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American Chemical Society weekly presspac -- June 10, 2009
Date:6/15/2009

th because they would be destroyed by stomach acid without being absorbed into the bloodstream. One promising approach is to use live bacteria, which can survive those harsh conditions and pass easily from the GI tract into the blood.

The scientists describe development of a new strain of Listeria monocytogenes, bacteria that normally cause food poisoning, but which have been genetically engineered to be harmless. Instead of causing disease, the new microbes can be loaded with medicine or vaccine, and deliver that beneficial cargo by "infecting" cells. After entering cells, the bacteria burst and die, leading to Pouton's term "suicidal strain" for the microbes. The researchers demonstrated that engineered bacteria containing a test protein could successfully penetrate a group of intestinal cells grown in the lab and deliver the protein inside the cells while leaving the cells unharmed. The findings suggest that the approach could potentially work in humans, the researchers say.

ARTICLE #4 FOR IMMEDIATE RELEASE
"A Stably engineered, Suicidal Strain of Listeria monocytogenes Delivers Protein and/or DNA to Fully Differentiated Intestinal Epithelial Monolayers"

DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/mp800153u

CONTACT:
Colin Pouton, Ph.D.
Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences
Monash University (Parkville Campus)
Melbourne, Australia
Phone: 61-3-99039562
Fax: 61-3-99039638
Email: colin.pouton@pharm.monash.edu.au

ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, June 15, 2009

Solar energy technology gets more visually-appealing makeover
Chemical & Engineering News

Those unsightly rooftop solar panels hailed as energy save
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Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society
Source:Eurekalert  

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