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American Health Assistance Foundation announces grants to advance promising vision research
Date:7/25/2012

a is a leading cause of irreversible blindness, affecting more than 60 million people.

Subjects addressed in the 11 new glaucoma research grants funded by AHAF include:

  • Studying the Increased Risk of Glaucoma with Alzheimer's Disease:

    Peter P. De Deyn, M.D., Ph.D., of the University of Antwerp, Belgium, is examining how Alzheimer's patients may be at increased risk of developing glaucoma. De Deyn's theory is that people with Alzheimer's disease may have reduced pressure in their cerebrospinal fluid (or CSF, which bathes the brain, eyes, and spinal cord), which may be caused by the brain shrinkage seen in Alzheimer's disease. The combination of reduced CSF pressure and a high eye pressure may play an important role in the development of glaucoma in Alzheimer's disease patients. De Deyn is conducting a human clinical trial, as well as animal studies to understand disease mechanisms.

  • Neuroprotection: How to Survive or Prevent the Death of Cells Affecting Vision:

    Scientists at Johns Hopkins University (JHU) and Duke University are investigating different ways to promote the survival of retinal ganglion cells (RGCs), the optic nerve cells normally damaged in glaucoma.

    JHU scientist Derek Welsbie, M.D., Ph.D., will work to understand which genes send signals that trigger the death of RGCs. Using automated microscopes and robots, he will turn off tens of thousands of genes, one by one, to see what makes the cells healthier. Zhiyong Yang, M.D., Ph.D., of JHU, along with co-principal investigator Donald J. Zack, M.D., Ph.D., will investigate whether a novel target protein can promote RGC survival, with implications for new drug treatments. Yang is the recipient of AHAF's 2012 Douglas H. Johnson award, given to the top-scoring grant applicant in glaucoma research. Shannath Merbs, M.D., Ph.D., of JHU, along with co-principal investigator Raymond A. Enke, Ph.D., will study DNA changes caused in pa
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Contact: Alice Kirkman
akirkman@ahaf.org
301-556-9349
AHAF-American Health Assistance Foundation
Source:Eurekalert

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