ARTICLE #1 EMBARGOED FOR: Wednesday, Aug. 22, 9:00 a.m., Eastern Time
Stig Friberg, Ph.D.
University of Virginia
Charlottesville, Va. 22911
ARTICLE #2 EMBARGOED FOR: Wednesday, Aug. 22, 10:45 a.m., Eastern Time
Some forms of good cholesterol can be bad for the heart
Good cholesterol, renowned for its ability to protect against heart disease, can undergo detrimental changes in protein composition that make it bad for the heart, according to a new laboratory study by researchers in Seattle, Wash.
Scientists long have suspected that there may be dysfunctional forms of so-called good cholesterol, also called high density lipoprotein (HDL) cholesterol, that can lose their heart-protective effect. But the exact chemical composition of HDL, both good forms and bad, has remained largely unknown, researchers say.
In what is believed to be the most detailed analysis to date of the protein composition of HDL, Jay Heinecke and colleagues uncovered surprising new information about HDL, including previously unrecognized proteins that appear to play an important role in maintaining heart health. Their findings could one day lead to new, more accurate lab tests for heart disease as well as new, potentially life-saving treatments for the disease, which is the number one killer in the United States and other developed countries.
Targeting HDL could represent a new horizon in heart disease diagnosis and treatment, Heinecke said. But simply boosting HDL levels may not be enough to prevent heart disease. You might have to target the right proteins in HDL.
ARTICLE #2 EMBARGOED FOR: Wednesday, Aug. 22, 10:45 a.m., Eastern
|Contact: Michael Woods|
American Chemical Society