Navigation Links
Amid the murk of 'gut flora,' vitamin D receptor emerges as a key player
Date:7/7/2010

Within the human digestive tract is a teeming mass of hundreds of types of bacteria, a potpourri of microbes numbering in the trillions that help us digest food and keep bad bacteria in check.

Now scientists have found that the vitamin D receptor is a key player amid the gut bacteria what scientists refer to matter-of-factly as the "gut flora" helping to govern their activity, responding to their cues, and sometimes countering their presence. The work was published online recently in the American Journal of Pathology.

The findings deliver a new lead to scientists investigating how bacteria might play a role in the development of inflammatory bowel diseases such as Crohn's disease or ulceractive colitis. The work complements studies suggesting that Salmonella infection can increase the risk of inflammatory bowel disease.

"Vitamin D deficiency is a known factor in the pathology of inflammatory bowel disease and colon cancer," said microbiologist Jun Sun, Ph.D., of the University of Rochester Medical Center, "but there have been very few reports about how bacteria might play a role by targeting the vitamin D receptor. Our work suggests one possible mechanism, by working through the vitamin D receptor, a sensor and regulator for the majority of functions of vitamin D."

Sun specializes in the actions of bacteria in the body and how their interactions within the body contribute to disease. She has shown that bacteria often found in the human intestine affect molecular signals known to contribute to inflammatory response and cell growth.

Her work with the vitamin D receptor takes place at a time when the molecule is coming under increasing scrutiny. Scientists have associated vitamin D and the receptor with many types of cancer, as well as osteoporosis, heart disease, diabetes, inflammatory bowel disease, and infection.

