American Chemical Society's Weekly PressPac -- Sept...(cck/2007/111/i37/pdf/jp074703f.pdf http:...)

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ARTICLE #3 FOR IMMEDIATE RELEASE

Pomegranate juice: Tart, trendy, and targeted on prostate cancer cells

Journal of Agricultural and Food Chemistry Researchers in California are reporting new evidence explaining pomegranate juices mysterious beneficial effects in fighting prostate cancer. In a study scheduled for the Sept. 19 issue of ACS Journal of Agricultural and Food Chemistry, a bi-weekly publication, Navindra Seeram and colleagues have found that the tart, trendy beverage also uses a search-and-destroy strategy to target prostate cancer cells.

In previous research, Seerams group found that pomegranate juice consumption had a beneficial effect for prostate cancer patients with rising prostate-specific antigen (PSA) levels. Such increases in PSA signal that the cancer is progressing, doubling time a key indicator of prognosis. Men whose PSA levels double in a short period are more likely to die from their cancer. Pomegranate juice increased doubling times by almost fourfold.

In the new study, they researchers discovered evidence in laboratory experiments that pomegranate works in a seek and destroy fashion. On consumption, ellagitannins (ET), antioxidants abundant in pomegranate juice, break down to metabolites known as urolithins. The researchers showed that the urolithins concentrate at high levels in prostate tissue after being given orally and by injection to mice with prostate cancer. They al
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