the eNOS enzyme, which in turn produces nitric oxide (NO), an intracellular gas.

"We already knew that NO plays a very important role in the modulation of vascular permeability and that it could represent a target for blocking the growth of tumours," explains Dr. Gratton. "However, we ignored how it worked. We have now shown that beta-catenin is the specific protein targeted by nitrosylation the chemical modification of proteins in endothelial cells by NO."

Nitrosylation of beta-catenin allows endothelial cells to detach from one another, thus increasing vascular permeability. This process could eventually help regenerate damaged arteries after a heart attack. On the contrary, reducing endothelial permeability in cancerous tumours could help prevent the creation of new blood vessels on which they feed, and consequently block their growth. A better understanding of NO's functions could therefore have an important impact on numerous fields of research, as this molecule is involved in many physiological and pathological processes.

"The identification of new cell mechanisms responsible for altering the permeability of blood vessels is a an important step in cancer research," says Dr. Morag Park, Scientific Director of the Canadian Institutes of Health Research's Institute of Cancer Research, "this discovery can potentially have a significant impact on how we treat certain types of tumour growth."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. How algae enslavement threatens freshwater bodies described by Hebrew University researcher
2. Researchers find that one type of stem cell creates a niche for another type in bone marrow
3. VIB and UGent researchers identify key mechanisms of cell division in plants
4. Switchgrass lessens soil nitrate loss into waterways, ISU researcher says
5. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
6. Carnegie Mellon researchers turn up brightness on fluorescent probes
7. Researchers demonstrate highly directional terahertz laser rays
8. Hebrew University researchers identify gene related to chronic pain
9. UC Riverside researchers measure diesel emissions on the freeway
10. Louisiana Tech professor, researcher receives patent for electromagnetic technology
11. Windy cities: Researchers invent new tool to calculate hurricane risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
Breaking Biology Technology: