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American Chemical Society's Weekly PressPac -- Aug. 27, 2008
Date:9/1/2008

E RELEASE
"Noninvasive Metabolic Profiling Using Microfluidics for Analysis of Single Preimplantation Embryos"

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http://dx.doi.org/10.1021/ac8010473

CONTACT:
Todd Thorsen, Ph.D.
Massachusetts Institute of Technology
Cambridge, Massachusetts 02139
Phone: 617-253-9379
Fax: 617-258-8559
Email: thorsen@mit.edu


ARTICLE #2 FOR IMMEDIATE RELEASE

New evidence on folic acid in the diet and colon cancer
Journal of Proteome Research

Researchers in the United Kingdom and Texas are reporting a new, more detailed explanation for the link between low folate intake and an increased risk for colon cancer, the second leading cause of cancer death in the United States. Their study, which reinforces the importance of folate in a healthy diet, is scheduled for the current (August) issue of ACS' monthly Journal of Proteome Research.

Susan Duthie and colleagues note that researchers have known for years that a deficiency of folate, one of the B vitamins commonly called folic acid, increases the risk of birth defects. As a result, manufacturers enrich some foods with folate. Scientists also have found that low folate in the diet increases the risk of developing colon cancer in adults. However, scientists lack an adequate explanation of how folate depletion affects the genes, proteins, and cells involved in cancer.

In this new research, scientists grew human colon cells in folate-depleted and folate-enriched tissue culture. They found that folate depletion caused increased DNA damage and a cascade of other biological changes linked to an increased cancer risk.

ARTICLE #2 FOR IMMEDIATE RELEASE
"The Response of Human Colonocytes to Folate Deficiency in Vitro: Functional and Proteomic Analyses"

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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
Source:Eurekalert  

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