Navigation Links
American Chemical Society's Weekly PressPac -- Nov. 14, 2007
Date:11/19/2007

Scientists in Indiana and Michigan have developed a better way of mining a vast computerized database for chemical nuggets that could become tomorrows cancer medications. The new data mining method pinpoints chemical structures with drug-like activity. It could speed the identification and development of new, more effective drugs against breast, prostate, lung and other cancers, according to a report scheduled for the Nov./Dec. issue of ACS Journal of Chemical Information and Modeling, a bi-monthly publication.

Computers have become a mainstay in the drug discovery process and have led to the identification of dozens of promising anticancer drugs. However, as the amount and complexity of information in a chemical

In the new report, David J. Wild and colleagues analyzed data from the National Cancer Institute Developmental Therapeutics Program, a database of 40,000 compounds that have been tested against 60 tumor cell lines. The researchers identified a set of common structural features that can be used to more accurately predict which compounds are most active against cancer cells. In a series of experiments, they showed that applying these new criteria significantly increased the accuracy rate of identifying drug-like molecules in comparison to standard screening methods.

ARTICLE #4 FOR IMMEDIATE RELEASE

Chemical Data Mining of the NCI Human Tumor Cell Line Database

DOWNLOAD PDF http://pubs.acs.org/cgi-bin/sample.cgi/jcisd8/asap/pdf/ci700141x.pdf
DOWNLOAD HTML http://pubs.acs.org/cgi-bin/sample.cgi/jcisd8/asap/html/ci700141x.html

CONTACT:

David J. Wild, Ph.D.
Indiana Universi
'/>"/>

Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society  
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10

Related biology news :

1. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
2. Understanding hypertension in African Americans proves elusive
3. Tips from the Journals of the American Society for Microbiology
4. American Chemical Societys Weekly PressPac -- Aug. 15, 2007
5. American College of Medical Genetics responds to new FDA labeling decision for warfarin
6. American Chemical Societys Weekly Press Pac
7. Highlights from the September 2007 Journal of the American Dietetic Association
8. American Chemical Societys Weekly Presspac -- Aug. 29, 2007
9. Report: African, Asian, Latin American farm animals face extinction
10. American Chemical Society calls green chemistry bill a smart step
11. Challenges remain in reintroducing American chestnut
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
American Chemical Society's Weekly PressPac -- Nov. 14, 2007
(Date:10/1/2014)... Finland , October 1, 2014 ... through in the life science field  ... technologies come and go over the years. Some ... standard. Photon upconversion is a novel detection technology ... recent years. Now, finally, this technology is becoming ...
(Date:9/30/2014)... Millions of tourists visit the Mediterranean each year, ... currently underway on Earth. Almost 1,000 alien species, ... from other seas through human activities. In the ... a multinational team of researchers analyzed data from ... Commission to show how the introduction of alien ...
(Date:9/30/2014)... California, San Diego, have completed the first comprehensive numerical ... uses the pixels in an image as data points ... , The researchers, led by J.S. Chen, the William ... of Engineering at UC San Diego, presented their findings ... conference in Pittsburgh this month. Chen also gave a ...
Breaking Biology News(10 mins):First-of-a-kind Solution for Utilizing Photon Upconversion 2Biodiversity in the Mediterranean is threatened by alien species 2First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2
... study shows that human milk oligosaccharides, or HMO, produce short-chain ... infant gut. Not only that, the bacterial composition adjusts as ... though HMO are a major component of human milk, present ... the infant are not well understood. Furthermore, they,re virtually absent ...
... JOLLA, CA ---- Scientists at the Salk Institute for ... of plant proteins that play a role in the ... human nutrition, biorenewable chemicals and biofuels. Scoring a ... related proteins in thale cress plants ( Arabidopsis thaliana ...
... thanks to a paper-thin generator embedded in the sole ... little closer to reality. Scientists from the U.S. Department ... developed a way to generate power using harmless viruses ... tested their approach by creating a generator that produces ...
Cached Biology News:Study sheds new light on importance of human breast milk ingredient 2Discovery of plant proteins may boost agricultural yields and biofuel production 2Discovery of plant proteins may boost agricultural yields and biofuel production 3Berkeley Lab scientists generate electricity from viruses 2Berkeley Lab scientists generate electricity from viruses 3
(Date:10/1/2014)... 30, 2014 In response to ... to address sales, training and consumer engagement challenges, ... innovative mobile applications to turn their clients’ visions ... latest customized mobile app creations, are now featured ... In partnership with Toyota, StudioPMG created a robust ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 The U.S. ... to Southern Illinois University Edwardsville as part of the ... initiative. The funding is co-administered by the Department of ... Biden, Secretary of Labor Thomas E. Perez and Secretary ... million in job-driven training grants to nearly 270 colleges ...
(Date:9/30/2014)... German . ... have demonstrated a new kind of building block for ... chips could be based on three-dimensional arrangements of nanometer-scale ... of the semiconductor industry CMOS fabrication of silicon ... collaborators at the University of Notre Dame are exploring ...
(Date:9/30/2014)... Sept. 30, 2014 Nematicide is a ... Nematodes are microscopic parasitic roundworms, found in massive ... other plants and animals. Nematicides have tended to ... properties promoting migration through the soil. A single ... plant-parasitic nematodes. With more than 10,000 species classified, ...
Breaking Biology Technology:Digital Agency Studio PMG Launches New Case Studies on Website 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2
... conference at Grainger Hall. Madison, Wis. ... Wisconsin, according to the Coalition for Capital Growth and Research, ... Hall. , ,We believe [venture capital] is a worthwhile agenda ... partner at Venture Investors and the conferences founder. ...
... a look at how the large cap Midwest life science companies ... stock market. The results looked very positive for at least 75 ... market growth. , ,On the negative side, some of the poor ... our largest Big Pharma companies (namely Abbott Labs and Eli Lilly). ...
... I never cease to be amazed by the games that ... to goose up revenues and shore up profits. Most of ... Lately, things have gotten ridiculous enough to make one yearn ... calls. , ,And Im not talking about the nuisance of ...
Cached Biology Technology:Wisconsin investors seek regional partners and informed legislature 2Wisconsin investors seek regional partners and informed legislature 3Midwest small-cap life sciences turn in mixed third-quarter results 2Show customers leadership, not gamesmanship 2Show customers leadership, not gamesmanship 3
... The FastPlax Antibody is used to ... on the surface of infected cells as ... the basis of the FastPlax Titer Kit, ... just 25-48 hours. The FastPlax ...
Anti-Mouse Ly 6C.2 , Ascites (Clone 5075-3.6) (mouse IgG2b)...
b-Catenin (pSer675), phospho-specific...
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
Biology Products: