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American Chemical Society's weekly PressPac -- May 27, 2009
Date:5/31/2009

ger liver inflammation, by almost 50 percent. The results suggest that gene silencing may be "an efficient and more specific approach for therapy of liver fibrosis," the report states.

ARTICLE #3 FOR IMMEDIATE RELEASE
"TGF-#1 Gene Silencing for Treating Liver Fibrosis"

DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/mp9000469

CONTACT:
Ram I. Mahato, Ph.D.
University of Tennessee Health Sciences Center
Department of Pharmaceutical Sciences
Cancer Research Building
Memphis, Tenn. 38103
Phone: 901-448-6929
Fax: 901-448-2099
Email: rmahato@utmem.edu


ARTICLE #4 FOR IMMEDIATE RELEASE

New "microcapsules" put more medication into the bloodstream to treat disease
Molecular Pharmaceutics

Scientists are reporting a potential solution to a problem that limits the human body's ability to absorb and use medications for heart disease, Type-2 diabetes, cancer and other conditions. It is a "nano-hybrid microcapsule" that enables the stomach to absorb more of these so-called "poorly-soluble" medicines. Their study is scheduled for the June 1 issue of ACS' Molecular Pharmaceutics, a bi-monthly journal.

Finding ways to improve the stomach's uptake of poorly soluble medicines has been one of the major challenges facing pharmaceutical companies. Estimates suggest, for instance, that 40 percent of potential new drugs fall into this category. In the new study, Clive Prestidge and colleagues note that one solution has been to include detergent-like substances in pills and capsules. However, that approach involves safety concerns, since the detergent can irritate the stomach lining, making it unsuitable for drugs that must be taken month after month.

The scientists describe
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Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert  

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