Navigation Links
Amniotic fluid stem cells repair gut damage
Date:3/24/2013

Stem cells taken from amniotic fluid were used to restore gut structure and function following intestinal damage in rodents, in new research published in the journal Gut. The findings pave the way for a new form of cell therapy to reverse serious damage from inflammation in the intestines of babies.

The study, funded by Great Ormond Street Hospital Children's Charity, investigated a new way to treat necrotizing enterocolitis (NEC), where severe inflammation destroys tissues in the gut. NEC is the most common gastrointestinal surgical emergency in newborn babies, with mortality rates of around 15 to 30 per cent in the UK.

While breast milk and probiotics can help to reduce the incidence of the disease, no medical treatments are currently available other than surgery once NEC sets in. Surgical removal of the dead tissue shortens the bowel and can lead to intestinal failure, with some babies eventually needing ongoing parenteral nutrition (feeding via an intravenous line) or an intestinal transplant.

In the study, led by the UCL Institute of Child Health, amniotic fluid stem (AFS) cells were harvested from rodent amniotic fluid and given to rats with NEC. Other rats with the same condition were given bone marrow stem cells taken from their femurs, or fed as normal with no treatment, to compare the clinical outcomes of different treatments.

NEC-affected rats injected with AFS cells showed significantly higher survival rates a week after being treated, compared to the other two groups. Inspection of their intestines, including with micro magnetic resonance imaging (MRI), showed the inflammation to be significantly reduced, with fewer dead cells, greater self-renewal of the gut tissue and better overall intestinal function.

While bone marrow stem cells have been known to help reverse colonic damage in irritable bowel disease by regenerating tissue, the beneficial effects from stem cell therapy in NEC appear to work
'/>"/>

Contact: Jenny Gimpel
jenny.gimpel@gosh.org
44-020-723-93043
University College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. Amniotic fluid yields alternatives to embryonic stem cells
2. UT Arlington engineer wins NSF award to support microfluidic analyses of tissue, cell samples
3. Can compressed fluids increase enzyme activity in industrial bioprocesses?
4. Biological and Pharmaceutical Complex Fluids Conference
5. Engineers use droplet microfluidics to create glucose-sensing microbeads
6. Computer simulations yield clues to how cells interact with surroundings
7. Insights into the immune system, from the fates of individual T cells
8. IUPUI stem cell research could expand clinical use of regenerative human cells
9. Cell Transplantation study finds stem cells in deer antler
10. University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
11. White blood cells found to play key role in controlling red blood cell levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... news release is available in German . ... to pay the protection money demanded of him, he can ... seldom required, however, as fear of the consequences is enough ... observed in parasitic birds, which lay their eggs in other ... out, the brood parasites take their revenge by destroying the ...
(Date:4/17/2014)... deforestation and fragmentation of forests in the Amazon ... forests, contributing to rapid and widespread forest loss ... researchers., The findings show that forests in the ... droughts coupled with forest fires lead to large-scale ... Jennifer Balch, assistant professor of geography, Penn State. ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Structure of sodium channels different than previously believed 2
... Tibetan sacred mountain Khawa Karpo, a verdant, snow-capped high ... world,s most exceptional areas of plant and animal diversity ... endangered snow leopard. Monsoon rains, precipitous topography dissected by ... have influenced this region, valued not only for its ...
... 12, 2012 Wake Forest Baptist Medical Center ... academic and clinical research and discoveries into marketable products ... Wake Forest Innovations, is being led by Chief Innovation ... is also President of the Piedmont Triad Research ...
... in Northern California and Oregon may be linked to a ... by scientists from the University of California, Davis. Their findings, ... could lead to a better understanding of how viruses can ... March 2010 by scientists at the UC Davis School of ...
Cached Biology News:New book details the biological and cultural diversity of Khawa Karpo, sacred mountain of Tibet 2New book details the biological and cultural diversity of Khawa Karpo, sacred mountain of Tibet 3Wake Forest Baptist Medical Center Launches Wake Forest Innovations 2Wake Forest Baptist Medical Center Launches Wake Forest Innovations 3Emerging virus in raccoons may provide cancer clues 2Emerging virus in raccoons may provide cancer clues 3
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, ... exclusive agreement with R-Pharm, a leading Russian pharmaceutical company, ... the Russian Federation , ... Independent States (CIS). Nemonoxacin is a novel antibiotic for the ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... 2011 ReportsnReports   ... & Recovery Solutions, Electric Vehicle, Telemedicine, NFC PoS Terminal, ... store Technoavio / Infiniti Research has ... geographies. Priced differently based on the market and geography ...
... a new way to develop straight carbon nanofibers on a ... in novel biomedical research tools, solar cells, water repellent coatings ... relies on ions to ensure the nanofibers are straight, rather ... the first time, that I know of, where someone has ...
... Elsevier, a world-leading provider of scientific, technical ... National University of Singapore (NUS), a leading global ... SgCodeJam24. This "Hackathon", a 24-hour programming competition, encourages ... advance the search and discovery process of scientific ...
Cached Biology Technology:ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 2ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 3ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 4ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 5Ions control shape of nanofibers grown on clear substrate 2Ions control shape of nanofibers grown on clear substrate 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 2Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 4Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 5
... RapidStak is a fast and ... Its high capacity and reliable ... confident walk away time than typical ... of set-up make for a seamless ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
Recombinant Rhesus Monkey IFN Alpha Activity: 2.9 x 10 8 u/mg...
... dispensers save space and organize gloves, ... garb. They are the perfect benchtop ... in labs, processing and manufacturing. Clear ... the particles they attract. Many other ...
Biology Products: