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American Chemical Society's Weekly PressPac -- Aug. 13, 2008
Date:8/19/2008

, organ-transplant rejection, and infection, the researcher says. These findings represent the first controlled human studies of this type of drug-lowering interaction, he says.

"Recently, we discovered that grapefruit and these other fruit juices substantially decrease the oral absorption of certain drugs undergoing intestinal uptake transport," says study leader David G. Bailey. "The concern is loss of benefit of medications essential for the treatment of serious medical conditions."

Bailey and colleagues announced almost 20 years ago the unexpected finding that grapefruit juice can dramatically boost the body's levels of the high-blood-pressure drug felodipine, causing potentially dangerous effects from excessive drug concentrations in the blood. Since then, other researchers have identified nearly 50 medications that carry the risk of grapefruit-induced drug-overdose interactions. As a result of the so-called "Grapefruit Juice Effect," some prescription drugs now carry warning labels against taking grapefruit juice or fresh grapefruit during drug consumption. MTS

ARTICLE #5 EMBARGOED FOR RELEASE: Tuesday, Aug. 19, 9:30 a.m., Eastern Time

For full-text of press release:
http://oasys.acs.org/output/process_last_run/acs/236nm/-acs-236nm-newsservice-webprogram-cgi.html

CONTACT:
David G. Bailey, Ph.D.
University of Western Ontario
London, Ontario N6A 4G5
Canada
Phone: 519-685-8500 ext 35234
Email: david.bailey@lhsc.on.ca


ARTICLE #6

Key advance toward "micro-spacecraft"

EMBARGOED FOR RELEASE: Tuesday, Aug. 19, 10:30 a.m., Eastern Time

Fleets of inexpensive, pint-sized spacecraft are one giant leap closer to lift off, researchers report. Scientists describe a new, razor thin te
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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
Source:Eurekalert  

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