American Chemical Society's Weekly PressPac -- Apri...(brPittsburgh Pa. 15213 Phone: (412) 268-...)

New insights on link between early consumption of cows milk and Type-1 diabetes
Journal of Proteome Research

Researchers in Maine report a new explanation for the mysterious link between consumption of cows milk protein in infant formula early in life and an increased risk of later developing Type-1 diabetes. A protein in cows milk that triggers an unusual immune response appears to be the main culprit, they say. The study is scheduled for the June 6 issue of ACS monthly Journal of Proteome Research.

In the new study, Marcia F. Goldfarb points out that several studies have reported a possible link between the early introduction of cows milk protein into an infants diet and subsequent development of the disease. In Type-1 diabetes, the immune system erroneously appears to attack and destroy insulin-producing cells in the pancreas. It usually begins in childhood, requires insulin injections, and afflicts about 800,000 people in the U.S. alone. Scientists do not understand the link between cows milk and diabetes. They know, however, that beta-lactoglobulin, a protein present in cows milk but not found in human breast-milk, is structurally similar to the human protein glycodelin, which controls the production of T-cells. T-cells help guard the body against infection.

Goldfarb describes research on patients with Type-1 diabetes, which suggests that an infants immature immune system may inadvertently destroy glycodelin in an effort to destroy the similar cows milk protein, which the system recognizes as foreign. This could result in the overproduction of T-cells, which can attack the insulin-producing cells of the pancreas and trigger diabetes, she says. MTS

ARTICLE #2 FOR IMMEDIATE RELEASE
Relation of Time of Introduct
'/>"/>