American Chemical Society's Weekly PressPac -- Ju...(e genes to be active and churn out prote...)

Date:6/8/2009

e genes to be active and churn out proteins so-called transcriptional activators. That's because they control a key process known as transcription, in which instructions coded in genes produce proteins. Malfunctions in these activators could lead to altered transcription patterns that lead to disease. For example, variations in the tumor suppressor gene p53 are found in more than half of all human cancers.

Mapp describes discovery of a group of molecules that could be used to help scientists better understand transcription. Known as activator artificial transcriptional activation domains, these small molecules mimic natural activators and could provide insights on how mistakes in gene regulation result in various diseases. "Evidence suggests that these small molecules mimic the function and mechanism of their natural counterparts and present a framework for the broader development of small molecule transcriptional switches," Mapp states.

ARTICLE #4 FOR IMMEDIATE RELEASE
"Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors"

DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/cb900028j

CONTACT:
Anna K. Mapp, Ph.D.
University of Michigan
Ann Arbor, Mich.
Phone: (734) 615-6862
Fax: (734) 647-4865
Email: amapp@umich.edu

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ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, June 8, 2009

Growing demand for certain metals creates new push for sustainability
Chemical & Engineering News

Growing demand for certain metals used in automotive catalytic converters, computers, and other widely-used products combined with a limited supply is fostering a quest for ways to apply the principles of sustainability to humanity's use of metals. That's the topic of
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Contact: Michael Woods m_woods@acs.org 202-872-6293 American Chemical Society Source:Eurekalert

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