Sun's team took a close look at the vitamin D receptor in mice and its interactions
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Dont forget the vitamin A when working with its carrier protein
2. Vitamin C supplements may reduce benefit from wide range of anti-cancer drugs
3. Vitamin D a key player in overall health of several body organs, says UC Riverside biochemist
4. Lack of vitamin D linked to Parkinsons disease
5. Vitamin K does not stem BMD decline in postmenopausal women with osteopenia
6. Optimal dose of vitamin E maximizes benefits, minimizes risk
7. Lung airway cells activate vitamin D and increase immune response
8. Could vitamin D save us from radiation?
9. Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease
10. Vitamin D found to fight placental infection
11. Calcium and vitamin D may not be the only protection against bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/12/2014)... happened on the way to dealing with climate ... dollars, worth of previously unreachable oil and natural ... and benefits from "fracking," which requires ... deep into underground rock formations, are the subject ... and government databases. The survey covers not only ...
(Date:9/11/2014)... autism often show a reduced frequency of social ... repetitive solitary behaviors. Autism has also been linked ... involved in processing emotions. Now Caltech researchers have ... that control whether the animal engages in social ... have implications for understanding neural circuit dysfunctions that ...
(Date:9/11/2014)... associate professor of mechanical engineering at Worcester ... the university,s Integrative Materials Design Center (iMdc), ... the National Science Foundation (NSF) to support ... manufacture metal-ceramic composites, which can be used ... efficient, while significantly increasing their performance. , ...
Breaking Biology News(10 mins):Stanford-led study assesses the environmental costs and benefits of fracking 2Stanford-led study assesses the environmental costs and benefits of fracking 3Stanford-led study assesses the environmental costs and benefits of fracking 4Tipping the balance of behavior 2Tipping the balance of behavior 3NSF funds new method for making materials that can make lighter, more efficient vehicles 2NSF funds new method for making materials that can make lighter, more efficient vehicles 3
... lab tests of "killer paper," a material intended for ... preserve foods by fighting the bacteria that cause spoilage. ... contains a coating of silver nanoparticles, which are powerful ... that silver already finds wide use as a bacteria ...
... contain atomic clues as to the habitats in which ... has important implications for predicting the effects of climate ... the animal kingdom. Applying a method previously only ... on plants, scientists from the University of Cambridge can ...
... MOUNTAIN VIEW, Calif., Jan. 10, 2011 Based ... monitoring market, Frost & Sullivan recognizes Cardiocom with ... for Enabling Technology. Cardiocom provides integrated clinical telehealth ... healthcare community. (Logo:   http://photos.prnewswire.com/prnh/20081117/FSLOGO ) ...
Cached Biology News:Insects hold atomic clues about the type of habitats in which they live 2Frost & Sullivan Recognizes Cardiocom as a Technology Enabler for Superior Cost-Effective Remote Chronic Care Management 2Frost & Sullivan Recognizes Cardiocom as a Technology Enabler for Superior Cost-Effective Remote Chronic Care Management 3Frost & Sullivan Recognizes Cardiocom as a Technology Enabler for Superior Cost-Effective Remote Chronic Care Management 4
(Date:9/12/2014)... 2014 Advancing the front lines ... chemical and biological threats is the mission of ... Institute (WPI) and the Georgian National Academy of ... Peace and Security Programme of the North Atlantic ... Research Workshop series, the event is titled “Nanotechnology ...
(Date:9/12/2014)... On Thursday, September 11, 2014, the NASDAQ Composite ended ... the day 0.12% lower at 17,049.00, and the S&P 500 ... as seven out of ten sectors ended the session in ... day at 741.83, down 0.33%, while the index has advanced ... on the following equities: Exelixis Inc. (NASDAQ: EXEL ...
(Date:9/11/2014)... researchers have gained new insight into what may ... neuronal signaling associated with this disease. They did ... of healthy individuals and of patients with schizophrenia ... to release neurotransmitters, such as dopamine, that are ... various disorders. By discovering a simple method for ...
(Date:9/11/2014)... surface of graphene, a one atom thick sheet of ... graphene oxide; a form of graphene that could have ... industries. Applied as paint, it could provide an ultra-strong, ... , Graphene oxide solutions can be used to ... even conventional bricks. After a simple chemical treatment, the ...
Breaking Biology Technology:Worcester Polytechnic Institute to Lead Scientific Workshop on Nanoscale Defenses for Biological and Chemical Threats 2Worcester Polytechnic Institute to Lead Scientific Workshop on Nanoscale Defenses for Biological and Chemical Threats 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 2Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 3Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 4Technical Coverage on Biotech Stocks - Exelixis, Arena Pharma, Novavax, Dendreon, and Amicus Therapeutics 5Stem cells help researchers understand how schizophrenic brains function 2Graphene paints a corrosion-free future 2
... Israel, June 17 BSP Ltd.,( http://www.bsp.co.il/pressall.asp ) ... non-invasive diagnosis and monitoring of Ischemic Heart,Disease, announced ... private,funding round, that included existing shareholders in the ... the HyperQ(TM), a cutting-edge technology that offers,highly reliable, ...
... a trend of unprecedented,growth in biotechnology innovation, targeted ... in the past year in,terms of development and ... at the 2008 BIO International Convention in San ... the need to measure,innovation in the market, in ...
... 17 /PRNewswire-FirstCall/ - Oncothyreon Inc.,(Nasdaq: ONTY ) ... in,a Phase 1 trial of PX-866 in patients ... compound designed to inhibit the activity of,phosphatidylinositol-3-kinase (PI-3K), ... a potent inhibitor of PI-3K, a component of ...
Cached Biology Technology:BSP Raises $2.6 Million Dollars From Private Investors 2In a Year of Unprecedented Growth for Biotechnology Innovation, Targeted Therapies Gain Most Significant Traction, According to New Deloitte Study 2In a Year of Unprecedented Growth for Biotechnology Innovation, Targeted Therapies Gain Most Significant Traction, According to New Deloitte Study 3In a Year of Unprecedented Growth for Biotechnology Innovation, Targeted Therapies Gain Most Significant Traction, According to New Deloitte Study 4In a Year of Unprecedented Growth for Biotechnology Innovation, Targeted Therapies Gain Most Significant Traction, According to New Deloitte Study 5Oncothyreon initiates Phase 1 trial of PX-866 cancer compound 2Oncothyreon initiates Phase 1 trial of PX-866 cancer compound 3Oncothyreon initiates Phase 1 trial of PX-866 cancer compound 4
Fingerprinting II dimensioning techniques is an optional module that adds principal component analysis, multidimensional scaling, discriminant analysis and MANOVA, and self-organizing maps to the Fin...
Fingerprinting II Informatix optional matrix types module, is an optional module that adds external similarity and distance matrix functions to the Fingerprinting II Informatix software package....
... Dyad instrument is the most advanced thermal ... world-class thermal performance, the Dyad also boasts ... as point-and-click navigation via touch pad or ... easily and economically expanded to a four-bay ...
...
Biology Products: