Navigation Links
Alzheimer's starts earlier for heavy drinkers, smokers

CHICAGO Heavy drinkers and heavy smokers develop Alzheimers disease years earlier than people with Alzheimers who do not drink or smoke heavily, according to research that will be presented at the American Academy of Neurology 60th Anniversary Annual Meeting in Chicago, April 1219, 2008.

These results are significant because its possible that if we can reduce or eliminate heavy smoking and drinking, we could substantially delay the onset of Alzheimers disease for people and reduce the number of people who have Alzheimers at any point in time, said study author Ranjan Duara, MD, of the Wien Center for Alzheimers Disease at Mount Sinai Medical Center in Miami Beach, FL, and Fellow of the American Academy of Neurology.

It has been projected that a delay in the onset of the disease by five years would lead to a nearly 50-percent reduction in the total number of Alzheimers cases, said Duara. In this study, we found that the combination of heavy drinking and heavy smoking reduced the age of onset of Alzheimers disease by six to seven years, making these two factors among the most important preventable risk factors for Alzheimers disease.

The study looked at 938 people age 60 and older who were diagnosed with possible or probable Alzheimers disease. The researchers gathered information from family members on drinking and smoking history and determined whether the participants had the 4 gene variant of the APOE gene, which increases the risk of Alzheimers disease. People with the 4 variant also develop Alzheimers at an earlier age than those who do not have the gene variant.

Seven percent of the study participants had a history of heavy drinking, which was defined as more than two drinks per day. Twenty percent had a history of heavy smoking, which was defined as smoking one pack of cigarettes or more per day. And 27 percent had the APOE 4 variant.

Researchers found that people who were heavy drinkers developed Alzheimers 4.8 years earlier than those who were not heavy drinkers. Heavy smokers developed the disease 2.3 years sooner than people who were not heavy smokers. People with APOE 4 developed the disease three years sooner than those without the gene variant.

Adding the risk factors together led to earlier onset of the disease. People who had all three risk factors developed the disease 8.5 years earlier than those with none of the risk factors. The 17 people in the study with all three risk factors developed Alzheimers at an average age of 68.5 years; the 374 people with none of the three risk factors developed the disease at an average age of 77 years.


Contact: Rachel Seroka
American Academy of Neurology

Related biology news :

1. Paradigm shift in Alzheimerss research: new treatments
2. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
3. Researchers detect hint of oxygen 50 to 100 million years earlier than first believed
4. Earlier bites by uninfected mosquitoes boost West Nile deaths in lab mice
5. Texas A&M scientists say early Americans arrived earlier
6. Heavy rainfall on the increase
7. Heavy metals in the Peak District -- evidence from bugs in blanket bogs
8. Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake
Post Your Comments:
(Date:11/20/2015)... Connecticut , November 20, 2015 ... authentication company focused on the growing mobile commerce market ... CEO, Gino Pereira , was recently interviewed on ... interview will air on this weekend on Bloomberg ... Latin America . --> NXTD ) ("NXT-ID" ...
(Date:11/19/2015)... MOUNTAIN VIEW, Calif. , Nov. 19, 2015 /PRNewswire/ ... authentication market, Frost & Sullivan recognizes BIO-key with the ... Strategy Leadership. Each year, Frost & Sullivan presents this ... comprehensive product line catering to the needs of the ... which the product line meets and expands on customer ...
(Date:11/19/2015)... 2015  Although some 350 companies are actively involved ... few companies, according to Kalorama Information. These include Roche Diagnostics, ... market share of the 6.1 billion-dollar molecular testing market, ... for Molecular Diagnostic s .    ... controlled by one company and only a handful of ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Malaysia , Nov. 24, 2015  Asia-Pacific ... contract research organisation (CRO) market. The trend of ... in lower margins but higher volume share for ... capacity and scale, however, margins in the CRO ... Organisation (CRO) Market ( ), finds ...
(Date:11/24/2015)... N.J. (PRWEB) , ... November 24, 2015 , ... The ... the recipient of the 2016 USGA Green Section Award. Presented annually since 1961, the ... through his or her work with turfgrass. , Clarke, of Iselin, N.J., ...
(Date:11/24/2015)... SUNNYVALE, Calif. , Nov. 24, 2015 ... executives will be speaking at the following conference, and ... New York, NY      Tuesday, December 1, ... New York, NY      Tuesday, December 1, ...      Piper Jaffray Healthcare Conference, New York, NY ...
(Date:11/24/2015)... Therapeutics, Inc. (NASDAQ: HALO ) will be presenting at the ... on Wednesday, December 2 at 9:30 a.m. ET/6:30 a.m. PT . ... a corporate overview. th Annual Oppenheimer Healthcare Conference ... a.m. PT . Jim Mazzola , vice president of ... --> th Annual Oppenheimer Healthcare Conference in ...
Breaking Biology Technology: