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American Chemical Society's Weekly PressPac -- April 23, 2008
Date:4/28/2008

Here is the latest American Chemical Society (ACS) News Service Weekly PressPac with news from ACS 36 peer-reviewed journals and Chemical & Engineering News. Please credit the individual journal or the American Chemical Society as the source for this information.

ALL CONTENT IS FOR IMMEDIATE USE EXCEPT ARTICLE #5, which is embargoed for 9 a. m., Eastern Time, April 28, 2008.

ARTICLE #1 FOR IMMEDIATE RELEASE

Study calls for action on heart risks from certain anti-cancer drugs
Chemical Research in Toxicology

Heart damage from certain anti-cancer drugs no longer should be regarded as a rare or relatively unimportant complication, scientists in Italy have concluded in a new overview of research on the cardiotoxicity of anti-cancer drugs. Their review, scheduled for the May 19 issue of ACS monthly journal, Chemical Research in Toxicology, recommends that drug regulatory agencies, physicians, and toxicologists join in a focused research effort to combat the problem.

In the new study, Giorgio Minotti, Pierantonio Menna, and Emanuela Salvatorelli point out that the risk of cardiotoxicity may be higher than previously believed, especially in older patients and those with high blood pressure, coronary artery disease, and other risk factors. Studies of long-term survivors of childhood and adult cancer more than 10 million people in the United States alone also suggest an increased risk of symptomatic cardiac events.

Their review found that newer, targeted drugs can damage the heart, particularly when combined with old-generation chemotherapeutics. Toxicologists and regulatory agencies and clinicians should therefore join in collaborative efforts that improve early identification of cardiotoxicity and minimize the risks of cardiac events in patients, the article notes. MTS

ARTICLE #1 FOR IMMEDIATE RELEASE Cardiotoxicity of Antitumor Drugs

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Contact: Michael Woods
m_woods@acs.org
202-872-4400
American Chemical Society
Source:Eurekalert  

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