Navigation Links
An IRCM researcher pinpoints the cellular mechanism responsible for modulating the permeability of blood vessels
Date:8/12/2010

Montreal, August 12, 2010 Dr. Jean-Philippe Gratton, Director of the Endothelial cell biology research unit at the Institut de recherches cliniques de Montral (IRCM), identifies a new intracellular mechanism responsible for modulating vascular permeability: the nitrosylation of beta-catenin protein by nitric oxide. This scientific breakthrough could have a possible impact on the treatment of cancerous tumours by altering the permeability of the blood vessels irrigating them. Dr. Gratton's team will publish the results of its research tomorrow in the scientific journal Molecular Cell.

The permeability of blood vessels is determined, in part, by the space between endothelial cells, or the cells lining the inside of all blood vessels. Increasing permeability is an essential step in angiogenesis, the process of formation of new blood vessels. Vascular endothelial growth factor (VEGF) is responsible for triggering angiogenesis, and increasing vascular permeability through the activation of the eNOS enzyme, which in turn produces nitric oxide (NO), an intracellular gas.

"We already knew that NO plays a very important role in the modulation of vascular permeability and that it could represent a target for blocking the growth of tumours," explains Dr. Gratton. "However, we ignored how it worked. We have now shown that beta-catenin is the specific protein targeted by nitrosylation the chemical modification of proteins in endothelial cells by NO."

Nitrosylation of beta-catenin allows endothelial cells to detach from one another, thus increasing vascular permeability. This process could eventually help regenerate damaged arteries after a heart attack. On the contrary, reducing endothelial permeability in cancerous tumours could help prevent the creation of new blood vessels on which they feed, and consequently block their growth. A better understanding of NO's functions could therefore have an important impact on numerous fields of r
'/>"/>

Contact: Julie Langelier
julie.langelier@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. How algae enslavement threatens freshwater bodies described by Hebrew University researcher
2. Researchers find that one type of stem cell creates a niche for another type in bone marrow
3. VIB and UGent researchers identify key mechanisms of cell division in plants
4. Switchgrass lessens soil nitrate loss into waterways, ISU researcher says
5. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
6. Carnegie Mellon researchers turn up brightness on fluorescent probes
7. Researchers demonstrate highly directional terahertz laser rays
8. Hebrew University researchers identify gene related to chronic pain
9. UC Riverside researchers measure diesel emissions on the freeway
10. Louisiana Tech professor, researcher receives patent for electromagnetic technology
11. Windy cities: Researchers invent new tool to calculate hurricane risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... all have in common? Unlike most eukaryotic multicellular ... diploid, these organisms are all polyploid, meaning they have ... have 3 and 4 sets of chromosomes, respectively, and ... in fact most plant species are polyploid. Polyploidy, or ... but only recently, with the development of molecular tools, ...
(Date:9/30/2014)... professor and Howard Hughes Medical Institute investigator, and ... recipients in the 2014 round of grants from ... BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative ... September 30, provides more than $3 million in ... , The BRAIN Initiative, launched last year, is ...
(Date:9/30/2014)... of Medicine reports positive results of a phase ... subset of lung cancer marked by rearrangement of the ... with advanced non-small cell lung cancer testing positive for ... with 3 complete responses and 33 partial responses. Median ... disease to resume its growth after being slowed by ...
Breaking Biology News(10 mins):Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Salk scientists receive $3 million for BRAIN Initiative grant 2NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2
... bites, and business struggle to stay primed, researchers in ... and business practice is needed if a company is ... Practice from Inderscience Publishers, the team explains how businesses ... Palmira Lpez-Fresno of "STIGA" in Barcelona is working ...
... An undergraduate student at Rensselaer Polytechnic Institute has learned ... help the medicine go down. In fact, with his ... Among the most important and complex molecules in the ... how cells communicate with one another. Graduating senior Jeffery ...
... discovery of the duck-billed, egg-laying, otter-footed, beaver-tailed, venomous platypus ... must be a hoax. Sketches of its appearance were ... that the oddness of the platypus, looks isn,t just ... avian, reptilian and mammalian lineages that may hold clues ...
Cached Biology News:Programmed death boosts business 2Undergrad has sweet success with invention of artificial Golgi 2Undergrad has sweet success with invention of artificial Golgi 3Platypus genome decoded 2Platypus genome decoded 3
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide is ... nematodes. Nematodes are microscopic parasitic roundworms, found in ... inside other plants and animals. Nematicides have tended ... other properties promoting migration through the soil. A ... 1,000 plant-parasitic nematodes. With more than 10,000 species ...
(Date:9/30/2014)... , Sept. 30, 2014 CORD:USE Cord Blood ... announce that it has entered into an Equity and ... which has licensed a series of patented technologies for the ... possible clinical applications.  Tianhe is performing Phase I/II clinical ... Spain using Tianhe,s Stem Cell Educator ...
(Date:9/30/2014)... BioHealth Innovation, Inc. (BHI), a ... and increasing access to early-stage funding in ... Tania Fernandez , Ph.D., has joined the BHI ... a member of the management team for a new ... million in seed and early-stage equity investments to therapeutics, ...
Breaking Biology Technology:A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2
... April 13, 2011 Today Massachusetts Life Sciences Center ... officials,  Organogenesis, Inc. President & CEO Geoff MacKay and ... Dan Road.  Upon completion in 2013, the company expects ... cell manufacturing plant.   Organogenesis is in ...
... Biosciences, a global manufacturer of products designed to ... labor intensive, today announced an agreement with Bruker ... microbial identification from cultures using MALDI-TOF proteomic finger-printing, ... research, and veterinary laboratory customers. The compatible product ...
... published in the March 14 edition of the ... and testing of a new type solar cell using ... nanowires (described has "quantum coaxial cables") had previously been ... chemically more stable large bandgap inorganic materials, should also ...
Cached Biology Technology:Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 2Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 3Organogenesis, Life Sciences Center Break Ground on World's Largest Automated Living Cell Manufacturing Plant 4Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 2Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 3Magellan Biosciences Announces Agreement with Bruker to Provide Microbiology Tools to Battle Drug Resistance 4Device proves solar cell potential of high bandgap inorganic nanowire arrays 2Device proves solar cell potential of high bandgap inorganic nanowire arrays 3
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide White ... CHAPS and CHAPSO. Has reduced electrostatic interactions ... chromatography on DEAE-cellulose. Aggregation number: 8-16. ... H 2 O. Aggregation number 8 - ...
... 2000 Pipette is a synonym for pipetting ... robust design, and superior operating comfort. Its ... the measuring stroke and blow-out as well ... system ensures utmost accuracy and precision. Ejection ...
... This protein is a member of the ... Members of the PAX family typically contain ... homeodomain. These proteins play critical roles during ... 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand ...
Compact, portable device, seals 96 and 384 well plates with preset temperature optimised for Eppendorf heat sealing foils and films. Suitable for plates of different heights. AC input: 50/60 Hz230 V...
Biology Products: