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American Physiological Society's latest conference focuses on integrative biology of exercise

BETHESDA, Md. (Sept. 20, 2012) The latest conference to be sponsored by the American Physiological Society (APS) focuses on the molecular mechanisms involved in exercise-mediated physiological changes in the body, including metabolic, cardiovascular, neurological, and dynamic molecular and cellular pathways. Entitled Integrative Biology of Exercise VI, the meeting will be held October 10-13, 2012 in Westminster, Colorado. The full program is available online at An overview of the program is below.

Thursday, October 11, 2012

Plenary Lecture: Toward Personalized Lifestyle Medicine
Geoffrey Ginsburg, M.D., Ph.D., of the Duke Institute for Genome Sciences and Policy will deliver this talk on integrating personalized medicine and healthcare.

Symposia I: Integrating Human "Omics" to the Molecular Physiology of Exercise
Speakers will discuss pathways and mechanisms involved in exercise-modulated improvements in health, focusing on small molecule metabolites, skeletal muscle gene expression, the proteome and integrative molecular physiology of exercise.

Symposia II: Personalized Exercise Prescription Based Upon Integrative Biology
Experts will explore genetic, transcriptomic, phenotypic and pharmacologic considerations in identifying and predicting individual response to exercise regimens.

Symposia III: Mechanisms Behind Adaptations to Physical Activity/Inactivity
The session will focus on signaling pathways, gene expression and posttranslational modifications in skeletal muscle remodeling and adaptation in activity and inactivity.

Symposia IV: Acetylation: Linking changes in NAD to Metabolism and Growth
This session will provide insights into the role of NAD+ and its role in mitochondrial protein synthesis, metabolism, and metabolic diseases.

Friday, October 12, 2012

Plenary Lecture: Adaptations of the Heart: Traditional and Non-Traditional Research Approaches
Leslie Leinwand, Ph.D. of the Department of Molecular, Cellular and Developmental Biology at the University of Colorado, Boulder will discuss cardiac and skeletal muscle development and function, gene therapy and cardiac genetic disease.

Symposia V: Cardiovascular Benefits of Exercise: Insights from Animal Studies
Speakers will address emerging research on connections between exercise and arrhythmia, adaptation to physical activity, and molecular mechanisms of cardioprotection.

Symposia VI: Cardiovascular Benefits of Exercise: Insights from Human Studies
The session will cover improving exercise tolerance in heart failure, reversal of impaired cardiac function in obese adolescents, the effect of exercise on left ventricular compliance and diastolic function in the elderly and attenuating premature cardiovascular aging in Type 2 diabetes through exercise.

Symposia VII: Fit, Fat and Lean Liver: Exercise Adaptations in Non-Traditional Tissues
Speakers will discuss the mechanism by which exercise can prevent or reverse steatosis, the effects of exercise on IL-6 production, and the control of adipose tissue metabolism, adipose tissue oxidation and metabolism.

Symposia VIII: Skeletal Muscle Lipid Droplet Biology in Exercise and Disease
Experts will present findings on liquid droplet dynamics in fat accumulation and metabolic regulation.

Saturday, October 13, 2012

Symposia IX: Physical Activity is Necessary for Optimal Brain Function
Researchers will discuss mechanisms of protective effects of exercise and physical activity in neurological function, and prevention of cognitive decline and dementia.

Symposia X: The Impact of Heat Shock Protein Expression on Muscle Metabolism, Exercise Capacity and Disease Prevention
Speakers will present evidence for the functional effects and mechanisms of heat shock proteins and their role in aging, mitochondrial function, apoptotic pathways, insulin sensitivity, myocardial protection and more.

Symposia XI: Hot Topics in Exercise Physiology
Researchers will discuss glycolytic muscle development and metabolic homeostasis, mitochondria, hyperglycemia, redox and cardiac function in Type 2 diabetes, and X-ROS signaling in striated muscle.

Symposia XII: Unified Cellular and Molecular Mechanism of Muscle Hypertrophy
Experts will discuss evidence of biological mechanisms of muscle hypertrophy including mTORC1, myostatin and satellite cells.


Contact: Donna Krupa
American Physiological Society

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