Navigation Links
Amyloid beta in the brain of individuals with Alzheimer's disease
Date:3/30/2012

The deposition of amyloid beta in the brain of individuals with Alzheimer's disease is the focus of much research into both its cause and treatment.

While there may not be a consensus as to whether the deposition contributes to the disease or is a consequence of the disease, there is agreement that it is not favoured thermodynamically, meaning that something else is promoting the process.

Other proteins are often co-deposited in vivo with amyloid beta and one such protein is serum amyloid P component (or SAP). Recent evidence has suggested that SAP is elevated in Alzheimer's disease and a team of researchers from Keele University in Staffordshire, UK, led by Professor Chris Exley, has shown that physiologically-significant concentrations of SAP promote the deposition of amyloid beta under conditions approaching those found in vivo.

Professor Exley said: "We have shown that SAP is bound by fibrils of amyloid beta and that this interaction stabilises the fibrils over timescales which are physiologically significant. This is the first example of a physiologically significant biomolecule promoting and stabilising the formation of amyloid fibrils of amyloid beta 42 under near-physiological conditions."

The group also found that this property of SAP was enhanced in the presence of aluminium, a metal which has also been shown to be co-deposited with amyloid beta in Alzheimer's disease. There have been recent efforts to reduce the plasma concentration of SAP as a therapy for Alzheimer's disease and the research provides strong evidence that SAP is involved in the deposition of amyloid beta 42 in Alzheimer's disease and that by reducing the plasma concentration of SAP it might also reduce the deposition of amyloid beta. Their observations support serum amyloid P component as a therapeutic target in Alzheimer's disease.


'/>"/>
Contact: Chris Stone
c.w.stone@mac.keele.ac.uk
44-178-273-3375
IOS Press
Source:Eurekalert

Page: 1

Related biology news :

1. Early role of mitochondria in AD may help explain limitations to current beta amyloid hypothesis
2. New therapy targets for amyloid disease
3. Scientists remove amyloid plaques from brains of live animals with Alzheimers disease
4. Autism risk gene linked to differences in brain structure
5. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
6. Friendly to a fault, yet tense: Personality traits traced in brain
7. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
8. University of Alberta led research may have discovered how memories are encoded in our brains
9. Step forward in research into new treatments for brain edema
10. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
11. Strong scientific evidence that eating berries benefits the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2020)... ... May 20, 2020 , ... Law Enforcement has always been a highly ... us. The positions of these men and women put them constantly in harm’s way ... rules precisely. Officers have always had to face very high daily stress. Now, COVID-19 ...
(Date:5/14/2020)... , ... May 14, 2020 , ... ... board for medical sales representatives, found the 2019 average medical sales rep total ... risk being shadowed by uncertainties amid the COVID-19 global crisis. , The MedReps ...
(Date:5/1/2020)... , ... April 30, 2020 , ... ... announced an alliance with Corritori Consulting Inc., a biopharmaceutical and regulatory services advisor. ... and companion diagnostics industries. Flagship and Corritori are taking a collaborative approach to ...
Breaking Biology News(10 mins):
(Date:4/22/2020)... (PRWEB) , ... April 20, 2020 , ... ... offices in Cambridge, MA, announced today that Omixon’s founder and chairman Dr. Attila ... of Omixon’s flagship product Holotype HLA since 2014 before stepping into the CEO ...
(Date:4/7/2020)... ... April 06, 2020 , ... Red Nucleus, a leading provider ... announced the release of at-home virtual learning resources for all client partners. , ... safety of our employees as we continue to implement measures to safeguard the ...
(Date:4/1/2020)... Conn. (PRWEB) , ... March 31, 2020 , ... ... Science, Inc. (P2) announce the signing of a Joint Development Agreement that ... , Bedoukian Research, Inc. is a global leader in the supply of high-quality ...
(Date:3/13/2020)... (PRWEB) , ... March 12, 2020 , ... ... with the APC Microbiome Ireland SFI Research Center (APC), a pioneer in the ... the body and play a significant role in human health, based at University ...
Breaking Biology Technology: