Navigation Links
An Alzheimer's vaccine?
Date:11/12/2007

Could a new vaccine be the key to stopping Alzheimers disease" A new research study from the Oklahoma Medical Research Foundation (OMRF) shows that immunization could offer a way to blunt or even prevent the deadly, memory-robbing disease.

OMRF scientists immunized Alzheimers mice with a protein believed to play a key role in the disease-causing process. The mice who received the vaccination showed a significant reduction in the build-up of protein plaques that, when present in the brain for long periods of time, are believed to cause the cell death, memory loss and neurological dysfunction characteristic of Alzheimers.

The immunized mice also showed better cognitive performance than control mice had not received the vaccine.

These results are extremely exciting, said Jordan Tang, Ph.D., the OMRF researcher who led the study. They certainly show that this vaccination approach warrants additional investigation as a therapy for Alzheimers disease.

The new research appears in The Journal of the Federation of American Societies for Experimental Biology.

Tang and his colleagues at OMRF previously had identified the cutting enzyme (known as memapsin 2) that creates the protein fragments believed to be the culprit behind Alzheimers. In the current study, researchers used mice that had been genetically engineered to develop symptoms of Alzheimers, then immunized the animals with memapsin 2.

What we saw is that the mice immunized with memapsin 2 developed 35 percent fewer plaques than their non-vaccinated counterparts, said Tang. Those immunized mice also performed better than control mice in tests designed to assess their cognitive function.

Tangs work with memapsin 2 also has led to the creation of an experimental drug to treat Alzheimers disease. That drug, which works by inhibiting the cutting enzyme, began human clinical trials in the summer of 2007.

Tang emphasized that the vaccine approach sh
'/>"/>

Contact: Adam Cohen
adam-cohen@omrf.org
405-271-7159
Oklahoma Medical Research Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Paradigm shift in Alzheimerss research: new treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... March 23, 2015 SoundView Technology Group issues a ... NXTD ) Wocket smart wallet. SoundView was one of the ... their experience with the Wocket in multiple scenarios and outlets. ... Foods and other retailers, making both debit and credit card ... also says, "If the company meets their plans in 2015, ...
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has ... Strategic Business Report" report to their offering. ... US$ Thousands. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for ...
(Date:3/17/2015)... , March 17, 2015 ... company specializing in clinical study management systems, is ... in attendance at ARENA,s Outsourcing in Clinical Trials ... This event provides an excellent forum for MedNet ... flexible and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... is available in German . ... and evolution of these networks are among the most ... of Vienna, and physicist Hernan Makse, City University New ... are of high interest not only for evolutionary research ...
... outgrowing teenage infatuations with the girl next door, adult ... attractions to the wife next door, according to a ... levels dropped when they were interacting with the marital ... that keep men from constantly competing for each others, ...
... their children to try new foods, but some kids just won,t ... Chapel Hill reveals that the reason these kids fear new foods ... to do with their genes. The work, led by Myles ... Global Public Health, adds to the growing body of knowledge that ...
Cached Biology News:Novel insights into the evolution of protein networks 2Novel insights into the evolution of protein networks 3Men may have natural aversion to adultery with friends' wives 2Genes may be reason some kids are picky about food 2
(Date:4/1/2015)... National recruitment firm Slone Partners is pleased ... of Sales at Optimal Medicine, an international digital health ... brings over 20 years experience in healthcare information technology ... including Dell Services Healthcare, Medsphere Systems and McKesson. ... for accomplishing the goals Optimal Medicine had for this ...
(Date:3/31/2015)... 31, 2015 Eastern Kentucky University ... online bachelor’s of criminal justice degree programs by ... to inspiring ideas and high quality educational opportunities,” ... the University. We are confident that students will ... This is the site’s first “Students before Profits” ...
(Date:3/31/2015)... 31, 2015   Mapi expands Pharmacovigilance ... Affairs and global Risk Management strength with the ... announced acquisition . Pharmacovigilance ... a global team that includes physicians, pharmacists, and ... experience in navigating complex safety requirements throughout the ...
(Date:3/31/2015)... March 31, 2015 Today, Cryos International, ... relocation of their U.S. facilities and inventory from New ... years of experience, Cryos’ relocation is a reflection of ... move to Orlando was completed during the first weekend ... opening taking place on April 6. The new facility ...
Breaking Biology Technology:Slone Partners Fills Head of Sales at Optimal Medicine 2EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Mapi expands Pharmacovigilance and Risk Management capabilities 2Mapi expands Pharmacovigilance and Risk Management capabilities 3Cryos International Completes Groundbreaking Sperm Migration to Orlando, Florida 2
... 16, Shire plc (LSE: SHP, NASDAQ: SHPGY ... U.S. District Court of the Southern District of,New York ... Shire,s patents: U.S. Patent No. 5,968,976 (",976 Patent"); U.S. ... , The lawsuit was filed ...
... and megabase capacity for the next generation sequencing ... febit today announced the official launch ... several biomedical studies of early access customers over ... and deep sequencing coverage for a broad range ...
... tester machine for medical pouches & sachets from Ireland-based manufacturer Sepha. ... ... A leak tester machine for pharmaceutical and medical pouches ... makes its U.S. market debut through U.S. distributor Service Industries ...
Cached Biology Technology:Shire Files Lawsuit Against Barr Laboratories for Infringement of FOSRENOL(R) (Lanthanum Carbonate) Patents 2Automated Sequence Capture for Next-Generation Sequencing Paves the Way for Personalized Medicine 2Automated Sequence Capture for Next-Generation Sequencing Paves the Way for Personalized Medicine 3U.S. Distributor Debut for PAKSCAN - a Pouch & Sachet Leak Tester Machine from Ireland-based Sepha Ltd. 2U.S. Distributor Debut for PAKSCAN - a Pouch & Sachet Leak Tester Machine from Ireland-based Sepha Ltd. 3
... Zero -mr agarose is specifically ... detectable endoosmosis, and is recommended ... molecular weight proteins or complexes ... degrees of molecular sieving in ...
... BioGenex VISION Sytem is a highly ... with proprietary digital imaging and automation ... image acquisition, analysis, archving/retrieval and colored ... with the industry's fastest scanning and ...
... The CHEMICON APO-BRDU Kit is ... DNA breaks and total cellular DNA to ... The kit contains the instructions and reagents ... positive and negative control cells for assessing ...
... a 2-color staining method for labeling DNA ... apoptotic cells by flow cytometry. The kit ... measuring apoptosis in cells including positive and ... washing, reaction and rinsing buffers for processing ...
Biology Products: