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American Chemical Society's weekly PressPac -- Jan. 2, 2008

Here is the latest American Chemical Society (ACS) News Service Weekly PressPac with news from ACS 36 peer-reviewed journals and Chemical & Engineering News. Please credit the individual journal or the American Chemical Society as the source for this information.

ALL CONTENT IS FOR IMMEDIATE USE EXCEPT ARTICLE #5, which is embargoed for 9 A. M., Eastern Time, Jan. 7, 2008.


Amber fossils reveal ancient France was a jungle
The Journal of Organic Chemistry

Research on a treasure trove of amber has yielded evidence that France once was covered by a dense tropical rainforest with trees similar to those found in the modern-day Amazon. The report on 55-million-year-old pieces of amber from the Oise River area in northern France is scheduled for the Jan. 4 issue of ACS Journal of Organic Chemistry, a biweekly publication.

In the new study, Akino Jossang and colleagues used laboratory instruments to analyze the fossilized tree sap in an effort to link specific samples of amber to specific kinds of trees. The amber remained intact over the ages, while the trees from which it oozed disappeared. Efforts to make such connections have been difficult because amber from different sites tended to have very similar chemical compositions. The report describes discovery of a new organic compound in amber called quesnoin, whose precursor exists only in sap produced by a tree currently growing only in Brazils Amazon rainforest.

Researchers say that amber probably seeped out of a similar tree growing in a tropical forest that covered France millions of years ago before Earths continents drifted into their current positions. The region corresponding to modern France could have been found in a geographically critical marshy zone belonging to Africa and a tropical zone 55 million years ago extending through North Africa to the Amazon, the report states. AD

ARTICLE #1 FOR IMMEDIATE RELEASE Quesnoin, a Novel Pentacyclic ent-Diterpene from 55 Million Year Old Oise Amber


Akino Jossang, Ph.D.
Musum National d'Histoire Naturelle
Paris, France
Phone: 33 01 40 79 31 28
Fax: 33 01 40 79 31 35


Benzene concentrations in beverages
Journal of Agricultural and Food Chemistry

Only nine percent of 199 beverage samples had benzene levels above the U. S. Environmental Protection Agency (EPA) limit of 5 parts per billion (ppb) for benzene in drinking water, according to a study by EPA and U. S. Food and Drug Administration (FDA) scientists. It is scheduled for the current issue of ACS Journal of Agricultural and Food Chemistry, a bi-weekly journal.

Products containing benzene above the EPA level were reformulated by the manufacturers to minimize or eliminate benzene and one product was discontinued, researchers said. Benzene levels in the reformulated products were 1.1 ppb or less. About 71 percent of beverage samples in the study contained less than 1 ppb. Based on results from the survey and actions taken by the beverage industry, FDA concluded that the levels of benzene found did not pose a safety concern for consumers.

In the study, FDAs Patricia Nyman and colleagues point out that benzene can form at ppb levels in some beverages that contain a food preservative, benzoate salt, and ascorbic acid (vitamin C). In the early 1990s, the U.S. beverage industry discovered benzene in some beverages and reformulated those products. In 2005, the substance again was found in some beverages, likely because new manufacturers were unaware of the problem, the study says. Some manufacturers also have added vitamin C to drinks in response to consumers desire for healthier products.

The study found that product formulation, shelf-life, and storage conditions were important factors affecting benzene formation. The report also describes the in-house validation of FDAs analytical method for determining benzene in beverages. JS

ARTICLE #2 FOR IMMEDIATE RELEASE Survey Results of Benzene in Soft Drinks and Other Beverages by Headspace Gas Chromatography/Mass Spectrometry


Patricia Nyman
U.S. Food and Drug Administration
College Park, Md. 20740
Phone: 301-436-1679


Toward solving the mystery of idiosyncratic drug reactions
Chemical Research in Toxicology

A mysterious and unpredictable group of side effects from modern medications called idiosyncratic drug reactions (IDRs) likely will persist as a major health care problem unless there is a dramatic increase in research funding, according to a 20-year review of research in the field scheduled for the January issue of ACS Chemical Research in Toxicology, a monthly journal.

The review, by Jack Uetrecht, defines IDRs as reactions that happen unexpectedly and with no obvious connection to the known effects of a medications ingredients or dosage. Although relatively rare, IDRs make an important contribution to the annual burden of death, illness, and increased health care costs from serious adverse drug reactions. In addition, serious IDRs that appear after a new drug has gone into wide use can force drug companies to withdraw products after R&D investments totaling hundreds of millions of dollars.

Two decades of research have produced significant progress, the report acknowledges. However, medical science still has only a superficial understanding of how and why IDRs occur and a growing recognition that the mechanisms behind IDRs may be as complicated as those involved in cancer or diabetes. The review describes a need for increased research funding, with more scientists focusing on IDRs, in order to achieve faster progress. JS

ARTICLE #3 FOR IMMEDIATE RELEASE Idiosyncratic Drug Reactions: Past, Present, and Future


Jack Uetrecht, M. D., Ph.D.
University of Toronto
Toronto, Canada M5S, 3M2
Phone: 416-978-8939
Fax: 416-978-8511


Toward preventing the warping and splitting of wood

Scientists in France and Japan report an advance toward unlocking the secrets of tension wood (TW), a step that could have practical applications in preventing costly warping and splitting of wood used in construction projects. The report is scheduled for the Jan. 14 issue of ACS Biomacromolecules, a bi-monthly journal.

In the study, Bruno Clair and colleagues point out that whereas normal wood tends to shrink a small amount when dried, TW undergoes surprisingly high shrinkage. This shrinkage makes it undesirable for use in sun decks and other construction applications. Now, researchers want a valid explanation for this phenomenon.

In the current study, Clair and colleagues collected TW and normal wood samples from a chestnut tree and exposed the samples to different drying conditions. Using nitrogen adsorption, a technique to measure the porosity of materials, they found that the TW was composed of a gel-like layer with a surface area more than 30 times higher than in normal wood. The collapse of this gel during drying likely caused TWs high shrinkage rate, the scientists say. The finding could lead to ways to reduce this shrinkage in order to make TW more usable for construction applications. MTS

ARTICLE #4 FOR IMMEDIATE RELEASE Characterization of a Gel in the Cell Wall To Elucidate the Paradoxical Shrinkage of Tension Wood


Bruno Clair, Ph.D.
Universit Montpellier 2, CNRS
Montpellier, France
Phone: 33 4 6714 4918
Fax: 33 4 6714 4792


Discovery of enzymes structure may lead to new treatments for celiac disease
Chemical & Engineering News

Researchers have discovered a new structure for a key enzyme associated with celiac disease, a finding that could lead to the design of new medications for the common digestive disorder, according to an article scheduled for the Jan. 7 issue of Chemical & Engineering News, ACS weekly newsmagazine.

Celiac disease is a condition in which the stomach cannot properly digest wheat and other gluten-containing foods. The disease afflicts an estimated 2 million people in the United States alone.

In the article, C&EN Deputy Assistant Managing Editor Stu Borman notes that the disease is believed to occur when the protein gluten interacts with an enzyme called transglutaminase 2 (TG2), triggering an autoimmune reaction that damages the small intestine and causes diarrhea, abdominal pain and other symptoms. As a result, people with the disease are urged to follow a strict gluten-free diet.

Although scientists have previously obtained the X-ray crystal structure of human TG2, they have only revealed its closed or inactive form, the article points out. Now, Chaitan Khosla and colleagues at Stanford University report the first-ever determination of the open structure of the enzyme, in which its active site is accessible to substrates. The finding that could help scientists design inhibitors of the enzyme that could serve as medications for celiac disease and other related conditions, according to the article.

ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Jan. 7, 2008 Enzyme opens for business

This story will be available on Jan. 7 at

Michael Bernstein
ACS News Service
Phone: 202-872-6042
Fax: 202-872-4370

For Wired Readers

Bytesize Science, a podcast for young listeners

The American Chemical Society (ACS) Office of Communications has launched Bytesize Science, an educational, entertaining podcast for young listeners. Bytesize Science translates cutting-edge scientific discoveries from ACS' 36 peer-reviewed journals into stories for young listeners about science, health, medicine, energy, food, and other topics. New installments of Bytesize Science are posted every Monday and available without charge. Bytesize Science is now listed as a "new and notable" podcast on iTunes. It is also being recommended by "Podcasting in Education," an organization that encourages educators to embrace podcasts as a classroom tool. The archive includes items on environmental threats to killer whales, a scientific explanation for why some people love chocolate, some unlikely new uses for compact discs, and a hairy tale about "hairy roots." The podcaster for Bytesize Science is Adam Dylewski, an ACS science writer and recent graduate of the University of Wisconsin-Madison with degrees in genetics and science communication.

Science Elements: ACS Science News Podcast

The ACS Office of Communications is podcasting PressPac contents in order to make cutting-edge scientific discoveries from ACS journals available to a broad public audience at no charge. Science Elements includes selected content from ACSs prestigious suite of 36 peer-reviewed scientific journals and Chemical & Engineering News, ACSs weekly news magazine. Those journals, published by the worlds largest scientific society, contain about 30,000 scientific reports from scientists around the world each year. The reports include discoveries in medicine, health, nutrition, energy, the environment and other fields that span sciences horizons from astronomy to zoology. Podcaster for Science Elements is Steve Showalter, Ph.D., a chemist at the U. S. Department of Energys Sandia National Laboratories in Albuquerque, N.M., and ACS member.

Journalists Resources

Highlights, resources from ACS Chocolate Workshop now online

The American Chemical Societys workshop, Cooks with Chemistry The Elements of Chocolate provided reporters with a delectable assortment of new information on the worlds favorite treat. Held Oct. 11, 2007, at the Institute of Culinary Education in New York City and sponsored by the ACS Office of Communications, the chocolate workshop featured presentations from Harold McGee and Shirley Corriher, award-winning cookbook authors, and Sara Risch, the noted food and flavor chemist. With chocolate consumption nearing an annual peak as the holidays approach, we are providing content from this event to news media unable to attend the workshop. The material includes ACS journal articles about the chemistry of chocolate; advice for cooks who run into trouble with chocolate recipes; tips on how to successfully use new chocolates in old favorite recipes; and a fascinating comparison of the health benefits and flavor components of different kinds of chocolate. For interviews with the chocolate workshop participants or other information, please contact

ACS Press Releases

General Chemistry Glossary

PressPac information is intended for your personal use in news gathering and reporting and should not be distributed to others. Anyone using advance PressPac information for stocks or securities dealing may be guilty of insider trading under the federal Securities Exchange Act of 1934.

PressPac Archive:

Science Inquiries: Michael Woods, editor

General Inquiries: Michael Bernstein


Contact: Michael Woods
American Chemical Society

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