Navigation Links
An IRCM researcher pinpoints the cellular mechanism responsible for modulating the permeability of blood vessels
Date:8/12/2010

Montreal, August 12, 2010 Dr. Jean-Philippe Gratton, Director of the Endothelial cell biology research unit at the Institut de recherches cliniques de Montral (IRCM), identifies a new intracellular mechanism responsible for modulating vascular permeability: the nitrosylation of beta-catenin protein by nitric oxide. This scientific breakthrough could have a possible impact on the treatment of cancerous tumours by altering the permeability of the blood vessels irrigating them. Dr. Gratton's team will publish the results of its research tomorrow in the scientific journal Molecular Cell.

The permeability of blood vessels is determined, in part, by the space between endothelial cells, or the cells lining the inside of all blood vessels. Increasing permeability is an essential step in angiogenesis, the process of formation of new blood vessels. Vascular endothelial growth factor (VEGF) is responsible for triggering angiogenesis, and increasing vascular permeability through the activation of the eNOS enzyme, which in turn produces nitric oxide (NO), an intracellular gas.

"We already knew that NO plays a very important role in the modulation of vascular permeability and that it could represent a target for blocking the growth of tumours," explains Dr. Gratton. "However, we ignored how it worked. We have now shown that beta-catenin is the specific protein targeted by nitrosylation the chemical modification of proteins in endothelial cells by NO."

Nitrosylation of beta-catenin allows endothelial cells to detach from one another, thus increasing vascular permeability. This process could eventually help regenerate damaged arteries after a heart attack. On the contrary, reducing endothelial permeability in cancerous tumours could help prevent the creation of new blood vessels on which they feed, and consequently block their growth. A better understanding of NO's functions could therefore have an important impact on numerous fields of research, as this molecule is involved in many physiological and pathological processes.

"The identification of new cell mechanisms responsible for altering the permeability of blood vessels is a an important step in cancer research," says Dr. Morag Park, Scientific Director of the Canadian Institutes of Health Research's Institute of Cancer Research, "this discovery can potentially have a significant impact on how we treat certain types of tumour growth."


'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. How algae enslavement threatens freshwater bodies described by Hebrew University researcher
2. Researchers find that one type of stem cell creates a niche for another type in bone marrow
3. VIB and UGent researchers identify key mechanisms of cell division in plants
4. Switchgrass lessens soil nitrate loss into waterways, ISU researcher says
5. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
6. Carnegie Mellon researchers turn up brightness on fluorescent probes
7. Researchers demonstrate highly directional terahertz laser rays
8. Hebrew University researchers identify gene related to chronic pain
9. UC Riverside researchers measure diesel emissions on the freeway
10. Louisiana Tech professor, researcher receives patent for electromagnetic technology
11. Windy cities: Researchers invent new tool to calculate hurricane risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... MA (PRWEB) , ... June 23, 2016 , ... ... Peel Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute ... platform of microbial tests introduced last year,” stated Bob Salter, Vice President of ...
(Date:6/23/2016)... -- The Biodesign Challenge (BDC), a university competition that asks ... systems and biotechnology, announced its winning teams at the ... York City . The teams, chosen ... MoMA,s Celeste Bartos Theater during the daylong summit. Keynote ... of architecture and design, and Suzanne Lee , ...
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report ... detail how a patient who developed lymphedema after being treated for breast cancer benefitted ... change the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
Breaking Biology Technology: