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American Chemical Society's Weekly PressPac -- Sept. 12, 2007

Using Portable Capillary Electrophoresis Instrumentation and Indirect Photometric Detection with a Light-Emitting Diode




Paul R. Haddad, Ph.D.
University of Tasmania
Tasmania, Australia
Phone: +61-3-6226-2179


New way to watch the lipid flip flippases, flopases, and scramblases
Bioconjugate Chemistry

The lipid flip may sound like a rock and roll dance craze from the 1960s. However, it actually is a key biochemical process in which fatty materials termed lipids move into cells movements that are pointing toward improvements in gene therapy, new medications for preventing the complications of Alzheimers disease, and other health boons.

In an article scheduled for the Sept. 19 issue of ACS Bioconjugate Chemistry, a bi-monthly journal, Vladimir Sidorov and colleagues report development of a new non-invasive method for monitoring the activity of lipid-flipping enzymes. Colorfully named flippases, flopases, and scramblases, these enzymes control the process in which lipid molecules literally summersault from the outer layer of a cell membrane to the inner layer where they can move into the cell itself. The actions of those enzymes can influence blood clotting, whether a cell lives or programs itself for death, and other processes.

In their study, the researchers describe drawbacks in existing methods for monitoring lipid. Their new laboratory method overcomes those

Contact: Michael Woods
American Chemical Society

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