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American Chemical Society's Weekly PressPac -- May 13, 2009
Date:5/17/2009

issue of ACS' Journal of Proteome Research, a monthly publication. About 18 million people in the United States have Type 2 diabetes, and the disease is spreading with the epidemic of obesity.

David Springer and colleagues point out in the new study that thousands of patients receive potentially lifesaving transfusions of platelets each year to treat bleeding from trauma and for a wide range of medical conditions. Scientists have known that abnormal platelets in the blood of diabetics may predispose these individuals to heart disease. It led to concern that platelets from these individuals stored for transfusion may be less effective and even unsafe. However, scientists know little about how diabetic platelets differ from those of healthy people.

The new study identified 122 proteins that differed in the platelets of individuals with diabetes compared to the platelets of non-diabetics. They also found that freshly collected platelets from diabetics show almost as many abnormal changes (more than 100) in protein content as healthy donor platelets stored for up to 5 days. These findings could lead to new tests for detecting and monitoring abnormal platelets to improve the outcome of blood transfusions from both diabetic and healthy individuals, the researchers say.

ARTICLE #4 FOR IMMEDIATE RELEASE
"Platelet Proteome Changes Associated with Diabetes and during Platelet Storage for Transfusion"

DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/pr800885j

CONTACT:
David Springer, Ph.D.
Biological Sciences Division
Pacific Northwest national Laboratory
Richland, Wash. 99352
Phone: 509-372-6762
Fax: 509-372-6544
Email: david.springer@pnl.gov


ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, May 18,
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Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert  

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