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American Chemical Society's Weekly PressPac -- Sept. 26, 2007
Date:10/1/2007

ival in Two Murine Models of Systemic Lupus Erythematosus

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CONTACT:
Philip S. Low, Ph.D.
Purdue University
West Lafayette, IN 47907
Phone: 765-494-5273
E-mail: plow@purdue.edu

ARTICLE #2 FOR IMMEDIATE RELEASE

Subway dust may trigger lung damage
Chemical Research in Toxicology

Subway trains produce airborne dust particles that could damage the lungs of commuters, scientists in France are reporting in a study of the Paris subway system scheduled for the October issue of ACS Chemical Research in Toxicology, a monthly journal.

Sophie Lanone and colleagues point out that previous studies of the London and Stockholm subway systems also have identified such particulate matter. In their new study, the researchers collected dust samples from platform surfaces in two heavily traveled subway stations in the Paris Metro, which carried one million passengers daily. They exposed live mice and cultured mice cells to the dust over a 24-hour period.

Exposure to the subway dust triggered transient lung inflammation in the mice and increased levels of several substances produced by the immune system that might cause tissue damage. Some but not all effects occur with exposure to diesel exhaust, and other common urban air pollutants, the study said. Subway dust contained large amounts of iron particles and very low levels of endotoxin, a potentially toxic compound produced by bacteria.

To the best of our knowledge, this is the first evaluation of the biological effects of particulate matter f
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
Source:Eurekalert

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