ARTICLE #3 FOR IMMEDIATE RELEASE
"TGF-#1 Gene Silencing for Treating Liver Fibrosis"
DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/mp9000469
Ram I. Mahato, Ph.D.
University of Tennessee Health Sciences Center
Department of Pharmaceutical Sciences
Cancer Research Building
Memphis, Tenn. 38103
ARTICLE #4 FOR IMMEDIATE RELEASE
New "microcapsules" put more medication into the bloodstream to treat disease
Scientists are reporting a potential solution to a problem that limits the human body's ability to absorb and use medications for heart disease, Type-2 diabetes, cancer and other conditions. It is a "nano-hybrid microcapsule" that enables the stomach to absorb more of these so-called "poorly-soluble" medicines. Their study is scheduled for the June 1 issue of ACS' Molecular Pharmaceutics, a bi-monthly journal.
Finding ways to improve the stomach's uptake of poorly soluble medicines has been one of the major challenges facing pharmaceutical companies. Estimates suggest, for instance, that 40 percent of potential new drugs fall into this category. In the new study, Clive Prestidge and colleagues note that one solution has been to include detergent-like substances in pills and capsules. However, that approach involves safety concerns, since the detergent can irritate the stomach lining, making it unsuitable for drugs that must be taken month after month.
The scientists describe
|Contact: Michael Woods|
American Chemical Society